PubMed Journals Articles About "Milestone" RSS

04:00 EDT 26th April 2018 | BioPortfolio

Milestone PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Milestone articles that have been published worldwide.

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Showing "Milestone" PubMed Articles 1–25 of 42

A new milestone for STIs in the USA.

Is pravastatin a milestone in the prevention and treatment of preeclampsia?

Validity of Simulation-Based Assessment for Accreditation Council for Graduate Medical Education Milestone Achievement.

The Accreditation Council for Graduate Medical Education requires biannual evaluation of anesthesiology residents on 25 subcompetency milestones. Some milestone domains are particularly challenging to repeatedly and reliably observe during clinical care. Simulation-Based Milestones Assessment (SBMA) may help overcome these challenges. However, few studies have examined the external validation of simulation assessment scores (ie, the relationships between simulation-based assessment scores and other standard...

Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: a retrospective longitudinal analysis.

Understanding HIV persistence in treated patients is an important milestone towards drug-free control. We aimed to analyze total HIV DNA dynamics and influencing factors in Japanese patients who received more than a decade of suppressive antiretroviral treatment.

Single tooth anesthesia versus conventional anesthesia: a cross-over study.

The aim of the present study was to compare an electronic device, the Wand Injection System (Milestone Scientific Livingstone), with conventional anesthesia in terms of the following: pain sensation during anesthetic injection; effectiveness in achieving adequate anesthesia for a complete painless dental treatment; post-operative discomfort; and patient's anxiety toward dental treatment.

Appraising Medical Literature: The Effect of a Structured Journal Club Curriculum Using The Lancet Handbook of Essential Concepts in Clinical Research on Resident Self-Assessment and Knowledge in Milestone-Based Competencies.

Training in literature appraisal and statistical interpretation is one of the residency training requirements outlined by the Accreditation Council for Graduate Medical Education. Frequently, a journal club format is used to teach this competency although this teaching modality is not standardized or well studied in regard to its efficacy.

Endoscopic transorbital route to the petrous apex: a feasibility anatomic study.

While the subtemporal approach represents the surgical module milestone designed to reach the petrous apex, a novel ventral route, which is the superior eyelid endoscopic transorbital approach, has been proposed to access the skull base. Accordingly, we aimed to evaluate the feasibility of this route to the petrous apex, providing a qualitative and quantitative analysis of this relatively novel pathway.

A competency-based simulation curriculum for surgical resident trauma resuscitation skills.

Evidence-based curricula for nonprocedural simulation training in general surgery are lacking. Residency programs are required to implement simulation training despite this shortcoming. The goal of this project was the development of a simulation curriculum that measurably improves milestone performance and replaces traditional experienced-based training with a competency-based model.

Tailoring Optical Gradient Force and Optical Scattering and Absorption Force.

The introduction of the concept of gradient force and scattering and absorption force is an important milestone in optical trapping. However the profiles of these forces are usually unknown, even for standard setups. Here, we successfully calculated them analytically via multipole expansion and numerically via Mie theory and fast Fourier transform. The former provides physical insight, while the latter is highly accurate and efficient. A recipe to create truly conservative energy landscapes is presented. Th...

Motor Skill Development Alters Kinematics and Co-Activation Between Flexors and Extensors of Limbs in Human Infant Crawling.

Hands and knees crawling is an important motor developmental milestone but the current clinical measures of motor function during crawling stage are relatively subjective. Objective metrics using kinematics and electromyography (EMG) in infant crawling may provide more stable and accurate measures of such developmental milestone, demonstrating changes in locomotion during age span. The purpose of this paper was to determine whether joint kinematics and the underlying co-activation between flexor and extenso...

Breast Reconstruction: A Century of Controversies and Progress.

Breast cancer treatment has dramatically changed over the past century. Since Halsted's first description of radical mastectomy in 1882, breast reconstruction has evolved slowly from being considered as a useless or even dangerous procedure by surgeons to the possibility nowadays of reconstructing almost any kind of defect. In this review on the development of breast reconstruction, we outline the historical milestone innovations that led to the current management of the mastectomy defect in an attempt to u...

Effects of storage conditions on hatchability, embryonic survival and cytoarchitectural properties in broiler from young and old flocks.

Storing eggs at low temperature prior to incubation is common practice in the broiler hatchery industry; however, prolonged storage (beyond 7 d) is known to increase early embryonic mortality and reduce chick quality and performance. To better understand the basis of this mortality, we previously published milestone criteria to evaluate morphological and cellular properties of the freshly laid embryo. Using these criteria, in the present study we checked the effects of storage at 18°C and 12°C for up to 2...

Polarization study about a telescope-based transmitter for quantum communication.

We studied the polarization evolution of a reflective telescope designed for the quantum satellite Micius. The change in polarization extinction ratio (PER) of quantum light was derived and calculated. The PER deterioration caused by increase of incidence angle was calculated to determine the boundary conditions for the system design. The performance of the Micius prototype was evaluated both theoretically and experimentally to verify the viability of our optical design. Minimum and maximum PERs of 38 and 5...

Integrating data from the IMPD/IB. A new tool for translational integration of preclinical effects.

