PubMed Journals Articles About "Innovative Collaborative Strategic Approach Proactively Evaluate Update Drug" RSS

22:43 EDT 26th March 2019 | BioPortfolio

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Showing "Innovative Collaborative Strategic Approach Proactively Evaluate Update Drug" PubMed Articles 1–25 of 33,000+

An Innovative, Collaborative, and Strategic Approach to Proactively Evaluate and Update Drug Interactions Based on Prescribing Information of Newly Approved Medicinal Products.

Drug-drug interaction (DDIs) are evaluated using pharmacokinetic (PK) simulation models, clinical studies, and scientific publications throughout drug development. DDIs with Norvir (ritonavir) and combination products (eg, Kaletra [lopinavir/ritonavir]) containing ritonavir as a PK enhancer are relevant, because these drugs could affect exposures of CYP3A4 substrates. Application of algorithms proactively identified recently approved drugs, which potentially cause adverse outcomes when given with drugs cont...

How to deal with drug-induced diarrhoea.

Diarrhoea is a frequent drug adverse event, implicating a number of different treatments. It occurs in an acute setting or even several months after the beginning of the treatment and different pathophysiological mechanisms are involved. It must be proactively suspected and promptly treated, however this diagnosis is often mentioned only after multiple diagnostic tests. In this review we aim to offer a practical approach to promptly identify drug-induced diarrhoea, recognise most common implicated drugs and...

Safety differentiation: emerging competitive edge in drug development.

With increasing expectations to provide evidence of drug efficacy, safety, and cost-effectiveness, best-in-class drugs are a major value driver for the pharmaceutical industry. Superior safety is a key differentiation criterion that could be achieved through better risk:benefit profiles, safety margins, fewer contraindications, and improved patient compliance. To accomplish this, comparative safety assessments using innovative and adaptive nonclinical and clinical outcome-based approaches should be undertak...

Experimental studies on performance of ventilators stored in the Strategic National Stockpile.

The Center for Devices and Radiological Health, Food and Drug Administration (FDA) launched a collaborative initiative with Centers for Disease Control and Prevention (CDC) to gain a better understanding of ventilators that are used during national emergencies. This initiative was intended to test reliability of ventilator devices stored long term in the CDC Strategic National Stockpile (SNS) and also used by the Department of Defense. These ventilators are intended to be used by trained operators to provid...

Strategically Applying New Criteria for Use Improves Management of Peripheral Intravenous Catheters.

Peripheral intravenous catheters (PIVCs) are common devices used across many healthcare settings. This quality improvement project aims to proactively remove PIVCs as soon as possible by empowering nurses and providers to clinically evaluate the necessity of every PIVC on a daily basis on a general hospital medical unit. Specific criteria were established to assess PIVC necessity. Cases of PIVCs not meeting established criteria are escalated to providers for a decision point. The PIVC removal times document...

Visual intelligence education as an innovative interdisciplinary approach for advancing communication and collaboration skills in nursing practice.

Recognizing the relationship of keen observation to communication, critical thinking, and leadership in evidence-based literature, educators have expanded the use of art museums to augment visual intelligence skills. The purpose of this pilot intervention was to evaluate an innovative, interdisciplinary approach for integrating visual intelligence skills into an advanced communications and collaboration course.

Development of Strategic Plans for Advancing Nursing in Korea.

To evaluate the current and prospective status of nursing in Korea and develop a strategic framework and plan to accommodate the increased demands on nurses in the changing health care system.

Anti-cancer Drug Response Prediction Using Neighbor-Based Collaborative Filtering with Global Effect Removal.

Patients of the same cancer may differ in their responses to a specific medical therapy. Identification of predictive molecular features for drug sensitivity holds the key in the era of precision medicine. Human cell lines have harbored most of the same genetic changes found in patients' tumors and thus are widely used in the research of drug response. In this work, we formulated drug-response prediction as a recommender system problem and then adopted a neighbor-based collaborative filtering with global ef...

A study on collaborative telepsychiatric consultations to outpatients of district hospitals of Karnataka, India.

The Indian National Mental Health Survey (NMHS) of 2015-2016 has estimated 13.7% lifetime and 10.6% point prevalence for mental illnesses. It has identified that the treatment gap for mental illnesses ranges between 70% and 92%. Tele-Psychiatric consultations could be an alternative and innovative approach to bridge this gap in low resource settings.

An industry update: the latest developments in therapeutic delivery covering September 2018.

The present industry update covers the period 1-30 September 2018, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. Various technologies using reformulations of know drugs with nanoparticles, hydrogels, aerosols, etc. emerged in new financing rounds (BioTime; CA, USA, SiSaf; Guildford, UK, Cassion Biotech; TX, USA), intellectual property protection (TFF Pharmaceuticals; TX, USA), repackaging (Leiters; CA, USA) and reformulation (Virpax Ph...

Multidisciplinary Collaborative Care in the Management of Patients with Uncontrolled Diabetes: a Systematic Review and Meta-analysis.

Diabetes is a chronic and complex disease that requires a multidisciplinary collaborative care approach.

The use of model constructs to design collaborative health information technologies: a case study to support child development.

Health information technology could provide valuable support for inter-professional collaboration to address complex health issues, but current HIT systems do not adequately support such collaboration. Existing theoretical research on supporting collaborative work can help inform the design of collaborative HIT systems. Using the example of supporting collaboration between child development service providers, we describe a deductive approach that leverages concepts from the literature and analyzes qualitati...

A Systematic Approach to Understanding and Implementing Patient-Centered Care.

