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PubMed Journals Articles About "Neuroimmune Interactions Nervous Immune Systems Influence Each Other" RSS

06:44 EDT 16th September 2019 | BioPortfolio

Neuroimmune Interactions Nervous Immune Systems Influence Each Other PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Neuroimmune Interactions Nervous Immune Systems Influence Each Other articles that have been published worldwide.

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Showing "Neuroimmune interactions nervous immune systems influence each other" PubMed Articles 1–25 of 27,000+

Neuroimmune interactions: how the nervous and immune systems influence each other.

In recent years, researchers worldwide have expanded our understanding of how, and the degree to which, the immune system interacts with the nervous system, and vice versa. In this issue of Clinical & Experimental Immunology, we are pleased to present our new Review Series: 'Neuroimmune interactions: how the nervous and immune systems influence each other', a collection of four Review articles commissioned by Leonie S. Taams from leading researchers in this exciting interdisciplinary field. The collection c...


Neuroimmune interactions in chronic pain - an interdisciplinary perspective.

It is widely accepted that communication between the nervous and immune systems is involved in the development of chronic pain. At each level of the nervous system, immune cells have been reported to accompany and frequently mediate dysfunction of nociceptive circuitry; however the exact mechanisms are not fully understood. One way to speed up progress in this area is to increase interdisciplinary cross-talk. This review sets out to summarize what pain research has already learnt, or indeed might still lear...

Autonomic Regulation of T-lymphocytes: Implications in Cardiovascular Disease.

The nervous and immune systems both serve as essential assessors and regulators of physiological function. Recently, there has been a great interest in how the nervous and immune systems interact to modulate both physiological and pathological states. In particular, the autonomic nervous system has a direct line of communication with immune cells anatomically, and moreover, immune cells possess receptors for autonomic neurotransmitters. This circumstantial evidence is suggestive of a functional interplay be...


Frank Beach Award Winner - The future of mental health research: Examining the interactions of the immune, endocrine and nervous systems between mother and infant and how they affect mental health.

Pregnancy and the postpartum period are periods of significant change in the immune and endocrine systems. This period of life is also associated with an increased risk of mental health disorders in the mother, and an increased risk of developmental and neuropsychiatric disorders in her infant. The collective data described here supports the idea that peripartum mood disorders in mother and developmental disorders in her infant likely reflects multiple pathogeneses, stemming from various interactions betwee...

Immune Cell Neural Interactions and their contributions to Sickle Cell Disease.

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Cellular and soluble mediators create an inflammatory and neuroinflammatory microenvironment contributing to neurogenic inflammation a...

Interleukin-4 and Interleukin-13 Evoke Scratching Behaviour in Mice.

Molecular cross-talk between the immune system and the nervous system elicit evolutionary responses such as itch (pruritus) to protect the host from potential pathogens . This neuroimmune, physiological response serves notably to remove pathogens from the skin . Pruritus can also be associated with inflammatory disorders such as atopic dermatitis (AD) . Indeed, AD is a common skin disease in which IL-4 and IL-13 are key players in inflammation and neuroimmune dysfunction.

Neural stimulations regulate the infiltration of immune cells into the CNS.

The systemic regulation of immune reactions by the nervous system is well studied and depends on the release of hormones. Some regional regulations of immune reactions, on the other hand, depend on specific neural pathways. Better understanding of these regulations will expand therapeutic applications for neuroimmune and organ-to-organ functional interactions. Here we discuss one regional neuroimmune interaction, the gateway reflex, which converts specific neural inputs into local inflammatory outputs in th...

Neuroinflammation During RNA Viral Infections.

Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral encephalitis in immunocompetent individuals is low, suggesting efficient mechanisms of virologic control within the CNS. Both immune and neural cells participate in this process, which requires extensive innate immune signaling between resident and infiltrating cells, including microglia and monocytes, that regulate the effecto...

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats.

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioural disorders with morphological and functional brain abnormalities. However, there is a growing body of evidence that abnormalities in the immune and endocrine systems may also account for the ADHD pathogenesis.

The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions with the Epithelium.

The intestinal epithelium does not function in isolation, but interacts with many components including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium interactions requires multidisciplinary approaches to uncover cells involved, mechanisms used, and the ultimate influence on intestinal physiology. This review is intended to serve as a reference for epithelial biologists interested in studying these interactions. With this in mind, this review serves to cover the basic anatomy o...

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses.

Immunosenescence contributes to a decreased capacity of the immune system to respond effectively to infections or vaccines in the elderly. The full extent of the biological changes that lead to immunosenescence are unknown, but numerous cell types involved in innate and adaptive immunity exhibit altered phenotypes and function as a result of aging. These manifestations of immunosenescence at the cellular level are mediated by dysregulation at the genetic level, and changes throughout the immune system are, ...

Thermodynamic insights and molecular environments into catanionic surfactant systems: Influence of chain length and molar ratio.

