Advertisement

Topics

PubMed Journals Articles About "Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin" RSS

21:32 EDT 18th March 2019 | BioPortfolio

Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin articles that have been published worldwide.

More Information about "Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin" on BioPortfolio

We have published hundreds of Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin news stories on BioPortfolio along with dozens of Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin Clinical Trials and PubMed Articles about Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin Companies in our database. You can also find out about relevant Liver Targeted Delivery Entecavir Glycyrrhetinic Acid Based Albumin Drugs and Medications on this site too.

Showing "Liver targeted delivery entecavir glycyrrhetinic acid based albumin" PubMed Articles 1–25 of 48,000+

Liver targeted co-delivery of entecavir and glycyrrhetinic acid based on albumin nanoparticle to enhance the accumulation of entecavir.

Hepatitis B, one of the most common contagious viral hepatitis with high infection rate, is challenging to treat. Although the treatment for hepatitis B has been improved over the years, many therapeutic drugs still have either severe adverse effects or insufficient effectiveness via systemic administration. In this study, we confirmed that glycyrrhetinic acid can enhance the accumulation of entecavir in HepaRG cell and liver. Then we constructed a novel albumin nanoparticle co-loading entecavir and glycyrr...


Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid.

Diabetes mellitus is a chronic metabolic disorder characterized by insulin deficiency and impaired glucose metabolism. Overexpression of cAMP response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) plays an important role in high gluconeogenesis in patients with diabetes type II. Using RNA interference technology for silencing CRTC2 gene expression could be helpful in controlling the level of blood glucose and gluconeogenesis. In this study, we designed a siRNA delivery platf...

Recent insights into the development of nucleic acid-based nanoparticles for tumor-targeted drug delivery.

Cancer is one of the most abundant causes of death in the world due to its characteristic features such as indefinite growth of cells, invasion of healthy tissues, and also metastasis. Conventional treatments of both chemotherapy and radiation have intense side effects and kills cancer cells along with normal healthy cells. Therefore, targeted drug delivery system has become the most suitable way to optimize all the side effects involved in conventional drug delivery systems. Among the various targeted drug...


Lactobionic/folate dual-targeted amphiphilic maltodextrin-based micelles for targeted co-delivery of sulfasalazine and resveratrol to hepatocellular carcinoma.

In this study, promising approaches of dual-targeted micelles and drug-polymer conjugation were combined to enable injection of poorly soluble anti-cancer drugs together with site-specific drug release. Ursodeoxycholic acid (UDCA) as a hepatoprotective agent was grafted to maltodextrin (MD) via carbodiimide coupling to develop amphiphilic maltodextrin-ursodeoxycholic acid (MDCA)-based micelles. Sulfasalazine (SSZ), as a novel anti-cancer agent, was conjugated via a tumor-cleavable ester bond to MD backbone ...

Albumin nanoparticles conjugates binding with glycan - A strategic approach for targeted drug delivery.

Understanding the transcytosis phenomenon through albumin binding receptor (glycoproteins) is an important step towards targeted drug delivery research. The transcytosis of bovine serum albumin (BSA) occurs through its uptake by binding to glycoprotein (gp60) present on the endothelial cell membrane. gp60 possess abundant glycans like N-acetylneuraminic acid (sialic acid, NANA), l-fucose (FUC), N-acetyl glucosamine (NAG), d-mannose (MAN) and d-galactose (GAL). Hence, the objective of the present study was t...

A pH-Responsive Glycyrrhetinic acid-Modified Small Molecular Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC).

Herein, we reported a glycyrrhetinic acid (GA)-decorated small molecule conjugate for pH-triggered near infra-red (NIR) fluorescence imaging of hepatocellular carcinoma (HCC). Our ''in vitro'' studies demonstrated that NIR-GA was efficiently up-taken by liver cancer cell lines such as HepG2 and Huh7 through GA receptors-mediated endocytic pathway. As suggested by co-localization studies, NIR-GA mainly localized into the lysosome where acidic pH results in activation of fluorescent dye via H+-triggered spiro...

Endogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapy.

Targeted delivery and accumulation of chemotherapeutics to tumor sites is in high demand and extremely challenging for anticancer therapy. Studies show that albumin is actively recruited into tumor tissue overexpressing albumin-binding proteins including secreted protein acidic and rich in cysteine (SPARC) and gp60. Herein, a novel redox-responsive paclitaxel-loaded micelle system with the modification of ABD035, which specifically and strongly binds to albumin, is designed to combine the strengths of album...

Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo.

Targeted tumor imaging and efficient specific gene delivery in vivo has been one of the main challenges in gene-based cancer diagnosis and therapy. Herein, we engineered a citric acid-based polymer with intrinsical photoluminescence and gene loading capacity to achieve targeted delivery of siRNA and tumor imaging in vitro and in vivo. The multifunctional platform was formed from the self-assembling of poly (citric acid)-polymine conjugated with folic acid and rhodamine B (PPFR). PPFR showed stable photolumi...

Tumor-targeting micelles based on folic acid and α-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery.

Tumor-targeting micelles for the delivery of paclitaxel (PTX) were developed based on folic acid and α-tocopherol succinate conjugated hyaluronic acid (FA-HA-TOS). The conjugate FA-HA-TOS was synthesized by an esterification reaction and was characterized by proton nuclear magnetic resonance (H NMR) and Fourier transform infrared (FT-IR) analysis. The conjugate self-assembles into nanosized micelles in aqueous medium with a critical micellar concentration (CMC) of 1.12 × 10 mg/mL. The FA-HA-TOS mice...

Modified cells as potential ocular drug delivery systems.

Drug delivery to ocular targets is problematic, especially in retinal disease treatment. Therefore, targeted drug delivery, prolonged drug action, and minimally invasive treatments are needed. In this review, we describe cell technologies for drug delivery. These technologies are based on genetic engineering and nongenetic-based approaches for cell modification. In principle, cell technologies enable targeted delivery, long drug action, and minimally invasive administration, but they have only been sparsely...

Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease.

Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae and is responsible for increased aortic stiffness and subsequent cardiovascular events. Current treatments for calcification, particularly in CKD, are predominantly focused on regulating the mineral disturbance and other risk factors. Ethylene diamine tetraacetic acid (EDTA), a chelating agent, can resorb mineral deposits, but the syst...

Albumin: The Cons.

Intravenous albumin infusions have long been considered an important option in the treatment of patients with cirrhosis and ascites . Many studies have shown that 20% Human Albumin Solution (HAS) improves circulatory function and it is therefore recommended in international guidelines worldwide for use in hepatorenal syndrome (HRS), spontaneous bacterial peritonitis (SBP), as well as in preventing post paracentesis circulatory dysfunction following large volume paracentesis (LVP) . Albumin has also been rep...

Anti-Inflammatory 18β-Glycyrrhetinin Acid Derivatives Produced by Biocatalysis.

In this study, the biocatalysis of 18-glycyrrhetinic acid by two strains of filamentous fungi, namely AS 3.2893 and AS 3.2695, was investigated. Scaled-up biotransformation reactions yielded 14 metabolites. Their structures were established based on extensive nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data analyses, and seven of them are new compounds. The two fungal strains exhibited distinct biocatalytic features. could catalyze hydroxylation and carbonylat...

Fullerene-based delivery systems.

With the development of new drugs, there have been many attempts to explore innovative delivery routes. Targeted delivery systems are a desired solution designed to overcome the deficiency of routine methods. To transform this idea into reality, a wide range of nanoparticles has been proposed and studied. These nanoparticles should interact well with biological environments and pass through cell membranes to deliver therapeutic molecules. One of the pioneer classes of carbon-based nanoparticles for targeted...

Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma.

