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PubMed Journals Articles About "Rapid Characterization Formulated Pharmaceuticals Using Fast Solid State" RSS

21:33 EDT 24th June 2019 | BioPortfolio

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Showing "Rapid Characterization Formulated Pharmaceuticals Using Fast Solid State" PubMed Articles 1–25 of 20,000+

Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1H Solid-State NMR Spectroscopy 
.

Active pharmaceutical ingredients (APIs) can be prepared in many different solid forms and phases that affect their physicochemical properties and suitability for oral dosage forms. The development and commercialization of dosage forms require analytical techniques that can determine and quantify the API phase in the final drug product. 13C solid-state NMR (SSNMR) spectroscopy is widely employed to characterize pure and formulated solid APIs; however, 13C SSNMR experiments on dosage forms with low API loadi...


Supercritical CO fluid extraction of croton crassifolius Geisel root: Chemical composition and anti-proliferative, autophagic, apoptosis-inducing, and related molecular effects on A549 tumour cells.

The use of plant essential oils as pharmaceuticals is a fast-growing market especially in China. Throughout the 20th century, a rapid increase took place in the use of many essential oil-derived products in the medicinal industry as nutraceuticals, medicinal supplements, and pharmaceuticals.

State of the Art of Pharmaceutical Solid Forms from Crystal Property Issues to Nanocrystals Formulation.

The solid form screening of active principal ingredients is a challenge for the pharmaceutical drug development since more than 80% of the marketed drugs are formulated in the solid form. A broad and comprehensive study of the various solid forms of the matter is needed to enhance its translation to clinic. Therefore, the most suitable solid form has to be taken into consideration regarding ex- and in-vivo stability, targeting, solubility, dissolution rate, and bioavailability. In this review, techniques of...


Synthesis and Characterization of Single Phase Metal Dodecaboride Solid Solutions: ZrYB and ZrUB.

Single-phase metal dodecaboride (MB) solid solutions, ZrYB and ZrUB were prepared by arc melting from the pure elements. The phase purity and composition were established by powder X-ray diffraction (PXRD), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and B and B solid-state nuclear magnetic resonance (NMR) spectroscopy. The effects of carbon addition to ZrYB were studied and it was found that carbon causes fast cooling and as a result rapid nucleation of grains, as wel...

Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals.

In vitro to in vivo extrapolation (IVIVE) is a critical component of the efforts to prioritize and assess environmental chemicals using high-throughput in vitro assays. The plasma unbound fraction (Fub) is a key toxicokinetic parameter in IVIVE, and is usually measured via the Rapid Equilibrium Dialysis (RED) assay widely used for pharmaceuticals. However, pharmaceuticals have a narrower range of physicochemical properties than environmental chemicals. Motivated by the observation that high LogK compounds a...

Occurrence, removal and seasonal variation of pharmaceuticals in Brasilian drinking water treatment plants.

The presence of pharmaceuticals in aquatic environments has become a major issue of concern for scientific community, since there is a lack of information about risks and impacts to the environment and public health. In the context of Brazil, many cities do not have Wastewater Treatment Plants (WWTPs) and domestic sewage is dumped directly into the water bodies, aggravating the problem. Thus, the present study aimed to evaluate the presence of 28 prescribed pharmaceuticals from different therapeutic classes...

Edible solid foams as porous substrates for inkjet-printable pharmaceuticals.

The aim of this study was to investigate new porous flexible substrates, i.e., solid foams that would serve as a carrier with a high ink absorption potential for inkjet printable pharmaceuticals. Propranolol hydrochloride was used as a model active pharmaceutical ingredient (API). Pharmaceutically approved and edible cellulose derivatives and gums together with different additives were evaluated as a base for the substrate. Different methods for preparation of a solid foam such as freeze-drying, vacuum oven...

Solid-State Photochromism by Molecular Assembly of Bis-o-Carboranyl Siloles.

A new type of solid-state photochromism was observed in an AB2 type molecular assembly comprising the central silole and two peripheral o-carborane units, and in this assembly, depending on the assembling positions of those units at the adjoining benzene ring, two different regioisomers were formed: Si-m-Cb and Si-p-Cb. Each isomer showed different solid-state photochromism depending on its solid-state conformation and was either in the crystalline or amorphous state. The crystals of each meta- or para-isom...

Characterizing the fluctuations of dynamic resting-state electrophysiological functional connectivity: Reduced neuronal coupling variability in mild cognitive impairment and dementia due to Alzheimer's disease.

