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PubMed Journals Articles About "Imaging Tumorous Methylglyoxal Activatable Near Infrared Fluorescent Probe" RSS

14:32 EST 18th January 2020 | BioPortfolio

Imaging Tumorous Methylglyoxal Activatable Near Infrared Fluorescent Probe PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Imaging Tumorous Methylglyoxal Activatable Near Infrared Fluorescent Probe articles that have been published worldwide.

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Showing "Imaging Tumorous Methylglyoxal Activatable Near Infrared Fluorescent Probe" PubMed Articles 1–25 of 11,000+

Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity.

The accurate detection of tumorous methylglyoxal (MGO) and its detoxifier glyoxalase 1 (GLO1) in living systems is critical for understanding their roles in tumor initiation and progression. To date, the in situ fluorescence detection of endogenous MGO and GLO1 in tumor has not been reported. Herein we developed a near-infrared (NIR) fluorescent probe to specifically detect tumorous MGO. Compared with previously reported MGO fluorescent probes, exhibits several distinct advantages, including NIR emission,...


Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid.

Photoacoustic (PA) imaging is a novel imaging modality that combines the high contrast of optical imaging and the deep tissue penetration of ultrasound. PA imaging contrast agents targeting various biological phenomena have been reported, but the development of activatable PA probes, which show a PA signal only in the presence of target molecules, remains challenging in spite of their potential usefulness for real-time PA imaging of specific biomolecules in vivo. To establish a simple design strategy for ac...

A seminaphthorhodafluor-based near-infrared fluorescent probe for hydrazine and its bioimaging in living systems.

Hydrazine (NH) has been classified as a potential carcinogen with its high toxicity, which can be readily absorbed through the skin or via breathing directly. Although some fluorescent probes have been developed for imaging of NH, very little can be used for imaging of NH in vivo because of its short emission wavelength. In this study, a new colorimetric and near-infrared (NIR) fluorescent probe CF-1 based on a seminaphthorhodafluor dye was successfully designed and used for hydrazine determination. Upon re...


Development of a water-soluble near-infrared fluorescent probe for endogenous cysteine imaging.

We designed and synthesized a water-soluble near-infrared (NIR) fluorescent probe with the recognition unit of the cyanine-like structure and acrylate group. Through an aromatic ring nucleophilic substitution reaction based on sulfhydryl moiety, an off-on fluorescence response toward cysteine (Cys) was realized. The probe exhibited excellent spectral performance with an emission wavelength of 720 nm and a detection limit of 0.20 μM. The spectral properties, selectivity and anti-interference performance...

Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging.

Mitochondria are essential organelles in eukaryotic cells and act as the energy powerhouse and biosynthetic compartment. Fluorescent dyes are widely used powerful molecular tools for analytical sensing and optical imaging. Low photostability, short excitation and emission wavelengths, and aggregation-induced quenching effects restrict the application of traditional commercial mitochondrial fluorescent probes for bioimaging. In this study, using rhodamine as the acceptor and phenothiazine as the donor, we sy...

An Unsymmetrical Squaraine-based Activatable Probe for Imaging Lymphatic Metastasis through Responding to Tumor Hypoxia by MSOT and Aggregation-enhanced Fluorescent Imaging.

Optoacoustic imaging exhibits great potential for preclinical research and clinical practice, and designing robust activatable optoacoustic probes for specific diseases is beneficial for its further development. Herein, an activatable probe has been developed for tumor hypoxia imaging. For this probe, indole and quinoline were linked on each side of oxocyclobutenolate core to form an unsymmetrical squaraine. Triarylamine group was incorporated to afford the aggregation enhanced emission (AEE) property. In a...

An isophorone-fused near-infrared fluorescent probe with a large Stokes shift for imaging endogenous nitroxyl in living cells and zebrafish.

Nitroxyl (HNO) plays an important role in multiple physiological and pathological processes, but the detailed generation mechanism of the endogenous HNO still remained to explore and perfect further. There is an urgent need to develop an excellent fluorescent probe for selective recognition and sensitive detection of HNO in biological systems. Near-infrared (NIR) fluorescent probes with a large Stokes shift are an ideal tool for bioimaging applications. Here, we have developed a NIR fluorescent probe with a...

A near-infrared fluorescent probe based on boric acid hydrolysis for hydrogen peroxide detection and imaging in HeLa cells.

Using the characteristics of hydrogen peroxide that are able to cleave phenyl-boric acid selectively and efficiently, we here report a dicyanoisophorone-boric acid (DCP-BA)-based near-infrared (NIR) fluorescent probe for detection of hydrogen peroxide. This probe shows a rapid, highly selective, and sensitive detection process for hydrogen peroxide with a significant NIR fluorescent turn-on response that has been successfully applied to detect exogenous hydrogen peroxide in HeLa cells.

