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PubMed Journals Articles About "MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY" RSS

01:35 EST 22nd January 2019 | BioPortfolio

MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY articles that have been published worldwide.

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We have published hundreds of MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY news stories on BioPortfolio along with dozens of MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY Clinical Trials and PubMed Articles about MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY Companies in our database. You can also find out about relevant MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY Drugs and Medications on this site too.

Showing "MICRODOSIMETRIC MEASUREMENT SECONDARY RADIATION PASSIVE SCATTERED PROTON THERAPY" PubMed Articles 1–25 of 21,000+

Patterns of Local-Regional Failure after Intensity-Modulated Radiation Therapy or Passive Scattering Proton Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer.

We compared differences in patterns of local-regional failure, and the influence of adaptive planning on those patterns, in patients given passive scattering proton therapy (PSPT) vs. intensity-modulated photon therapy (IMRT) for non-small cell lung cancer.


Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk than Mean Lung Dose: Secondary Analysis of a Randomized Trial.

To confirm the superiority of effective dose (D) over mean lung dose (MLD) for predicting risk of radiation pneumonitis (RP), using data from patients on a randomized trial of intensity-modulated radiotherapy (IMRT) versus passively scattered proton therapy (PSPT).

SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field.

With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of the relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE of 1.1 for proton fields irrespective of their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure beam characteristics and quantify or be indicative of biological ...


"Radiation-induced moyamoya syndrome after proton therapy in a child with clival craniopharyngioma: natural history and surgical treatment".

Proton therapy has proven to be effective and safe in the treatment of radioresistant skull base tumors such as chordomas. Thanks to the peculiar physical properties of the proton beam, the radiation energy is delivered in a narrow space called the Bragg peak and the surrounding normal tissues receive a minimal amount of the radiation dose. This is important to lower the risk of radiation-induced damage, especially in children. However, local adverse effects in proximity to the target volume may occur. In p...

Investigations of line scanning proton therapy with dynamic multi-leaf collimator.

Scanning proton therapy has dosimetric advantage over passive treatment, but has a large penumbra in low-energy region. This study investigates the penumbra reduction when multi-leaf collimators (MLCs) are used for line scanning proton beams and secondary neutron production from MLCs.

The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care.

Proton therapy is increasingly prescribed for cancer treatment given its potential for improvements in clinical outcomes and toxicity reduction; however, insurance coverage continues to be a barrier to patient access. This study examined insurance approval and appeal outcomes at a large volume proton therapy center to clarify the process and identify areas for improvement.

Secondary Neutron Dose from a Dynamic Collimation System During Intracranial Pencil Beam Scanning Proton Therapy: A Monte Carlo Investigation.

Patients receiving pencil beam scanning (PBS) proton therapy with the addition of a Dynamic Collimation System (DCS) are potentially subject to additional neutron dose from interactions between the incident proton beam and the trimmer blades. This study investigates the secondary neutron dose rates for both single field uniform dose and intensity modulated proton therapy treatments. Secondary neutron dose distributions were calculated for both a dynamically collimated and uncollimated, dual-field chordoma...

Effect of anatomical change on dose distribution during radiotherapy for maxillary sinus carcinoma: passive scattering proton therapy versus volumetric-modulated arc therapy.

Maxillary sinus carcinomas are anatomically situated next to many organs at risk (OARs), and anatomical change is often observed during radiotherapy. We analyzed the effect of anatomical change on dose distribution of passive scattering proton therapy (PSPT) and volumetric-modulated arc therapy (VMAT) for 20 patients.

A roadmap for important centers of growth in the pediatric skeleton to consider during radiation therapy and associated clinical correlates of radiation-induced growth toxicity.

With the increasing use of advanced radiation techniques such as intensity modulated radiation therapy, stereotactic radiation therapy, and proton therapy, radiation oncologists now have the tools to mitigate radiation-associated toxicities. This is of utmost importance in the treatment of a pediatric patient. To best utilize these advanced techniques to mitigate radiation-induced growth abnormalities, the radiation oncologist should be equipped with a nuanced understanding of the anatomy of centers of grow...

The Promise of Proton Therapy for Central Nervous System Malignancies.

Radiation therapy plays a significant role in management of benign and malignant diseases of the central nervous system. Patients may be at risk of acute and late toxicity from radiation therapy due to dose deposition in critical normal structures. In contrast to conventional photon delivery techniques, proton therapy is characterized by Bragg peak dose deposition which results in decreased exit dose beyond the target and greater sparing of normal structure which may reduce the rate of late toxicities from ...

A Quantitative Clinical Decision-support Strategy Identifying Which Oropharyngeal Head and Neck Cancer Patients may Benefit the Most from Proton Radiation Therapy.

Developing a quantitative decision-support strategy estimating the impact of normal tissue complications from definitive radiation therapy (RT) for head and neck cancer (HNC). We developed this strategy to identify oropharyngeal HNC patients that may benefit most from receiving proton RT.

CHARACTERIZATION OF A LITHIUM FORMATE EPR-DOSIMETRY SYSTEM FOR PROTON RADIATION THERAPY.

