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PubMed Journals Articles About "NAVIN FLUORINE" RSS

18:31 EDT 18th July 2018 | BioPortfolio

NAVIN FLUORINE PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest NAVIN FLUORINE articles that have been published worldwide.

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Showing "NAVIN FLUORINE" PubMed Articles 1–25 of 168

Supercritical temperature synthesis of fluorine-doped VO2(M) nanoparticle with improved thermochromic property.

Fluorine-doped VOsub>2</sub>(M) nanoparticles have been successfully synthesized using the hydrothermal method at a supercritical temperature of 490°C. The pristine VO<sub>2</sub>(M) has the critical phase transformation temperature of 64°C. The morphology and homogeneity of the monoclinic structure VO<sub>2</sub>(M) were adopted by the fluorine-doped system. The crystallinity and particle size were reduced the bigger the concentration of fluorine doping. The obtained part...


Effects of fluorine on crops, soil exoenzyme activities, and earthworms in terrestrial ecosystems.

Fluorine can flow into the environment after leakage or spill accidents and these excessive amounts can cause adverse effects on terrestrial ecosystems. Using three media (filter paper, soil, and filter-paper-on-soil), we investigated the toxic effects of fluorine on the germination and growth of crops (barley, mung bean, sorghum, and wheat), on the activities of soil exoenzymes (acid phosphatase, arylsulfatase, fluorescein diacetate hydrolase, and urease) and on the survival, abnormality, and cytotoxicity ...

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination.

Activation of carbon-fluorine (C-F) bonds is an important topic in synthetic organic chemistry recently. Among the methods for C-F bond cleavage, metal mediated and catalyzed β- or α-fluorine elimination proceeds under mild conditions compared with oxidative addition of C-F bond. The β- or α-fluorine elimination is initiated from organometallic intermediates having fluorine substituents on carbon atoms β or α to metal centers, respectively. Transformations via these elimination processes (C-F bond cle...


Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

The electronic properties and relatively small size of fluorine endow it with considerable versatility as a bioisostere and it has found application as a substitute for lone pairs of electrons, the hydrogen atom, and the methyl group while also acting as a functional mimetic of the carbonyl, carbinol, and nitrile moieties. In this context, fluorine substitution can influence the potency, conformation, metabolism, membrane permeability, and P-gp recognition of a molecule and temper inhibition of the hERG cha...

Fluorine walk: The impact of fluorine in quinolone amides on their activity against African sleeping sickness.

Human African Trypanosomiasis, also known as African sleeping sickness, is caused by the parasitic protozoa of the genus Trypanosoma. If there is no pharmacological intervention, the parasites can cross the blood-brain barrier (BBB), inevitably leading to death of the patients. Previous investigation identified the quinolone amide GHQ168 as a promising lead compound having a nanomolar activity against T. b. brucei. Here, the role of a fluorine substitution at different positions was investigated in regard ...

Comparison of SF₆ and CF₄ Plasma Treatment for Surface Hydrophobization of PET Polymer.

The fluorination of the polymer polyethylene terephthalate in plasma created from SF₆ or CF₄ gas at various pressures was investigated. The surface was analysed by X-ray photoelectron spectroscopy and water contact angle measurements, whereas the plasma was characterized by optical emission spectroscopy. The extent of the polymer surface fluorination was dependent on the pressure. Up to a threshold pressure, the amount of fluorine on the polymer surface and the surface hydrophobicity were similar, which...

Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates.

Phosphodiesterase 10A (PDE10A) is a member of the PDE enzyme family that degrades cyclic adenosine and guanosine monophosphates (cAMP and cGMP). Based on the successful development of [11C]T-773 as PDE10A positron emission tomography (PET) radioligand, in this study our aim was to develop and evaluate fluorine-18 analogs of [11C]T-773.

Molecular Dynamics Pinpoint the Global Fluorine Effect in Balanoids Binding to PKCε and PKA.

(-)-Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with little selectivity. While PKA is known as a tumour promoter, PKC isozymes can be tumour promoters or suppressors. In particular, PKCε is frequently involved in tumorigenesis and a potential target for anticancer drugs. We recently reported that stereospecific fluorination of balanol yielded a balanoid with enhanced selectivity for PKCε over other PKC isozymes and PKA, although the global ...

