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Microbe Inotech Laboratories PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Microbe Inotech Laboratories articles that have been published worldwide.
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Plant-microbe interactions are great model systems to study co-evolutionary dynamics across multiple timescales. However, mechanistic research on plant-microbe interactions has often been conducted with little consideration of evolutionary concepts and methods. Conversely, evolutionary research has rarely integrated the range of mechanisms and models from the molecular plant-microbe interactions field. In recent years, the incipient field of evolutionary molecular plant-microbe interactions (EvoMPMI) has em...
Plants and microbes are dependent on chemical signals as a means of inter-kingdom communication. There are two predicted paths for the evolution of these signals. Ritualization, the evolution of signals from cues, is the oft-assumed pathway for the evolution of plant-microbe communication systems. However, plant-microbe signaling may evolve from coercive interactions as well, a process known as sensory manipulation. Here, we aim to highlight the prevalence of coercive interactions and discuss sensory manipu...
Complex interactions between pathogenic bacteria, the microbiota, and the host can modify pathogen physiology and behavior. We describe two different experimental approaches to study microbe-microbe interactions in in vitro systems containing surface-associated microbial populations. One method is the application of RNA sequencing (RNA-seq) to determine the transcriptional changes in pathogenic bacteria in response to microbial interspecies interactions. The other method combines flow cell devices for bacte...
Natural products have long played a pivotal role in the development of therapeutics for a variety of diseases. Traditionally, soil and marine environments have provided a rich reservoir from which diverse chemical scaffolds could be discovered. Recently, the human microbiome has been recognized as a promising niche from which secondary metabolites with therapeutic potential have begun to be isolated. In this Review, we address how the expansive history of identifying bacterial natural products in other envi...
No immunogen has been found that elicits a broadly neutralizing antibody (bNAb) response sufficient for development into an HIV vaccine. In this issue of Cell Host and Microbe, Zhang et al. (2018) rationally design an HIV envelope glycoprotein variant that provides new hope that such an immunogen may be attainable.
The presence of unused dyes and dye degradation intermediates in the textile industry wastewaters is the major challenge in its treatment. A wide range of treatments including various physicochemical processes are used for this wastewater. Incomplete dye degradation results in hazardous colorless aromatic amine intermediates that are teratogenic in nature. A synergistic plant-microbe system operated in a sequential anaerobic-aerobic mode was evaluated for the complete degradation of a model azo dye methyl r...
Immune responses and metabolic regulation are tightly coupled in animals, but the underlying mechanistic connections are not fully understood. In this issue of Cell Host & Microbe, Lee et al. (2018) reveal how sustained ROS production in the gut depends on an upstream metabolic switch.
How does the immune system maintain a balance between preserving a beneficial microbiome and protecting against pathogens while also inducing effective, yet not damaging, responses? In this issue of Cell Host & Microbe, Charroux et al. (2018) reveal that, in Drosophila, this task is performed by three isoforms of PGRP-LB, a peptidoglycan-hydrolyzing amidase.
There is a wide practice variation of used methods and outcomes in IUI in fertility laboratories. Standardization of the IUI procedure is important for reducing inconsistency among laboratories in counseling infertile couples and in pregnancy results. The aim of the study was to evaluate the currently used laboratory procedures of IUI in Dutch fertility laboratories and their effect on IUI pregnancy results. Additionally, the methods for semen analysis (SA) were evaluated, as SA is related to IUI in terms o...
The Interlaboratory Study of Novel Flame Retardants (INTERFLAB 2) was conducted by 20 laboratories in 12 countries to test the precision and accuracy of the analysis of 24 "novel" flame retardants (NFRs). Laboratories analyzed NFRs in injection-ready test mixtures, in extracts of residential dust, and in residential dust to evaluate the influence of dust handling and extraction. For test mixtures, mean reported concentrations of PBT, PBEB, EH-TBB, TBBPA, TBDP-TAZTO, TBOEP, α-TBCO, β-DBE-DBCH, and total HB...
In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.
While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.
Commensal bacteria protect against invading pathogens using many strategies. In this issue of Cell Host & Microbe, Paharik et al. (2017) find that a commensal blocks Staphylococcus aureus colonization by producing a signal to shut down virulence.
Phenotypic screening methods have had a profound impact on antimalarial drug development, but assays that predict which compounds might provide a radical cure have remained elusive. In this issue of Cell Host & Microbe, Gural et al. (2018) report hypnozoite culturing and systems to study these elusive, yet deadly, parasites.
Dynamics of phages and bacteria in the gut may play key roles in human health. In this issue of Cell Host & Microbe, De Sordi et al. (2017) provide insights into phage-bacteria interactions, finding that microbial communities contribute to phage persistence in the mammalian gut by supplying new hosts.
The attachment of bacteria to roots constitutes the first physical step in many plant-microbe interactions. These interactions exert both positive and negative influences on agricultural systems depending on whether a growth-promoting, symbiotic, or pathogenic relationship transpires. A common biphasic mechanism of root attachment exists across agriculturally important microbial species, including Rhizobium, Agrobacterium, Pseudomonas, Azospirillum and Salmonella. Attachment studies have revealed how plant-...
To evaluate the failure rate and performance of cell-free DNA (cfDNA) testing, mainly in terms of detection rates for trisomy 21, performed by 2 laboratories using different analytical methods.
The gut microbiome is comprised of microbes from multiple kingdoms, including bacteria, but also fungi, viruses, and perhaps other agents. In this issue of Cell Host & Microbe, Jiang et al. (2017) reveal that fungal monocolonization after antibiotic-mediated depletion of intestinal bacteria prevents colitis and influenza, thus highlighting beneficial roles of fungi.
In the absence of IL-10, Helicobacter hepaticus (Hh) induces colitis. In this issue of Cell Host & Microbe, Danne et al. (2017) report that Hh produces a polysaccharide that induces an anti-inflammatory response in macrophages, providing a potential clue as to why this bacterium is normally tolerated by the immune system.
In this issue of Cell Host & Microbe, Wilmore et al. (2018) co-housed isogenic mouse populations, uncovering commensal bacteria-induced serum IgA and IgA-producing bone marrow plasma cells as critical components of resistance against sepsis. They further identified gut microbial taxa that may account for the induction of this protective system.
To determine the extent and distribution of workforce shortages within the nation's medical laboratories.
Successive synchronized cycles of Plasmodium replication in the host's blood causes the symptoms of malaria and fuels disease transmission. In this issue of Cell Host & Microbe, Hirako et al. (2018) reveal that host circadian rhythms of inflammation and metabolism are responsible for the timing of cycles of parasite replication.
Listeriolysin O (LLO) perforates host vacuoles, allowing Listeria monocytogenes to escape to the cytosol. How cytosolic LLO prevents cell lysis was not understood. In this issue of Cell Host & Microbe, Chen et al. (2018) show that a PEST sequence prevents cytotoxicity by mediating LLO endocytosis from the plasma membrane.
Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonomous immunity in the intestinal mucosa.
Bacterial sensing is important for perceiving environmental cues and activating responses. In this issue of Cell Host & Microbe, Hertzog et al. (2018) show that group A Streptococcus can couple the ability to respond to host cues with autoinduction of a quorum sensing system, leading to killing of bacterial competitors.