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PubMed Journals Articles About "Naproxen" RSS

11:46 EST 6th December 2019 | BioPortfolio

Naproxen PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Naproxen articles that have been published worldwide.

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Showing "Naproxen" PubMed Articles 1–25 of 32

Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export.

Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA. Here, we show that naproxen is a potential broad, multi-mechanistic anti-influenza virus therapeutic, as it inhibits influenza B virus replication both in vivo and in vitro. The anti-influenza B virus activity of naproxen is more efficient than that of the commonly used neuraminidase inhibitor oseltamivir in mice. Furtherm...


Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.

BACKGROUND Curcumin is an antioxidant that reduces inflammation and pain. This study aimed to assess the effect of pretreatment with naproxen and liposomal curcumin compared with naproxen and curcumin solution on oxidative stress parameters and pain in a rat model of migraine. MATERIAL AND METHODS Sixty-three male Wistar rats included a control group (n=9) and a rat model of migraine (n=54) induced by intraperitoneal injection of nitroglycerin (1 mg/0.1 kg). The rat model group was divided into an untreated...

Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen.

The extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC) of naproxen in H. magnipapillata were 51.999 mg/L, 44.935 mg/L, and 42.500 mg/L after exposure for 24, 48, and 72 h, respectively. Morphological obs...


Preparation of poly(4-vinylpyridine)-functionalized magnetic Al-MOF for the removal of naproxen from aqueous solution.

In this work, a novel poly(4-vinylpyridine)-functionalized magnetic Al-MOF (Al-MOF-FeO@P4VP) was synthesized successfully as an adsorbent for the adsorption of naproxen from aqueous solution. The resulting adsorbent was characterized with scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), BET surface area and X-ray photoelectron spectroscopy (XPS). Al-MOF-FeO@P4VP had high s...

Biological removal of pharmaceuticals by Navicula sp. and biotransformation of bezafibrate.

Pharmaceutically active compounds are of great concern due to their detection frequency in the environment and the unexpected risks. In this study, the simultaneous removal of mixed pharmaceuticals by microalgae was explored using a typical freshwater diatom Navicula sp. Results showed that Navicula sp. could efficiently remove atenolol, carbamazepine, ibuprofen and naproxen with the efficiencies of >90% after 21 d of exposure. As compared to the removal efficiencies of each pharmaceutical in the individu...

Evaluating the enantiospecific differences of non-steroidal anti-inflammatory drugs (NSAIDs) using an ecotoxicity bioassay test battery.

Wastewater treatment plants are a major pathway for pharmaceuticals to the aquatic environment. Many pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs), are chiral chemicals and the biological activity of their enantiomers can differ. Few studies have assessed the effects of different NSAID enantiomers on non-target organisms. However, this information is important for environmental risk assessment to ensure that the effects of more potent enantiomers are not overlooked. In the curren...

Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen ?

Spray freeze drying (SFD) was used to prepare re-dispersible powders of crystalline, pure-drug nanodispersions of naproxen in lactose and stabilized with hydroxypropyl cellulose. The particle size of the rehydrated powders was determined using static light scattering/Mie analysis. The nanoparticles present in the SFD powders were aggregated but could be dispersed on re-dispersion with water and stirring either with or without additional ultrasonic treatment. The disaggregation of the SFD nanoparticles was s...

Anti-inflammatory surface coatings based on polyelectrolyte multilayers of heparin and polycationic nanoparticles of naproxen-bearing polymeric drugs.

Immune response to biomaterials can produce chronic inflammation and fibrosis leading to implant failure, which is related to surface properties of the biomaterials. This work describes the preparation and characterization of polyelectrolyte multilayer (PEM) coatings that combine the anti-inflammatory activity of heparin as polyanion with the potential release of Naproxen a nonsteroidal anti-inflammatory drug from polymeric nanoparticles (NP) with cationic surface charge. The polyelectrolyte multilayers wer...

Removal of trace naproxen from aqueous solution using a laboratory-scale reactive flow-through membrane electrode.