New insights into the influence of Monofluorination on Dimyristoylphosphatidylcholine membrane properties: A solid-state NMR study.

Solid-state 19F NMR spectroscopy is a method of choice to study the interactions between lipid membranes and other molecules such as peptides, proteins or drugs. Numerous fluorine-labeled NMR probes have been developed over the last few years, especially fluorine-labeled peptides. In order to develop a new kind of NMR reporter molecule and a complementary approach to fluorine-labeling of peptides, we synthesized six monofluorinated derivatives of the lipid dimyristoylphosphatidylcholine (F-DMPC), with the f...

Radical Carbofluorination of Unactivated Alkenes with Fluoride Ion.

The copper-assisted radical carbofluorination of unactivated alkenes with fluoride ion is described. With [Cu(L3)F2]H2O (L3 = 4,4'-di(methoxycarbonyl)-2,2'-bipyridine) as the fluorine source and [Ag(DMPhen)(MeCN)]BF4 (DMPhen = 2,9-dimethyl-1,10-phenanthroline) as the chloride scavenger, the reaction of unactivated alkenes with CCl4 in acetonitrile provided the corresponding carbofluorination products in satisfactory yields. The protocol exhibited a wide functional group compatibility and broad substrate sco...

Effect of Fluorinated Ligand on Structural, Electronic and DNA-binding Properties of Copper Paddlewheel Complex: Synthesis, Structure and Properties.

This paper presents synthesis, structural description and properties of a binuclear paddlewheel copper(II) carboxylate complex with formula [(py)Cu(μ-L)4Cu(py)], where py = pyridine and L = 4-fluorophenylacetate. Structural characteristics, electronic absorption and DNA-binding properties of the synthesized complex have been compared to those of the non-fluorinated analogues (where F is replaced by H, -CH3 and -OCH3) already reported and the modifications successfully ascribed to fluorine. The complex exhi...

Spectroscopic Characterization of a C-F-C+ Fluoronium Ion in Solution.

We report the first spectroscopic evidence for a [C-F-C]+ fluoronium ion in solution. Extensive NMR studies (19F, 1H, 13C) characterize a symmetrical cage-like species in which fluorine exhibits substantial covalent bonding to each of the two carbon atoms involved in the three-center interaction. Experimental NMR data comport well with calculated values to lend credence to the structural assignment. As the culminating experiment, the Saunders isotopic perturbation test definitively confirms a symmetrical st...

Oligometastatic recurrent prostate cancer detects by fluorine-18-choline positron emission tomography/computed tomography in patients with prostate-specific antigen levels of up to 5 ng/ml.

The aim of this study was to assess the ability of fluorine-18-fluorocholine (F-FCH) PET/computed tomography (CT) to detect oligometastatic disease (OMD) in patients with early recurrence of prostate cancer (PC) [prostate-specific antigen (PSA)≤5 ng/ml].

Fluorine MR Imaging Monitoring of Tumor Inflammation after High-Intensity Focused Ultrasound Ablation.

Purpose To investigate whether high-intensity focused ultrasound (HIFU)-induced macrophage infiltration could be longitudinally monitored with fluorine 19 (19F) magnetic resonance (MR) imaging in a quantitative manner. Materials and Methods BALB/c mice were subcutaneously inoculated with 4T1 cells and were separated into three groups: untreated mice (control, n = 9), HIFU-treated mice (HIFU, n = 9), and HIFU- and clodronate-treated mice (HIFU+Clod, n = 9). Immediately after HIFU treatment, all mice were int...

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.

A novel series of tubulin polymerization inhibitors, based on fluorinated derivatives of isocombretastatin A-4 was synthesized with the goal of evaluating the effect of these compounds on the proliferative activity. The introduction of fluorine atom was performed on the phenyl ring or at the linker between the two aromatic rings. The modification of isoCA-4 by introduction of difluoromethoxy group at the para-position (3i) and substitution of the two protons of the linker by two fluorine atoms (3m), produce...

Taking advantage of hydrophobic fluorine interactions for self-assembled nanoclusters of quantum dots as delivery platform for enzymes.