In recent years, green nanomedicines have made transformative difference in cancer therapy researches. Herein, we propose dual-functionalized spray-dried casein micelles for combined delivery of two phytochemicals; berberine (BRB) and diosmin (DSN) as targeted therapy of hepatocellular carcinoma (HCC). The nanomicelles enabled parenteral delivery of the poorly soluble DSN via its encapsulation within their hydrophobic core. Moreover, sustained release of the water soluble BRB was attained by hydrophobic ion...

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein.

Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is facilitated by high pressure and volumes, also known as hydrodynamic delivery. In this study, we compare the efficacy and specificity of delivery of vesicular stomatitis virus G glycoprotein (VSV-G) pseudotyped lentiviral vectors to mouse liver by a number of in...

Application of polydopamine in tumor targeted drug delivery system and its drug release behavior.

Inspired by the bionics of marine mussels, polydopamine (PDA), a new polymer with unique physicochemical properties was discovered. Due to its simple preparation, good biocompatibility, unique drug-loading methods, PDA has attracted tremendous attentions in field of drug delivery and imaging, and the combination of chemotherapy and other therapies or diagnostic methods, such as photothermotherapy (PTT), photoacoustic imaging (PAI), magnetic resonance imaging (MRI), etc. As an excellent drug carrier in tumor...

Corrigendum to "Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo" Biomaterials 199 (2019) 10-21.

Targeted delivery of nitric oxide via a 'bump-and-hole'-based enzyme-prodrug pair.

The spatiotemporal generation of nitric oxide (NO), a versatile endogenous messenger, is precisely controlled. Despite its therapeutic potential for a wide range of diseases, NO-based therapies are limited clinically due to a lack of effective strategies for precisely delivering NO to a specific site. In the present study, we developed a novel NO delivery system via modification of an enzyme-prodrug pair of galactosidase-galactosyl-NONOate using a 'bump-and-hole' strategy. Precise delivery to targeted tissu...

Oral siRNA Delivery Using Dual Transporting Systems to Efficiently Treat Colorectal Liver Metastasis.

Oral siRNA delivery is an ideal way to translate siRNA therapeutic effects in the clinic due to its ability to be administered in convenient and multiple dosages. However, an effective oral delivery system requires overcoming both a hostile gastrointestinal (GI) environment and non-specific targeting. Here, an HTsRP-NC system is a new oral siRNA delivery system consisting of a siRNA/protamine (sRP) nano-complex protected by a multi-functional hyaluronic acid-taurocholic acid (HA-TCA) conjugate. The HTsRP-NC...

Fluoropolymers for intracellular and in vivo protein delivery.

The design of efficient and universal carriers to transport proteins into cells is highly desirable in the development of biotherapeutics. However, intracellular protein delivery remains a major challenge owing to the multiple barriers in protein delivery process, such as protein encapsulation, endocytosis, endosomal escape and intracellular protein release. Recently, it was reported that fluorination on polymers is beneficial for their self-assembly and intracellular trafficking. We hypothesize the fluorop...

Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy.

Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for reverse the drug resistance and drug efflux of CSCs, but in vivo nucleus-targeted drug delivery has been challenging. Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further ...

Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases.

Bile acid (BA) has an important role in signal transduction, and has clinical applicability as an early biomarker for the diagnosis and prevention of cholestatic liver disease, which has a close relationship with BA homeostasis. Understanding the guarantee factors, function, and regulation of BA homeostasis under physiological conditions and in cholestatic liver diseases could provide novel therapeutic approaches for treating cholestatic liver injury. Here, we review potential biomarkers of BA, and new ther...

Long-term administration of human albumin improves survival in patients with cirrhosis and refractory ascites.

In patients with liver cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long-term albumin administration on emergent hospitalization and mortality.

Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging.

Although liver transport routes have been extensively studied in rodents, live imaging under in situ and in vivo conditions of large volumes is still proven to be difficult. In this study, we took advantage of the optical transparency of zebrafish and their small size to explore their usefulness for correlative imaging studies and liver transport experimentations. First, we assessed the micro-architecture of the zebrafish liver and compared its fine structure to the rodent and humans' literature. Next, we i...


Advertisement
Quick Search
Advertisement
Advertisement