The kinetics and mechanisms of naproxen (NPX) degradation with the concentration of 20-200 μg/L were investigated by using reactive flow-through membrane anode. The electrochemical degradation of NPX followed pseudo-first-order reaction kinetics. The kinetic rate constant (k) of 0.649 min and energy consumption (E) of 0.744 Wh/L were found under optimal conditions with the initial NPX concentration of 50 μg/L. Higher current density benefited •OH production and NPX degradation. Faster rotational s...

Efficient degradation of refractory organic contaminants by zero-valent copper/hydroxylamine/peroxymonosulfate process.

Degradation of naproxen, bisphenol S and ibuprofen in a hydroxylamine enhanced zero-valent copper (Cu) catalyzed peroxymonosulfate system was investigated for the first time. We found that hydroxylamine addition accelerated the reduction of Cu to Cu as well as the corrosion of Cu, and environmental friendly gas nitrogen was the main product of hydroxylamine. Additionally, hydroxyl radical and sulfate radical were identified to be the dominant reaction species by competitive experiments. The degradation of n...

Spectroscopic and quantum computational study on naproxen sodium.

The spectroscopic (FT-IR, FT-Raman, NMR), electronic (UV--Vis.), structural and thermodynamical properties of an anti-inflammatory analgesic called Naproxen Sodium, (s)-6-methoxy-α-methyl-2-naphthaleneacetic acid sodium salt are submitted by using both experimental techniques and theoretical methods as quantum chemical calculations in this work. The equilibrium geometry and vibrational spectra are calculated by using DFT (B3LYP) with 6-311++G (d,p) basis set using GAUSSIAN 09. The vibrational wavenumbers a...

Activation of peroxymonosulfate system by copper-based catalyst for degradation of naproxen: Mechanisms and pathways.

Organic degradation by zero-valent metal (ZVM)-activated peroxymonosulfate (PMS) systems has drawn great attention in water treatment. Among various types of ZVM, zero-valent copper (ZVC) showed greatest activating capacity. However, the disadvantages of the released Cu limit the practical utilization of ZVC. In this study, the activation capacity of four normal-sized copper catalysts, namely, copper sheet, graphene-copper sheet, copper foam, and graphene-copper foam, for PMS was investigated using Naproxen...

Long-term treatment with naproxen changes the chemical coding of the porcine intramural duodenum neurons.

Due to numerous therapeutic applications and high availability, non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs worldwide. However, long-term use of these drugs can lead to damage to the gastrointestinal mucosa. The enteric nervous system (ENS), which is part of the autonomic nervous system, controls most aspects of gastrointestinal activity. Enteric neurons are characterized by considerable chemical plasticity and the appearance of a pathological factor results in a change in ...

Distribution and ecological risk of pharmaceuticals in surface water of the Yeongsan river, Republic of Korea.

This study examined the distribution of pharmaceuticals in Yeongsan River and at point sources (PSs) in the associated water system, and performed a risk assessment based on our findings. The samples included effluents collected from three sewage treatment plants (PS1, PS2, and PS3) and two industrial complexes (PS4 and PS5) as well as surface water collected from seven mainstreams and 11 tributaries of the river. The target pharmaceuticals were acetylsalicylic acid, carbamazepine, clarithromycin, naproxen,...

Occurrence and Fate of Micropollutants in Private Wastewater Treatment Facility (WTF) and Their Impact on Receiving Water.

This study investigated the occurrence and removals of micropollutants in the sewage treatment tank (STT) which is a typical private wastewater treatment facility used in the rural communities in Korea, and their impact on receiving water. STTs were selected in eight provinces to examine the regional difference in the composition of micropollutant occurrence. We measured ten selected micropollutants in influents and effluents of STTs, as well as upstream and downstream of its receiving surface water. The do...

Occurrence, Concentrations, and Risks of Pharmaceutical Compounds in Private Wells in Central Pennsylvania.

Over-the-counter and prescription medications are routinely present at detectable levels in surface and groundwater bodies. The presence of these emerging contaminants has raised both environmental and public health concerns, particularly when the water is used for drinking either directly or with additional treatment. However, the frequency of occurrence, range of concentrations, and potential human health risks are not well understood, especially for groundwater supplies. Private wells are often not teste...