In 2014, Family Medicine for America's Health (FMAHealth) began implementing a specialty-wide strategic plan. The FMAHealth Board of Directors created an Engagement Tactic Team and charged the team with two major objectives: (1) to engage patients as partners in transforming primary care, and (2) to strengthen working alliances with other primary care professions and key stakeholders to speak with a unified voice for primary care. The team's first objective sought to engage patients as partners to achieve t...

Pharmacokinetic Variability in Pediatrics and Intensive Care: Toward a Personalized Dosing Approach.

Providing a safe and efficacious drug therapy for large and often heterogeneous populations is a challenging objective in clinical drug development and routine clinical practice. It has been known for years that the optimum dose required for many therapeutic agents among individuals is quite variable. A wide interindividual pharmacokinetic variability was described in clinically relevant populations such as pediatrics and critically ill patients. The aim of this article was to present the main individual fa...

Progress in Inherited Retinal Disease Drug Discovery and Development: A Foundation's Perspective.

Ophthalmic drug discovery and development has enjoyed a recent renaissance, with a major shift away from reformulating old systemic drugs for ocular use to de novo discovery of drugs for specific ocular disease targets. This shift, coupled with a revolution in molecular biology and genetic sequencing, has uncovered an unprecedented number and variety of novel targets for therapeutic intervention in eye disease. With such a treasure chest of new science to pursue, it also creates a new challenge for translat...

The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions.

As the name suggests, drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued and/or shelved drugs, and drug candidates currently in clinical development. Although not a recent concept, drug repurposing has gained momentum over the past few years and several drugs have been successfully repurposed. Here, we summarize the drug repurposing landscape from 2012 to 2017, with a major focus on repurposed drugs, collaborative opportunities, and funding opportunities specifi...

A mixed-methods approach to strategic planning for multi-benefit regional water infrastructure.

Finding regional solutions for water infrastructure and other environmental management challenges requires coordination, communication, and a shared understanding among different stakeholders. To develop a more versatile and collaborative decision-making process for nutrient management in the San Francisco Bay Area, we used a mixed-methods approach consisting of stakeholder analysis with cluster analysis, multi-criteria decision analysis (MCDA), and scenario planning. These methods allowed us to identify ag...

In silico screening for solid dispersions: the trouble with solubility parameters and χFH.

The problem of predicting small molecule-polymer compatibility is relevant to all areas of materials science. Computational methods based on Hildebrand and Hansen solubility parameters, and the estimation of the Flory-Huggins parameter, χ, have proliferated across the literature. Focusing on the need to develop amorphous solid dispersions to improve the bioavailability of poorly soluble drug candidates, an innovative, high throughput 2D printing method has been employed to rapidly assess the compatibility ...

Midwifery continuity of carer: Developing a realist evaluation framework to evaluate the implementation of strategic change in Scotland.

Midwifery continuity of carer (MCC) models result in better clinical outcomes for women and offer midwives a superior way of working when compared to other models of maternity care. Implementing a MCC model, a key recommendation of the Scottish Government Maternity and Neonatal Strategy Best Start, requires significant restructuring of maternity services and changes to midwives' roles. Careful evaluation is therefore required to monitor and understand how the policy affects care providers and users. Realist...

Initiation and engagement as mechanisms for change caused by collaborative care in opioid and alcohol use disorders.

To assess the mechanism by which a collaborative care (CC) intervention improves self-reported abstinence among primary care patients with opioid and alcohol use disorders (OAUD) compared to treatment as usual.

Linkage to care of HIV positive clients in a community based HIV counselling and testing programme: A success story of non-governmental organisations in a South African district.

Although current data projects South Africa potentially meeting the UN target to test 90% of all people living with HIV by 2020, linking them to HIV care remains a big challenge. In an effort to increase linkage to care (LTC) of HIV positive clients an innovative collaborative intervention between two non-governmental organisations was developed and implemented between 2016 and 2017. This paper investigated the outcome of this collaborative intervention.

Using Drug Expression Profiles and Machine Learning Approach for Drug Repurposing.

The cost of new drug development has been increasing, and repurposing known medications for new indications serves as an important way to hasten drug discovery. One promising approach to drug repositioning is to take advantage of machine learning (ML) algorithms to learn patterns in biological data related to drugs and then link them up to the potential of treating specific diseases. Here we give an overview of the general principles and different types of ML algorithms, as well as common approaches to eval...

Challenge Based Learning nurtures creative thinking: An evaluative study.

The demand for more creative and innovative nurses and together with the rapid expansion of nurse education in Mainland China have called for new approaches to student learning. Challenge Based Learning, an active student-directed approach was incorporated into an elective course in an undergraduate nursing programme. Initially, the students were given some big ideas about the real world. They worked together in small groups to identify the most challenging problems from these ideas, develop some innovative...

An Innovative Approach to Assess Similarity Between Sex Partners.

We present a simple, comprehensive method for assessing similarity between sex partners of a participant and demonstrate its application using data collected in 2015 as part of CDC's National HIV behavioral surveillance (NHBS) among persons who inject drugs (PWID). We found that the pairwise similarity between sex partners of a survey participant was high. The similarity between second-to-last and third-to-last partners in the past 3 months was significantly higher than that between last and second-to-last...

Novel Neural Network Approach to Predict Drug-Target Interactions Based on Drug Side Effects and Genome-Wide Association Studies.

We propose a novel machine learning approach to expand the knowledge about drug-target interactions. Our method may help to develop effective, less harmful treatment strategies and to enable the detection of novel indications for existing drugs.

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