The characterization of brain functional connectivity is a helpful tool in the study of the neuronal substrates and mechanisms that are altered in Azheimer's Disease (AD) and mild cognitive impairment (MCI). Recently, there has been a shift towards the characterization of dynamic functional connectivity (dFC), discarding the assumption of connectivity stationarity during the resting-state. The majority of these studies have been performed with functional magnetic resonance imaging (fMRI) recordings, with on...

Occurrence and distribution of pharmaceuticals in raw, finished, and drinking water from seven large river basins in China.

The occurrence of pharmaceuticals in the drinking water is a growing concern in China. In this study, we determined the concentration and distribution of 59 selected pharmaceuticals in raw, finished, and tap water samples from 79 drinking water treatment plants (DWTPs) in 15 cities, encompassing seven large river basins in China, using solid-phase extraction pretreatment and ultra-high-performance liquid chromatography-tandem mass spectrometry analysis. Forty-seven pharmaceuticals were detected in raw water...

Highly-Substituted 1,2,3-Triazolines: a New Class of Solid State Emitters with Electrofluorochromic Behavior.

Highly-substituted Δ3-1,2,3-triazolines can be prepared by reaction of triarylvinyl Grignard reagents with functionalized organic azides. The heterocycles are fluorescent in solid state, and - depending on the substituents - they can display aggregation-induced emission. Upon oxidation, the triazolines form stable radical cations with altered photophysical properties. Therefore, they represent rare examples of solid state emitters with intrinsic electrofluorochromic behavior.

Water dynamics during solid-state fermentation by Aspergillus oryzae YH6.

Water is crucial for microbial growth, heat transfer and substrate hydrolysis, and dynamically changes with time in solid-state fermentation. However, water dynamics in the solid substrate is difficult to define and measure. Here, nuclear magnetic resonance was used to monitor water dynamics during the pure culture of Aspergillus oryzae YH6 on wheat in a model system to mimic solid starter (Qu or Koji) preparation. During fermentation, overall water content gradually decreased from 0.84 to 0.36 g/g, and w...

Solid state ionics of hybrid halide perovskites.

Many exciting "anomalies" affecting long-time and low-frequency phenomena in the photo-active halide perovskites that are presently in the focus of the field of photovoltaics turn out to be rather expected from the point of view of Solid State Ionics. This paper discusses such issues based on the mixed conducting nature of these materials, and indicates how the Solid State Ionics toolbox can be used to condition and potentially improve these solids. In addition to equilibrium bulk properties, interfacial ef...

An Electron/Ion Dual-Conductive Alloy Framework for High-Rate and High-Capacity Solid-State Lithium-Metal Batteries.

The solid-state Li battery is a promising energy-storage system that is both safe and features a high energy density. A main obstacle to its application is the poor interface contact between the solid electrodes and the ceramic electrolyte. Surface treatment methods have been proposed to improve the interface of the ceramic electrolytes, but they are generally limited to low-capacity or short-term cycling. Herein, an electron/ion dual-conductive solid framework is proposed by partially dealloying the Li-Mg ...

Exploiting in-situ solid-state NMR spectroscopy to probe the early stages of hydration of calcium aluminate cement.

We report a high-field in-situ solid-state NMR study of the hydration of CaAlO (the most important hydraulic phase in calcium aluminate cement), based on time-resolved measurements of solid-state Al NMR spectra during the early stages of the reaction. A variant of the CLASSIC NMR methodology, involving alternate recording of direct-excitation and MQMAS Al NMR spectra, was used to monitor the Al species present in both the solid and liquid phases as a function of time. Our results provide quantitative inform...

Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions.

Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should h...

Chitosan/beidellite nanocomposite as diclofenac carrier.

Chitosan (CS) and purified sodium beidellite (Na-Bd) were used to obtain a nanocomposite able to carry anionic pharmaceutical ingredients. Diclofenac sodium (DS) was chosen as a model drug and was loaded by intercalation solution technique. Solid state characterization of the resultant hybrids was performed, including X-ray diffraction, Fourier transformed infrared spectroscopy, Thermal analysis and high resolution transmission electron microscopy coupled with energy dispersive X-Ray analysis. Drug loading ...

Solid-State Anaerobic Digestion for Waste Management and Biogas Production.

