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PubMed Journals Articles About "RITA CORPORATION" RSS

03:32 EST 24th January 2019 | BioPortfolio

RITA CORPORATION PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest RITA CORPORATION articles that have been published worldwide.

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Showing "RITA CORPORATION" PubMed Articles, all 8

RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways.

Targeting oncogenic signaling pathways by small molecules has emerged as a potential treatment strategy for cancer. reactivation of p53 and induction of tumor cell apoptosis (RITA) is a promising anticancer small molecule that reactivates p53 and induces exclusive apoptosis in tumor cells. Less well appreciated was the possible effect of small molecule RITA on p53-null leukemia cells. In this study, we demonstrated that RITA has potent antileukemic properties against p53-null chronic myeloid leukemia (CML)-...


RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism.

Overactivation of the Hedgehog (HH) signaling pathway is implicated in many cancers. In this study, we demonstrate that the small molecule RITA, a p53 activator, effectively downregulates HH signaling in human medulloblastoma and rhabdomyosarcoma cells irrespective of p53. This is mediated by a ROS-independent activation of the MAP kinase JNK. We also show that in vitro RITA sensitized cells to the GLI antagonist GANT61, as co-administration of the two drugs had more pronounced effects on cell proliferation...

Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma.

Glioblastoma multiforme (GBM) is a malignant and aggressive central nervous system (CNS) tumor with high mortality and low survival rate. Effective treatment of GMB is a challenge worldwide. Temozolomide (TMZ) is a drug used to treat GBM, while the survival period of GBM patients with positive treatment remains less than 15 months. Reactivating p53 and Inducing Tumor Apoptosis (RITA) is a novel potential anti-cancer small molecular drug. Thus, it is essential to discover novel targets or develop effective d...


Expression patterns of heat shock protein genes in Rita rita from natural riverine habitat as biomarker response against environmental pollution.

River pollution is one of the principal environmental concerns and biomonitoring tools can play an important role in pollution assessment in the riverine environment. Heat shock proteins (Hsps) have been found to be suitable tools for monitoring stress response. In the present study, expression analyses of hsp genes (hsp27, hsp47, hsp60, hsp70, hsc70, and hsp90) and selected hsp-regulatory genes (hsf1, hyou1, ask1, jnk) were carried out by RT-qPCR in catfish Rita rita collected from selected stretches of ri...

Reply to the Letter Regarding the Article: "Oral Health - Factors of Non-Adherence to Dental Vouchers: A Case- Control Study" by Rita Filipe and Pedro Aguiar.

Letter to the Editor Regarding the Article: "Oral Health - Factors of Non-Adherence to Dental Vouchers: A Case- Control Study" by Rita Filipe and Pedro Aguiar. Acta Med Port 2018 Jun;31(6):303-311.

Patients With Breast Cancer: Report From a National Hospital-Based Cancer Registry in Argentina, 2012 to 2016.

To describe sociodemographic, epidemiologic, and clinical characteristics of patients who were diagnosed with breast cancer and registered in the Institutional Tumor Registry of Argentina (RITA) as of April 2016.

Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases.

Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article.


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