A near-infrared fluorescent probe for the ratiometric detection and living cell imaging of β-galactosidase.

β-Galactosidase (β-gal) has captured the attention of biologists, chemists, and medical researchers as an important biomarker for cell senescence and primary ovarian cancer. Therefore, many fluorescent probes with visible light emission have been developed for the detection and imaging of β-gal in living cells. However, near-infrared (NIR) ratiometric probes are more suitable for bioimaging because near-infrared light can effectively avoid the interference of autofluorescence and the ratiometric approach...

A unique off-on near-infrared QCy7-derived probe for selective detection and imaging of hydrogen sulfide in cells and in vivo.

Hydrogen sulfide (HS) has been found to be an important biological regulator that plays important roles in many physiological and pathological processes. Near-infrared (NIR) fluorescent probes capable of selectively detecting HS in vivo will be useful tools to understand its mechanisms in biological processes. Herein, we reported an easily synthesized and stimuli-responsive NIR fluorescent probe (QCy7-HS) for selective evaluation of endogenous HS in the living cells and mice. In response to cellular HS sti...

An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition.

Hypoxia is a key hallmark of solid tumors and tumor hypoxia usually contributes to cancer progression, therapeutic resistance and poor outcome. Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcome. : Tumor hypoxia can cleave the azo linker and release a NIR fluorophore (NR-NH) and release the active drug as well. NR-NH shows a strong absorption band at around 680 nm and a strong fluore...

A novel near-infrared fluorescent probe for the dynamic monitoring of the concentration of glutathione in living cells.

In this study, a water-soluble, near-infrared fluorescent probe (EQR-S) was designed for the measurement of the glutathione (GSH) concentration. Responses of different interfering substances to the developed probe were investigated, and the luminescence mechanism was examined by theoretical calculations. Results revealed that EQR-S can be applied for the rapid, sensitive determination of the GSH concentration with a detection limit of 69 nM. Based on the above advantages, EQR-S was successfully applied to...

A novel near-infrared fluorescent probe for detection of hypobromous acid and its bioimaging applications.

Hypobromous acid (HOBr) is an important reactive oxygen species and has been recently found to be associated with a variety of diseases. However, owing to a lack of effective analytical tools, there is still limited understanding of its roles in living systems. Here, we present a new type of near-infrared fluorescent probe DCSN for HOBr detection. The designed probe exhibits high sensitivity with a low detection limit, excellent selectivity over other interfering species and low cytotoxicity. More interesti...

Triphenylamine Schiff base as a lipid droplet-targeted fluorescent probe using Si-O-Si as a bridge for the detection of Cr applied in bio-imaging.

Lipid droplets are known to play an important role in many cellular activities, as revealed by recent studies. Additionally, hexavalent chromium is considered extremely toxic because it readily passes through cellular membranes and easily accumulates in living cells. In this study, a novel lipid droplet-targeted fluorescent probe (Si-LDS) for recognition of Cr6+ in living cells was designed and synthesized using triphenylamine derivatives and organosiloxane. Si-LDS detected Cr6+ with high selectivity and se...

Light-driven visualization of endogenous cysteine, homocysteine, and glutathione using a near-infrared fluorescent probe.

Herein, we presented a hydrosoluble triple-site and triple-excitation alternative NIR fluorescent probe for visualization of endogenous biothiols in phosphate-buffered saline (pH 7.4, 10 mM). Upon irradiation using different excitation light, probe 1 exhibited different fluorescence responses upon the addition of Cys, Hcy, and GSH: λex = 419 nm, λem = 498 nm; λex = 518 nm, λem = 573, 616, 727, and 783 nm; λex = 555 nm, λem = 612 and 727 nm, respectively. Furthermore, 1 was favourably applied for bioim...

Multilayered Activatable Nanoprobe for Ultra-Bright Tumor Imaging.

The development of tumor targeted probes with strong signal and high contrast is always challenging in cancer imaging. Here, a unique multilayered activatable nanoprobe (MAN) is prepared to fulfill this long-standing goal. MAN adopts a versatile layer-by-layer fabrication technique that sequentially assembles multifunctional polyelectrolytes onto nanoparticles via charge-charge interaction. Unlike the common one-probe-one-fluorochrome construct, MAN offers a dramatic fluorescence enhancement by transporting...

A near-infrared ratiometric fluorescence probe base on spiropyran derivative for pH and its application in living cells.

The intracellular pH has a significant effect on several essential biological processes such as material transfer, enzymatic action, cell apoptosis et al. Thus, it is necessary to monitor pH fluctuation in living cells. Here, we designed a near-infrared ratiometric fluorescence probe for pH detection. The spectroscopic responses of probe to pH variations were investigated in CHOH/PBS (v/v, 1:1) mixed solution at different pH values. The experimental results showed that the probe is sensitive to acidity, and...

