PubMed Journals Articles About "NRL972 Cirrhosis" RSS

13:48 EST 19th January 2020 | BioPortfolio

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Showing "NRL972 Cirrhosis" PubMed Articles 1–25 of 425

Complications of liver cirrhosis - pharmaceutical versus interventional therapy.

Liver cirrhosis is a major healthcare problem and is associated with an increased mortality due to the development of complications. Therefore, after diagnosis of liver cirrhosis, it is highly clinically relevant to evaluate the reason for liver cirrhosis and to assess the presence of complications in order to prevent progression of liver cirrhosis.

Etiology of cirrhosis in the young.

The etiology and incidence of cirrhosis in adults has been well studied, however there is scant data in younger patients. The aim of this study was to determine causes of cirrhosis in patients ≤40years old. In this multi-institutional retrospective study, pathology databases were searched for patients ≤40-year-old with a diagnosis of cirrhosis from 1995 to 2018. Clinical charts and pathology reports were reviewed to identify etiologies of cirrhosis in each case. The patients were divided into 4 age grou...

Relationship Between Diabetes Mellitus and Cirrhosis Risk in Chronic Hepatitis B Patients in Wuhan, China.

BACKGROUND The objective of our research was to assess the possible link between diabetes mellitus (DM) and liver cirrhosis in chronic hepatitis B (CHB) patients in Wuhan, China. MATERIAL AND METHODS Individuals with a diagnosis of both liver cirrhosis and chronic HBV infection (n=257), and CHB-only patients (n=514) were matched 1: 2 by age and sex. Demographic, lifestyle, laboratory, and clinical characteristics were reviewed. Univariate and the multiple logistic regression analysis were conducted to inves...

Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden: a population-based study.

Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared to cirrhosis of other etiologies, in Sweden. We used population-based medical registries to identify patients diagnosed with cirrhosis in the Scania region in southern Sweden between 2001 and 2010. Medical record...

Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis.

Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina.

The effect of cirrhosis on trauma outcomes: A systematic review and meta-analysis.

The negative effect of cirrhosis on mortality following traumatic injury has been quantified in multiple observational studies. However, to our knowledge, the information contained in these studies has never been synthesized. The aims of this study were: 1) to determine the magnitude of the effect of liver cirrhosis on mortality, morbidity and hospital course among trauma patients and 2) to analyze sources of study heterogeneity that may lead to differing estimates in the observed mortality rate among patie...

Sustained impact of nosocomial-acquired spontaneous bacterial peritonitis in different stages of decompensated liver cirrhosis.

Bacterial infections, in particular a spontaneous bacterial peritonitis (SBP), are a major threat in patients with liver cirrhosis. Recently, it has been shown that the impact on mortality might be underestimated by established risk-scores. Onset of infection was suggested to define a distinct stage of cirrhosis. However, it remains unclear whether all stages of decompensated cirrhosis are equally affected. Moreover, if there is such a distinct stage, it must be determined whether it is reversible after the...

Peculiarities of Cirrhosis due to Nonalcoholic Steatohepatitis (NASH).

The prevalence of cirrhosis due to nonalcoholic steatohepatitis (NASH) has increased 2.5-fold in the United States in the last decade. These patients pose new challenges to hepatologists given their older age and higher frequency of coexisting metabolic diseases such as obesity and diabetes compared with other etiologies of liver disease. Patients with NASH cirrhosis are at higher risk for renal and cardiovascular disease, and the presence of these extrahepatic comorbidities has a significant impact on outc...

Advances in the study of gastroesophageal varices with portal vein thrombosis in liver cirrhosis.

Portal vein thrombosis (PVT) is one of the serious complications in the decompensated stage of liver cirrhosis, which is often accompanied by the aggravation of liver cirrhosis and other complications and in severe cases; it may induce gastroesophageal variceal hemorrhage and endanger the lives of patients. Furthermore, the most common complication in decompensated stage of cirrhosis is history of gastroesophageal variceal hemorrhage and the formation of PVT that may be a risk factor to promote each other. ...

Anticoagulation in patients with cirrhosis and portal vein thrombosis: safety and beneficial effect on OLT free survival.

We read with interest the letter by Andrea Mancuso on clinical significance of portal vein thrombosis (PVT) in cirrhosis and potential utility of anticoagulation. In our prospective study, thrombocytopenia and previous decompensation of cirrhosis predicted PVT development in cirrhosis suggesting that severity of portal hypertension rather than liver failure plays a pathophysiologic role . This article is protected by copyright. All rights reserved.

Risk factors associated with hepatic osteopathy in HBV related cirrhosis measured by liver stiffness: An Observational study.

To investigate the differences in bone mineral density between patients with liver cirrhosis and healthy control, and to analyze the risk factors of hepatic osteoporosis in patients with HBV related liver cirrhosis.A total of 189 patients with liver cirrhosis and 207 health controls were enrolled. The bone mineral density of lumbar spine and femoral neck was examined by dual energy X-ray absorptiometry. -2.0

Specialized care improves outcomes for patients with cirrhosis who require general surgical operations.