Solid-state anaerobic digestion (SS-AD) is commonly used to treat feedstocks with high solid content such as municipal solid waste and lignocellulosic biomass. Compared to liquid state anaerobic digestion (LS-AD), SS-AD has multiple advantages including high organic loading, minimal digestate generated, and low energy requirement for heating. However, the main disadvantages limiting the efficiency of SS-AD are long solid retention time, incomplete mixing, and an accumulation of inhibitors. For a successful ...

A fully automatic cross used solid-phase extraction online coupled with ultra-high performance liquid chromatography-tandem mass spectrometry system for the trace analysis of multi-class pharmaceuticals in water samples.

A fully automatic system, which integrated cross used solid-phase extraction with ultra-high performance liquid chromatography-tandem mass spectrometry, was developed and validated for the simultaneous determination of multi-class pharmaceuticals (62 in total) in Milli-Q water, tap water, lake water, and ground water. The online system allowed the cross-utilization of two SPE columns without significant carryover and achieved an automatic, sensitive and fast analysis, requiring about 14 min per analysis. ...

High Safety All-Solid-State Lithium Metal Battery with High Ionic Conductivity Thermoresponsive Solid Polymer Electrolyte.

Lithium metal batteries (LMB) are very attractive owing to their high theoretical energy density, but significant challenges such as low ionic conductivity and safety risks prevent their widespread application. Herein we report a new design of high safety all-solid-state LMB by using high ionic conductive thermoresponsive solid polymer electrolyte (TSPE), providing a smart and active approach to realize thermally-induced autonomic shutdown of LMBs by efficiently inhibiting the ionic conduction between elect...

Electronic Transport through DNA Nucleotides in Atomically Thin Phosphorene Electrodes for Rapid DNA Sequencing.

Rapid progresses in developing the fast, low-cost, and reliable methods for DNA sequencing are envisaged for development of personalized medicine. In this respect, nanotechnology has paved the role for the development of advanced DNA sequencing techniques including sequencing with solid-state nanopores or nanogaps. Herein, we have explored the application of a black phosphorene based nanogap-device for DNA sequencing. Using density-functional-theory (DFT) based non-equilibrium Green's function (NEGF) approa...

Efficient 263 GHz magic angle spinning DNP at 100 K using solid-state diode sources.

The development of new, high-frequency solid-state diode sources capable of operating at 263 GHz, together with an optimized stator design for improved millimeter-wave coupling to the NMR sample, have enabled low-power DNP experiments at 263 GHz/400 MHz. With 250 mW output power, signal enhancements as high as 120 are achieved on standard samples - approximately 1/3 of the maximal enhancement available with high-power gyrotrons under similar conditions. Diode-based sources have a number of advantages ...

Polymer Electrolyte Glue: A Universal Interfacial Modification Strategy for All-Solid-State Li Batteries.

In recent years solid Li+ conductors with competitive ionic conductivity to those of liquid electrolytes have been reported. However, the incorporation of highly conductive solid electrolytes into the lithium-ion batteries is still very challenging mainly due to the high resistance existing at the solid-solid interfaces throughout the battery structure. Here, we demonstrated a universal interfacial modification strategy through coating a curable polymer-based glue electrolyte between the electrolyte and ele...

No fear for Perfluorinated Peroxides: Syntheses and Solid State Structures of Surprisingly inert Perfluoroalkyl Peroxides.

We report on the solid state structures of bis(nonafluoro-tert-butyl) peroxide [(F3C)3CO]2 and bis(undecafluoro-2-methyl-2-butyl) peroxide [(C2F5)(F3C)2CO]2. These peroxides are prepared from the corresponding hypofluorites with fluorinated silver wool. Their solid state structures obtained by in situ crystallization show unusual COOC dihedral angles of 180°, as well as elongated O-O bonds as a result of the bulky perfluorinated alkyl groups. The perfluorinated alkyl peroxides are insensitive to both, impa...

Structural and functional characterization of fast-cycling RhoF GTPase.

Ras superfamily GTPases are molecular switches that cycle between GDP-bound inactive state and GTP-bound active state to control many signaling pathways. Emerging evidence suggests that several Ras superfamily GTPases, including RhoF, do not follow the classical GDP/GTP exchange cycle; they act as constitutively active GTP-bound proteins due to their fast activities of GDP/GTP exchange (termed as 'fast-cycling' GTPases). To understand the molecular basis of the fast-cycling GTPases, we generated a GTPase ac...


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