Self-assembly of nanoparticles provides unique opportunities as nanoplatforms for controlled delivery. By exploiting the important role of non-covalent hydrophobic interactions in the engineering of stable assemblies, nanoclusters were formed by self-assembly of fluorinated quantum dots in aqueous medium through fluorine-fluorine interactions. These nanoclusters were able to encapsulate different enzymes (laccase and α-galactosidase) obtaining encapsulation efficiencies ≥ 74 %. Importantly, the encapsula...

Optimal timing of fluorine-18-fluoromisonidazole positron emission tomography/computed tomography for assessment of tumor hypoxia in patients with head and neck squamous cell carcinoma.

The aim of this study was to identify the optimal timing of fluorine-18-fluoromisonidazole (F-MISO) PET/CT imaging to assess hypoxia in patients with head and neck squamous cell carcinoma.

Over 14% Efficiency in Polymer Solar Cells Enabled by a Chlorinated Polymer Donor.

Fluorine-contained polymers, which have been widely used in highly efficient polymer solar cells (PSCs), are rather costly due to their complicated synthesis and low yields in the preparation of components. Here, the feasibility of replacing the critical fluorine substituents in high-performance photovoltaic polymer donors with chlorine is demonstrated, and two polymeric donors, PBDB-T-2F and PBDB-T-2Cl, are synthesized and compared in parallel. The synthesis of PBDB-T-2Cl is much simpler than that of PBDB-...

Rational design of low cost and high energy lithium batteries through tailored fluorine-free electrolyte and nanostructured sulfur/carbon composite.

We report a new lithium/sulfur cell concept based on an optimized fluorine-free catholyte solution and a high loading nanostructured carbon/sulfur composite cathode. The Li2S8 present in the electrolyte ensures both buffering against active material dissolution and Li+ conduction. The high sulfur loading is obtained by confining elemental sulfur (~80%) in the mesopores of a highly ordered CMK3 carbon. With this concept we demonstrate stabilization of high energy density and excellent cycling performance ove...

Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan.

Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET).

Photoelectrocatalytic degradation of atrazine by boron-fluorine co-doped TiO nanotube arrays.

Atrazine, one of the most widespread herbicides in the world, is considered as an environmental estrogen and has potential carcinogenicity. In this study, atrazine was degraded on boron-fluorine co-doped TiO nanotube arrays (B, F-TiO NTAs), which had similar morphology with the pristine TiO NTAs. The structure and morphology of TiO nanotube samples were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and UV-visible diffuse reflectance spectroscopy (DRS). It showed that the deco...

A novel UV-photolysis approach with acetone and isopropyl alcohol for the rapid determination of fluoride in organofluorine-containing drugs by spectrophotometry.

A UV photolysis decomposition (UVPD) method for the determination of fluoride in fluorine containing pharmaceuticals by spectrophotometry is reported. It is based on the use of high intensity UV-irradiation in the presence of a digesting solution comprising a mixture of acetone and isopropanol. For the optimization of the UVPD procedure, three bulk drugs (levofloxacin, nebivolol and efavirenz) were chosen as representatives of three diverse compounds containing a single fluorine atom, two fluorine atoms, an...

Relationship of Water Content With Silicon and Fluorine Contents of Silicone-Hydrogel Contact Lens Materials.

The relationship between water (W) content and silicon (Si) content of silicone-hydrogel (SiHy) contact lens materials was inspected using identical methodologies, equipment, and operators for materials composing 16 types of commercially available SiHy contact lenses. Fluorine (F) content was included in the analysis for the three materials also containing a fluoropolymer. One type of lens consisted of a bulk SiHy material coated with thin layers of conventional hydrogel.

AgFeOF: A Fluorine-Rich Perovskite Oxyfluoride.

We synthesized a silver iron oxyfluoride AgFeOF by using a high-pressure reaction. Synchrotron X-ray and neutron diffraction, X-ray absorption, and Fe Mössbauer spectroscopy indicate that AgFeOF crystallizes in the ideal perovskite structure with iron in a trivalent state, although electron microscopy revealed weak super-reflections. A possible partial ordering in the FeOF octahedron is inferred from Mössbauer spectroscopy. The synthesis of the fluorine-rich sample offers an opportunity to study a composi...

One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging.

Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positron-emitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be p...


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