The specific aim for the characterization of the lithium formate dosimetry system is to determine response and stability in a proton beam. The long-term goal for this investigation is an audit system for proton therapy like the end-to-end dose determinations performed for radiotherapy with photons. For a 150-MeV proton beam, the dose response was found to be linear in the dose interval 0-8.8 Gy. The accuracy of dose reconstruction was controlled in a blind test, in which the dose of 6.63 Gy was measured in ...

Investigation of optimal physical parameters for precise proton irradiation of orthotopic tumors in small animals.

The lack of evidence of biomarkers identifying patients that would benefit from proton therapy has driven the emergence of preclinical proton irradiation platforms using advanced small-animal models to mimic clinical therapeutic conditions. This study aims to determine the optimal physical parameters of the proton beam with a high radiation targeting accuracy, since small-animal tumors can reach millimetric dimensions at a maximum depth of about 2 cm.

Secondary Malignancies in the Era of High-Precision Radiation Therapy.

Although modern radiation therapy delivers a localized distribution of ionizing energy that can be used to cure primary cancers for many patients, the inevitable radiation exposure to non-targeted normal tissue leads to a risk of a radiation-related new cancer. Modern therapies often produce a complex spectrum of secondary particles, both charged and uncharged, that must be considered both in their physical radiation transport throughout the patient and their potential to induce biological damage, which dep...

Insurance Approval for Proton Beam Therapy and its Impact on Delays in Treatment.

Prior authorization (PA) has been widely implemented for proton beam therapy (PBT). We sought to determine the association between PA determination and patient characteristics, practice guidelines, and potential treatment delays.

A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors.

A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method is based on the different LET response of two different lithium fluoride thermoluminescent detectors (LiF:Mg,Ti and LiF:Mg,Cu,P) for measuring charged particles. The relative efficiency of the two detector types was predicted using the recently developed Microdosimetric d(z) Model in combination with the Monte Carlo code P...

Optimal combined proton-photon therapy schemes based on the standard BED model.

This paper investigates the potential of combined proton-photon therapy treatments in radiation oncology, with a special emphasis on fractionation. Several combined modality models, with and without fractionation, are discussed, and conditions under which combined modality treatments are of added value are demonstrated analytically and numerically. The combined modality optimal fractionation problem with multiple normal tissues is formulated based on the Biologically Effective Dose (BED) model and tested on...

Towards a novel dosimetry system using acrylic disk radiation sensor for proton pencil beam scanning.

Fabricate an acrylic disk radiation sensor (ADRS) and characterize the photoluminescence signal generated from the optical device as basis for the development and evaluation of a new dosimetry system for pencil beam proton therapy.

Energy Spectra of Protons and Generated Secondary Electrons around the Bragg Peak in Materials of Interest in Proton Therapy.

The number and energy of secondary electrons generated around the trajectories of swift protons interacting with biological materials are highly relevant in proton therapy, due to the prominent role of low-energy electrons in the production of biodamage. For a given material, electron energy distributions are determined by the proton energy; and it is imperative that the distribution of proton energy at depths around the Bragg peak region be described as accurately as possible. With this objective, we simul...

Reducing X-ray imaging for proton postmastectomy chest wall patients.

Proton postmastectomy radiation therapy (PMRT) patients are positioned daily using surface imaging with additional x-ray imaging for confirmation. This study aims to investigate whether weekly x-ray imaging with daily surface imaging, as performed for photon treatment, is sufficient to maintain PMRT patient positioning fidelity.

Introducing proton track-end objectives in intensity modulated proton therapy optimization to reduce linear energy transfer and relative biological effectiveness in critical structures.

We propose the use of proton track-end objectives in intensity modulated proton therapy (IMPT) optimization to reduce the linear energy transfer (LET) and the relative biological effectiveness (RBE) in critical structures.

Measurement of peripheral dose to pelvic region and associated risk for cancer development after breast intraoperative electron radiation therapy.

This study aimed to measure received dose to the pelvic region of patients during breast intraoperative electron radiation therapy (IOERT). Furthermore, we compared the findings with those of external beam radiation therapy. Finally, secondary ovary and uterus cancer risks following breast IOERT were estimated. In the current study, the received dose to the pelvic surface of 18 female patients during breast IOERT boost were measured by thermoluminescent dosimeter (TLD-100) chips. All patients were treated w...

A model-based approach to predict short-term toxicity benefits with proton therapy for oropharyngeal cancer.

The aim of this study was to generate normal tissue complication probability (NTCP) models in patients treated with either proton beam therapy (PBT) or intensity-modulated radiotherapy (IMRT) for oropharynx cancer, and to use a model-based approach to investigate the added value of PBT in preventing treatment complications.

Proton therapy for skull base tumors: A review of clinical outcomes for chordomas and chondrosarcomas.

Skull base chordomas and chondrosarcomas are rare tumors traditionally treated by surgical resection and adjuvant radiation therapy (RT). We will discuss data evaluating clinical outcomes of proton therapy in the treatment of skull base chordomas and chondrosarcomas.

Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation.

Radiation therapy is an important alternative treatment for advanced cancer. The aim of the current study was to disclose distinct alterations of the biological characteristics of gene expression features in pancreatic cancer cells, MIAPaCa-2, following proton and X-ray irradiation.


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