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PubMed Journals Articles About "Mupirocin Calcium Mupirocin Calcium Vehicle Secondarily Infected Traumatic" RSS

03:47 EST 15th December 2019 | BioPortfolio

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Showing "Mupirocin Calcium Mupirocin Calcium Vehicle Secondarily Infected Traumatic" PubMed Articles 1–25 of 6,100+

The Effect of Subinhibitory Concentrations of -Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Strains.

The aim of this study was to evaluate the effect of subinhibitory concentrations of -anethole on antibacterial and antibiofilm properties of mupirocin against mupirocin-resistant strains. Following parameters were examined: isolates susceptibility to antibiotics, minimum inhibitory concentration (MIC) of -anethole, antibacterial activity of mupirocin/-anethole combination, detection of gene, genotypic relativity of isolates using pulsed-field gel electrophoresis method, and the influence of mupirocin/-an...


Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections.

Staphylococcus aureus is a major cause of severe invasive infections. The increasing incidence of infections caused by antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA), calls for exploration of new approaches to treat these infections. Mupirocin is an antibiotic with a unique mode of action that is active against MRSA, but its clinical use is restricted to topical administration because of its limited plasma stability and rapid degradation to inactive metabolites. Mupirocin was id...

Mupirocin Resistance in Staphylococcus aureus: A Systematic Review and Meta-Analysis.

Staphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections which associate with high morbidity and mortality rates. Mupirocin has been increasingly used for treatment of S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) infections. The aim of the present study, was to determine the precise prevalence of Mupirocin Resistant S. aureus (MuRSA), Mupirocin Resistant MRSA (MuRMRSA), High Level MuRSA (HLMuRSA) and High Level MuRMRSA (HLMuRMR...


Clinical efficacy of dialkylcarbamoylchloride-coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa.

Dialkylcarbamoylchloride (DACC)-coated cotton acetate dressing works directly through hydrophobic interaction to reduce the number of bacteria without the risk of resistance. It is easy to use and therefore expected to improve patient's compliance. This study aimed to assess the clinical efficacy of DACC-coated cotton acetate dressing compared to combination of normal saline dressing and 2% mupirocin ointment. A single-blind controlled trial was conducted and included 14 infected EB wounds which were divide...

Development, characterization and pharmacokinetics of mupirocin-loaded nanostructured lipid carriers (NLCs) for intravascular administration.

Mupirocin is a promising broad-spectrum antibiotic that is effective in treating MRSA infections. However, due to its rapid elimination and hydrolysis following injection and high protein binding, current therapeutic use is limited to topical administration. Nanotechnology-driven innovations provide hope for patients and practitioners in overcoming the problem of drug degradation by encapsulation. The objective of this research is to develop and characterize Mupirocin-Loaded Nanostructured Lipid Carriers (M...

Are calcium oxalate crystals a dynamic calcium store in plants?

Calcium oxalate (CaOx) crystals occur as intravacuolar deposits in most angiosperm species. Different functions have been attributed to these crystals, some of which are very speculative, until now. Calcium regulation and homeostasis seems to be the most widespread function of CaOx crystals. Being rich in calcium, these crystals constitute a reserve of calcium for plants. However, despite being bioavailable, this reserve is functional in just a few situations due to the low mobility of calcium for phloem tr...

Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw

Staphylococcus aureus is a microorganism, which is able to colonize the human body without any pathogenic effect, but it also can cause life-threatening infections (opportunistic pathogen). Asymptomatic colonization with both methicillin resistant (MRSA) and methicillin susceptible (MSSA) S.aureus strains state is an important predisposing factor for infections. The risk of infection for carriers of MSSA is even three-times higher than for non-colonized people, and in the case of MRSA it is even four-times ...

Effects of pH and the plasma or serum concentrations of total calcium, chloride, magnesium, l-lactate, and albumin on the plasma ionized calcium concentration in calves.

The plasma ionized calcium concentration (cCa ) represents the biologically active form of calcium and is the preferred method for evaluating calcium status in animals. Different pH-corrective equations have been developed for human plasma, but the validity of the equations for bovine plasma is unknown.

Development and validation of a multivariate predictive model to estimate serum ionized calcium concentration from serum biochemical profile results in cats.

Measurement of serum ionized calcium is not always available in practice. Total calcium (tCa) might not be reliable for determination of calcium status in cats.

Corrected calcium versus ionized calcium measurements for identifying hypercalcemia in patients with multiple myeloma.

Dysregulated bone turnover is an important clinical manifestation of multiple myeloma (MM), and 30% of patients present with hypercalcemia. Serum calcium levels are routinely monitored using total calcium measurements corrected for albumin. However, myeloma-related paraproteins may bind calcium, confounding these measurements.

Microcalcifications, calcium-sensing receptor, and cancer.

Calcium stones and calculi are observed in numerous human tissues. They are the result of deposition of calcium salts and are due to high local calcium concentrations. Prostatic calculi are usually classified as endogenous or extrinsic stones. Endogenous stones are commonly caused by obstruction of the prostatic ducts around an enlarged prostate resulting from benign prostatic hyperplasia or from chronic inflammation. The latter occurs mainly around the urethra and is generally caused by reflux of urine int...