Modulating near-infrared persistent luminescence of core-shell nanoplatform for imaging of glutathione in tumor mouse model.

Developing near-infrared (NIR) persistent luminescence (PersL) bioprobes has attracted increasing attention due to their ultra-low autofluorescence and deep tissue penetration. Accurate imaging of glutathione (GSH) in vivo is of great significance to provide a real-time visualization of pathologies. Herein, manipulating metal ions as the switch of NIR afterglow was demonstrated to construct NIR PersL nanoprobes for the first time, which was highly efficient and much simpler than the luminescence resonance e...

A novel colorimetric-fluorescent probe for Al and the resultant complex for F and its applications in cell imaging.

A novel quinoline-based Schiff-base probe QL had been synthesized, which could sequentially monitor Al and F in MeOH-HO solution (v/v = 8/1, 0.01 M, HEPES buffer, pH = 7.3). The probe QL expressed a high selective and sensitive "OFF-ON-OFF" fluorescent response for Al and F (excitation at 460 nm and emission at 530 nm) accompanying visible color changed, which was ascribed to intramolecular charge transfer (ICT) process and chelation-enhanced fluorescence (CHEF) mechanism. The binding stoichio...

An AIE active pyrene based fluorescent probe for selective sensing Hg and imaging in live cells.

A novel fluorescence probe pyrene based derivatives (1) with aggregation induced emission (AIE) properties was synthesized by an easy procedure. The probe 1 was characterized by UV-vis, Fluorescent, NMR, MS, SEM etc. It displayed high sensitivity and selectivity to Hg compared with other metal ions in HO/DMF solvent and the detection limit was 4.2 × 10 M. Upon addition of Hg, the 1 - Hg compound was formed with the formation of 2:1. More importantly, the probe exhibited very low cytotoxicity and ...

Two-photon fluorescent Zn probe for ratiometric imaging and biosensing of Zn in living cells and larval zebrafish.

As an essential transition-metal ion in organism, zinc ion (Zn) plays a significant role in cellular metabolism, apoptosis and neurotransmission. Herein, we reported a new intramolecular charge transfer-based two-photon probe, (E)-1-(6-(4-(2-(2-(2-methoxyethoxy)ethoxy)eth-oxy)-3,5-dimethylstyryl)quinolin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine (TEO-MPVQ), for ratiometric imaging and biosensing of Zn in living cells and larval zebrafish. The maximum two-photon absorption cross-section values (δ) of the...

Development of a fast-responsive and turn on fluorescent probe with large Stokes shift for specific detection of cysteine in vivo.

Cysteine has a great effect on the physiological and pathological processes, which could bring out various diseases such as skin lesions, edema, hair depigmentation, Alzheimer's, Parkinson's, and liver damage due to the abnormal concentrations of cysteine. Therefore, it is of great impoatance to develop a method for imaging Cys. Herein, a novel fluorescent probe was developed for imaging Cys in vivo specially. This turn-on probe exhibited favorable advantages including large Stokes shift (90 nm), fast res...

Tissue-Imaging of Glutathione-Specifical Naphthalimide-Cyanine Dye with Two-Photon and Near-Infrared Manners.

Molecular probes suitable for different fluorescence imaging technologies can meet the requirements of different scientific researches in biological applications. In this work, a naphthalimide-cyanine based sulfonamide was used to specifically visualize the glutathione of mouse tissues with a two-photon manner for the naphthalimide moiety and a near-infrared manner for the cyanine moiety, respectively. The results showed that this probe served as a dual-model tissue-imaging agent for the visualization of gl...

Imaging or a Fiber Probe-based Approach? Assessing Different Methods to Detect Near Infrared Autofluorescence for Intraoperative Parathyroid Identification.

Near infrared autofluorescence (NIRAF) can guide intraoperative parathyroid gland (PG) identification. NIRAF detection devices typically rely on imaging and fiber probe-based approaches. Imaging modalities provide NIRAF pictures on adjacent display monitors, while fiber probe-based systems measure tissue NIRAF and provide real-time quantitative information to objectively aid PG identification. Both device types recently gained FDA-approval for PG identification but have never been compared directly.

Design of a Nile red-based NIR fluorescent probe for the detection of hydrogen peroxide in living cells.

In this article, a novel fluorescent probe (NRBE) for detecting HO was developed using benzyl boronic ester as the HO-recognized group and Nile red as the matrix. The probe has several advantages, such as good selectivity, high sensitivity (LOD = 75 nM), good water solubility and emission in the near-infrared region (ex/em:585/670 nm). With the NRBE probe, the endogenous HO in human hepatocellular carcinoma cells BEL-7402, was detected, and the HO generated during the ischemia-reperfusion of the cel...


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