General surgical operations on patients with cirrhosis have historically been associated with high morbidity and mortality rates. This study examines a contemporary series of patients with cirrhosis undergoing general surgical procedures.

Venous Thromboembolism in Patients with Liver Cirrhosis: Findings from the RIETE (Registro Informatizado de la Enfermedad TromboEmbolica) Registry.

Patients with cirrhosis are not only at an increased risk of bleeding but also at risk of venous thromboembolism (VTE). We sought to determine the clinical characteristics, management, and outcomes after VTE in patients with cirrhosis. We used the data from RIETE (Registro Informatizado de la Enfermedad TromboEmbolica), an international registry of patients with VTE, to compare the outcomes in patients with and without cirrhosis. Main outcomes included all-cause mortality, pulmonary embolism (PE)-related mo...

Nosocomial Infections Are Frequent and Negatively Impact Outcomes in Hospitalized Patients With Cirrhosis.

Nosocomial infections (NIs) can be a major cause of morbidity and mortality in cirrhosis. This study aims to define the determinants of NI development and its impact on 30-day outcomes among hospitalized patients with cirrhosis.

An Ordinal Model to Predict the Risk of Symptomatic Liver Failure in Patients with Cirrhosis undergoing Hepatectomy.

Selection criteria for hepatectomy in patients with cirrhosis are debatable. This study aimed at building prognostic models of symptomatic post-hepatectomy liver failure (PHLF) in patients with cirrhosis.

Laparoscopic Cholecystectomy Is Safe in Emergency General Surgery Patients with Cirrhosis.

Cirrhosis is associated with adverse outcomes after emergency general surgery (EGS). The objective of this study was to determine the safety of laparoscopic cholecystectomy (LC) in EGS patients with cirrhosis. We performed a two-year retrospective cohort analysis of adult patients who underwent LC for symptomatic gallstones. The primary outcome was the incidence of intraoperative complications. Of 796 patients, 59 (7.4%) were cirrhotic, with a median model for end-stage liver disease (MELD) score of 15 (IQR...

Setting ambitious targets for surveillance and treatment rates among patients with hepatitis C related cirrhosis impacts the cost-effectiveness of hepatocellular cancer surveillance and substantially increases life expectancy: A modeling study.

Hepatocelluar cancer (HCC) is the leading cause of death among people with hepatitis C virus (HCV)-related cirrhosis. Our aim was to determine the optimal surveillance frequency for patients with HCV-related compensated cirrhosis.

Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis.

Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirrhosis.

Validation of Knowledge Questionnaire for Patients With Liver Cirrhosis.

There is no validated questionnaire to assess disease knowledge and self-management in patients with liver cirrhosis. We developed and validated a cirrhosis knowledge questionnaire (CKQ).

The Delta-4 fibrosis score (D4FS): A novel fibrosis score in chronic hepatitis D.

Chronic Hepatitis D virus (HDV) infection results in the most severe form of viral hepatitis with a rapid progression to cirrhosis. However, non-invasive fibrosis tests that can accurately predict cirrhosis have not been adequately validated. We aimed to develop a clinically useful non-invasive score that can accurately detect cirrhosis.

Serum and urinary metabolomics and outcomes in cirrhosis.

Cirrhosis can alter several metabolic pathways. Metabolomics could prognosticate outcomes like hepatic encephalopathy (HE), transplant, hospitalization and death.

Descriptive Usability Study of CirrODS: Clinical Decision and Workflow Support Tool for Management of Patients With Cirrhosis.

There are gaps in delivering evidence-based care for patients with chronic liver disease and cirrhosis.

Advanced Practice Providers: Raising Our Defenses Against the Rising Tide of Cirrhosis.

The medical journey for patients with cirrhosis is complex and costly. In addition to the clinical complications related to hepatic dysfunction and portal hypertension, patients contend with extensive comorbidities, physical frailty, psychosocial factors, addictions, and the challenge of navigating through a web of often disconnected provider appointments and tests. Not surprisingly, patients with decompensated disease have high rates of rehospitalization with admission costs estimated at $25,000 and approx...

Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in child-pugh b cirrhosis.

Treatment allocation of patients with hepatocellular carcinoma (HCC) on Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed by small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis focusing on the surgical risks and survivals.

Palliative care in cirrhosis with decompensation.

Cirrhosis with decompensation has a poor prognosis, high symptom burden and causes carer stress. This pilot research in one tertiary hospital found that patients with cirrhosis with decompensation were infrequently referred to specialist palliative care. Despite this, they had a heavy symptom burden, high predicted mortality, frequent unplanned readmissions, long admissions and intensive care unit admissions. Few had adequate advance care planning.

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