The regulatory roles of calcium channels in tumors.

Calcium (Ca) and its relevant transmembrane and intracellular calcium channels were previously thought to be chiefly associated with the regulation of cardiovascular and neuronal systems. Nowadays, an increasing evidence shows those calcium channels are also responsible for tumorigenesis and progression. However, the general underlying mechanisms and the involving signaling transduction pathways still remain unclear. Therefore in this mini-review, we are mainly focusing on the linkage between calcium channe...

Maltobionic acid enhances intestinal absorption of calcium and magnesium in rats.

In Experiment 1, the effects of calcium maltobionate (MBCa) on calcium and magnesium absorption were examined using male rats. Four diets were designed in which 25%, 50%, and 100% of calcium carbonate (CaCO, Control) were substituted with MBCa and were designated as MBCa-25, MBCa-50, and MBCa-100, respectively. The cecal concentration of short-chain fatty acids was significantly higher in groups MBCa-50 and MBCa-100; however, pH of cecal contents did not significantly differ among the groups. Retention rate...

Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro.

Calcium is the key macromineral having a role in skeletal structure and function, muscle contraction, and neurotransmission. Bone remodeling is maintained through a constant balance between calcium resorption and deposition. Calcium deficiency is resolved through calcium supplementation, and among the supplements, water-soluble organic molecules attracted great pharmaceutical interest. Calcium glucoheptonate is a highly water-soluble organic calcium salt having clinical use; however, detailed investigations...

A Stable Calcium Aluminyl.

Reaction of a seven-membered cyclic aluminyl anion with a b-diketiminato calcium tetraphenylborate provides facile access to a stable, but highly reactive, calcium aluminyl.

Mechanism underlying N-(3-oxo-dodecanoyl)-L-homoserine lactone mediated intracellular calcium mobilization in human platelets.

Acyl-homoserine lactones (AHLs), are the key autoinducer molecules that mediate Pseudomonas aeruginosa associated quorum sensing. P. aeruginosa produces two types of AHLs; N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C HSL) and N-butyryl-L-homoserine lactone (C4 HSL). AHLs are not only regulating the virulence gene of bacteria but also influence the host cell functions by interkingdom signaling. In this study, we explored the mechanism of AHLs induced calcium mobilization in human platelets. We found tha...

Bioaccessibility study of calcium and vitamin D co-microencapsulated in water-in-oil-in-water double emulsions.

Calcium and vitamin D were co-encapsulated in three types of water-in-oil-in-water (W/O/W) double emulsions stabilized with biopolymers: gum arabic, sodium alginate (Alg) and chitosan (Ch). Three calcium salts with different solubility were used: calcium carbonate (CaC), tricalcium phosphate (CaP) and calcium gluconate (CaG). In order to study the bioavailability of calcium and vitamin D, the W/O/W double emulsions were subjected to digestion in simulated conditions using in vitro gastrointestinal models. T...

Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells.

To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors.

STIM calcium sensing and conformational change.

The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. STIM1 is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has...

Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model.

Local antibiotic delivery systems with differing chemical and mechanical properties have been developed to assist in the management of osteomyelitis. We investigated the bone conductive and resorptive capabilities of a calcium phosphate-calcium sulfate (CaP/CaS) composite compared with commercially available polymethylmethacrylate (PMMA). In addition, we compared the in vivo preventative and treatment efficacies of both biomaterials in a proven osteomyelitis model.

The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.

Mutations in connexin50 (Cx50) and connexin46 (Cx46) cause cataracts. Because the expression of Cx46fs380 leads to decreased gap junctional coupling and formation of calcium precipitates, we studied Cx50D47A lenses to test whether Cx50 mutants also cause cataracts due to calcium precipitation.

Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels.

Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state when neurons were intracellularly dialyzed with EGTA but attenuated the neuronal activity when BAPTA was used as an intracellular calcium buffer. This suggests that neuronal excitability can be modulated by zinc, depending on the internal calcium buffering capacity. In this study, we elucidated...

Calcium-binding casein phosphopeptides-loaded chitosan oligosaccharides core-shell microparticles for controlled calcium delivery: fabrication, characterization, and in vivo release studies.

Core-shell microparticles based on food-grade biopolymers are of particular interest for biological components delivery owing to their unique controlled release property. Here, we introduce a method to fabricate calcium-binding casein phosphopeptides (CPP)-loaded core-shell microparticles for oral calcium delivery, based on ionic gelation interactions between chitosan oligosaccharides (COS) and tripolyphosphate (TPP). The fabrication method, textural properties, calcium binding capacity, pH-dependent stabil...

Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon.

Women from low and middle income countries are generally more likely to have sub-optimal calcium intake. The objective of this study was to assess serum calcium disorders and correlates in late pregnancy.

Two-Step Hydrothermal Preparation of Carbon Dots for Calcium Ion Detection.

It is well known that calcium ion is essential for maintaining life activities in living organisms, and it is of great significance to detect the intracellular calcium concentration. For the detection of calcium ions, we developed a new type of fluorescent carbon dots, whose surface was modified by EGTA through a secondary hydrothermal method. This is a simple and convenient chemical preparation method because all reactions are carried out in the same autoclave, and the final product is directly the EGTA-mo...


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