Imidazolium-based Ionic liquids as new generation cationic surfactants can provide designable alkyl chain length. In the catanionic surfactant systems, the alkyl chain lengths and molar ratios can greatly influence the interactions such as electrostatic and hydrophobic interaction. The variation in these interactions has a significant effect on the molecular environments of the self-assembly structure, and this process is always accompanied by the transition of aggregates and release or consumption of heat....

Overcoming trivialization: The neuroimmune response after acute central nervous system injury.

Vitamin D as an immune modulator in multiple sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system. The disease is characterised by inflammation with extensive immune infiltration, demyelination, axonal loss and damage of oligodendrocytes, presumably auto-immune in nature. The influence of environmental factors on the development and activity of MS has been known for a long time. Vitamin D and sun exposure are among the most important ones. Both serum vitamin D level and sun exposure independent...

Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry.

The hypothesis that the neuroimmune system plays a role in the pathogenesis of different psychiatric disorders, including schizophrenia, depression, and bipolar disease, has attained increasing interest over the past years. Previously thought to have the sole purpose of protecting the central nervous system (CNS) from harmful stimuli, it is now known that the central immune system is critically involved in regulating physiological processes including neurodevelopment, synaptic plasticity, and circuit mainte...

Itching for an Answer: A Review of Potential Mechanisms of Scalp Itch in Psoriasis.

Scalp psoriatic itch is a common complaint and often poses a therapeutic challenge. The pathophysiology of this phenomenon is unclear. The unique anatomy of the scalp contains richly innervated hair follicles, abundant vasculature and perifollicular inflammatory cytokines which may all contribute to this common sensory complaint. The mast cell, in particular, is portrayed as one of the main itch conductors for its ability to trigger neurogenic inflammation, activate the peripheral hypothalamic pituitary adr...

The 25th Scientific Conference of the Society on Neuroimmune Pharmacology: Program and Abstracts.

Sphingosine-1-phosphate signaling in blood pressure regulation.

Sphingolipids were originally believed to play a role only as a backbone of mammalian cell membranes. However, sphingolipid metabolites, especially sphingosine-1-phosphate (S1P), are now recognized as new bioactive signaling molecules that are critically involved in numerous cellular functions of multiple systems including the immune system, central nervous system, and cardiovascular system. S1P research has accelerated in the last decade as new therapeutic drugs have emerged that target the S1P signaling a...

Alterations in Blood Monocyte Functions in Parkinson's Disease.

PD is a multisystem disease where both central and peripheral nervous systems are affected. This systemic involvement also includes the immune response in PD, which implicates not only microglia in the brain, but also peripheral immune cells, such as monocytes; however, this aspect has been understudied.

Microglia: Lifelong Patrolling Immune Cells of the Brain.

Microglial cells are the predominant parenchymal immune cell of the brain. Recent evidence suggests that like peripheral immune cells, microglia patrol the brain in health and disease. Reviewing these data, we first examine the evidence that microglia invade the brain mesenchyme early in embryonic development, establish residence therein, proliferate and subsequently maintain their numbers throughout life. We, then, summarize established and novel evidence for microglial process surveillance in the healthy ...

Recruiting the Immune System against Disease: Lessons for Clinical and Systems Pharmacology.

Exposure-response analyses based on pharmacokinetics (PK) and pharmacodynamics (PD) offer great promise in research and development for vaccination and immunotherapy. While clinical and systems pharmacology integrate actionable multiscale information, quantitative immunology has focused on structural models of immune responses, without data-based calibration or prediction. Given growing immune datasets, and to facilitate a systems approach to immunomodulation, we propose a paradigm shift where the immune-re...

Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord.

Imaging the dynamic interactions between immune cells, glia, neurons and the vasculature in living rodents has revolutionized our understanding of physiological and pathological mechanisms of the CNS. Emerging microscopy and imaging technologies have enabled longitudinal tracking of structural and functional changes in a plethora of different cell types in the brain. The development of novel methods also allowed stable and longitudinal optical access to the spinal cord with minimum tissue perturbation. Thes...

Immunofluorescent characterization of innervation and nerve-immune cell neighborhood in mouse thymus.

The central nervous system impacts the immune system mainly by regulating the systemic concentration of humoral substances, whereas the peripheral nervous system (PNS) communicates with the immune system specifically according to local "hardwiring" of sympathetic/parasympathetic (efferent) and sensory (afferent) nerves to the primary and secondary lymphoid tissue/organs (e.g., thymus spleen and lymph nodes). In the present study, we use immunofluorescent staining of neurofilament-heavy to reveal the distrib...

The Immune System and Its Dysregulation with Aging.

Aging leads to numerous changes that affect all physiological systems of the body including the immune system, causing greater susceptibility to infectious disease and contributing to the cardiovascular, metabolic, autoimmune, and neurodegenerative diseases of aging. The immune system is itself also influenced by age-associated changes occurring in such physiological systems as the endocrine, nervous, digestive, cardio-vascular and muscle-skeletal systems. This chapter describes the multidimensional effects...

Metabolism at the centre of the host-microbe relationship.

Maintaining homeostatic host-microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. Yet, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host-microbe relationship. It will look at the central role of epithelial metabolism ...


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