Biocompatibility, In Vitro Anti-proliferative and In Silico EGFR/VEGFR2 Studies of Heteroleptic Metal(II) Complexes of Thiosemicarbazones and Naproxen.

Eight heteroleptic nickel(II) and copper(II) complexes of the type [M(L14)(nap)2] (18), where L14 = 2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide, nap = naproxen and M = Ni(II) or Cu(II) have been synthesized and characterized. UV-Vis and EPR spectral studies showed distorted octahedral geometry around metal(II) ions. Cyclic voltammogram of complexes (1 displayed irreversible one electron transfer process in the cathodic region (Epc = 0.66 to 1.43 V), and nickel(II) co...

Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy.

A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared t...

Occurrence and ecological risk assessment of selected antibiotics in the freshwater lakes along the middle and lower reaches of Yangtze River Basin.

Lakes are regarded as copious antibiotic reservoirs because the antibiotics discharged by human activities mostly end up in lakes and further threaten the aqueous ecosystem. Antibiotic contamination in lakes is mostly attributed to wastewater treatment plant effluents, which change the water quality and pose ecological risks. This study investigated the concentration of 10 selected antibiotics in 17 lakes along the middle and lower reaches of the Yangtze River Basin. The correlation between antibiotics and ...

Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. Case example: Naproxen.

Physiologically-based population pharmacokinetic modeling (popPBPK) coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can serve as a powerful tool to establish virtual bioequivalence and set clinically relevant specifications. One of several applications of popPBPK modeling is in the emerging field of virtual bioequivalence (VBE), where it can be used to streamline drug development by implementing model-informed formulation design and to inform regulatory decision-making e...

Low-Glycemic-Index Diet Relieving Migraine but Inducing Muscle Cramps.

Low-glycemic-index diet (LGID) has been shown to exhibit a beneficial effect in patients with epilepsy, exercise-induced dyskinesia, writer's cramp, migraine, and in myopathic mice. A 57-year-old female with classical migraine with and without aura since 14 years of age and a frequency of 8 to 12 attacks per month experienced some relief using a nasal spray of zolmitriptan since 10 years. Occasionally, she developed a status migrainosus lasting up to 5 days. At the age of 57 years, she started an LGID and r...

In silico and in vitro study of the inhibitory effect of anti-inflammatory drug betamethasone on two lipases.

•Background: For the first time, the anti-inflammatory drugs: celecoxib, aspirin DL-lysine, niflumic acid, naproxen sodium, ibuprofen, and betamethasone are investigated for their inhibition activity against lipase. • Objective: This work aims to demonstrate the inhibitory effect in vitro & in silico of six anti-inflammatory drugs on the enzymatic activity of two lipases. • Method: In vitro study using p-nitrophenyllaurate as lipase substrate is used to determine inhibition potency. Molecular Docking ...

Hydrolytic stability of selected pharmaceuticals and their transformation products.

The fact that pharmaceuticals are present in the environment has been proven in numerous publications. Nevertheless, their transformation products (mainly metabolites) are detected significantly less often, mainly because they are not included in the detecting methods, even though many of them are excreted from organisms at high rates and may be biologically active or have other properties that make them a potential threat to the environment. One of the most common processes that occur in the aqueous enviro...

Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide (COS) and Hydrogen Sulfide (H2S) Independently in Thiol-Promoted Pathways.

Hydrogen sulfide (H2S) is an important signaling molecule that provides protective activities in a variety of physiological and pathological processes. Among the different types of H2S donor compounds, thioamides have attracted attention due to prior conjugation to non-steroidal anti-inflammatory drugs (NSAIDs) to access H2S-NSAID hybrids with significantly-reduced tox-icity, but the mechanism of H2S release from thioamides remains unclear. Herein, we reported the synthesis and evaluation of a class of thio...

Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach.

Pharmaceuticals and personal care products (PPCPs), the pollutants of emerging concerns, present potential risks to the ecological environment. This study focused on the prioritization of widely used selected PPCPs belonging to two categories:personal care products (PCPs) and non-steroidal anti-inflammatory drugs (NSAIDs). We predicted the toxicogenetic endpoints of PPCPs and then confirmed them using experimental approaches. Our results revealed a significant similarity in the findings obtained through bot...


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