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A 1-month-old male infant, only breastfed from birth, developed a localized edema of the hands and feet a few minutes after his first ingestion of a cow's milk (CM) formula. A complete allergy work-up showed positive skin prick test (SPT) to CM (7-mm wheal) and serum-specific IgE (s-IgE) (ImmunoCAP, Phadia, Uppsala, Sweden) to CM and CM proteins (s-IgE to CM 62.3 kUA/l, alpha-lactoalbumin 79.1 kUA/ml, beta-lactoglobulin 34.7 kUA/l, casein 98.7 kUA/l, total serum IgE 501 kU/l), allowing for a reliable diagno...