The first administration of a new compound in humans is an important milestone. A major source of information for the researcher is the 'investigator's brochure' (IB). Such a document, has a size of several hundred pages. The IB should enable investigators or regulators to independently assess the risk-benefit of the proposed trial but the size and complexity makes this difficult. This article offers a practical tool for the integration and subsequent communication of the complex information from the IB or ...


In the last few years there has been a huge progress in a development of printing techniques and their application in pharmaceutical sciences and particularly in the pharmaceutical technology. The variety of printing methods makes it necessary to systemize them, explain the principles of operation, and specify the possibilities of their use in pharmaceutical technology. This paper aims to review the printing techniques used in a drug development process. The growing interest in 2D and 3D printing methods re...

Preparation of Polymeric and Composite Scaffolds by 3D Bioprinting.

Over the recent years, the advent of 3D bioprinting technology has marked a milestone in osteochondral tissue engineering (TE) research. Nowadays, the traditional used techniques for osteochondral regeneration remain to be inefficient since they cannot mimic the complexity of joint anatomy and tissue heterogeneity of articular cartilage. These limitations seem to be solved with the use of 3D bioprinting which can reproduce the anisotropic extracellular matrix (ECM) and heterogeneity of this tissue. In this ...

Genome Writing: Current Progress and Related Applications.

The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we sum...

Updated Follow-Up of a Tolerance Protocol in HLA-identical Renal Transplant Pairs Given Donor Hematopoietic Stem Cells.

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9 ½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 & 8 ½ years post-operatively. There has been continuing elevate...

Gas mixture for deep-UV plasma emission in a hollow-core photonic crystal fiber.

We report on the first deep-ultraviolet/ultraviolet (DUV/UV) emission using a highly compact microwave-driven plasma-core photonic crystal fiber. The latter consists of a few centimeter long micro-plasma column of a gas mixture in the core of Kagome hollow-core photonic crystal fiber. The plasma is generated by nonintrusively exciting a ternary gas mixture of argon, nitrogen, and oxygen (Ar/N2/O2) with a microwave resonator. Several spectral lines in the wavelength range of 200-450 nm were produced, guided...

The pipe model theory half a century on: a review.

More than a half century ago, Shinozaki et al. (Shinozaki K, Yoda K, Hozumi K, Kira T. 1964b. A quantitative analysis of plant form - the pipe model theory. II. Further evidence of the theory and its application in forest ecology. Japanese Journal of Ecology14: 133-139) proposed an elegant conceptual framework, the pipe model theory (PMT), to interpret the observed linear relationship between the amount of stem tissue and corresponding supported leaves. The PMT brought a satisfactory answer to two vividly d...

ICF and the Term "Substantial Disability" in the German Bundesteilhabegesetz (BTHG).

The new law, called "Bundesteilhabegesetz" was rapidly approved by the German legislative institutions in December 2016. It was supposed to be a milestone demonstrating the change from paternalistic care to the right of autonomous participation in all parts of social life. This new law sought to offer new ways, but actually there remains a big space for interpretations in the implementation. The law proposal wanted to claim 5 from the nine areas of life from the ICF. That was not accepted. Until December 20...

Urban-rural difference in satisfaction with primary healthcare services in Ghana.

Understanding regional variation in patient satisfaction about healthcare systems (PHCs) on the quality of services provided is instrumental to improving quality and developing a patient-centered healthcare system by making it more responsive especially to the cultural aspects of health demands of a population. Reaching to the innovative National Health Insurance Scheme (NHIS) in Ghana, surpassing several reforms in healthcare financing has been a milestone. However, the focus of NHIS is on the demand side ...

Mesoscopic Transport in Electrostatically Defined Spin-Full Channels in Quantum Hall Ferromagnets.

In this work, we use electrostatic control of quantum Hall ferromagnetic transitions in CdMnTe quantum wells to study electron transport through individual domain walls (DWs) induced at a specific location. These DWs are formed due to the hybridization of two counterpropagating edge states with opposite spin polarization. Conduction through DWs is found to be symmetric under magnetic field direction reversal, consistent with the helical nature of these DWs. We observe that long domain walls are in the insul...

Somatostatin Receptor 2-Targeting Compounds.

The molecular imaging and treatment of neuroendocrine tumors (NETs) with radiolabeled somatostatin analogs represent a milestone in the development of theranostic compounds. Whole-body scintigraphy with (111)In-pentetreotide has revolutionized the diagnosis and staging of NETs and the evaluation of treatment outcomes. At present, diagnostic accuracy with positron-emitting radionuclides is greater than 90%. Peptide receptor radionuclide therapy (PRRT) has become a well-accepted treatment for patients with we...

Visuo-spatial abilities are key for young children's verbal number skills.

Children's development of verbal number skills (i.e., counting abilities and knowledge of the number names) presents a milestone in mathematical development. Different factors such as visuo-spatial and verbal abilities have been discussed as contributing to the development of these foundational skills. To understand the cognitive nature of verbal number skills in young children, the current study assessed the relation of preschoolers' verbal and visuo-spatial abilities to their verbal number skills. In tota...

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