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We recently discussed several limitations of Bayesian leave-one-out cross-validation (LOO) for model selection. Our contribution attracted three thought-provoking commentaries. In this rejoinder, we address each of the commentaries and identify several additional limitations of LOO-based methods such as Bayesian stacking. We focus on differences between LOO-based methods versus approaches that consistently use Bayes' rule for both parameter estimation and model comparison. We conclude that LOO-based methods...
Emeritus Professor Jonathan Clemence Peter passed away in Wynberg, Cape Town, on April 02, 2018, after an illness confronted with quiet courage and dignity. A beloved father, husband, neurosurgeon, leader, teacher, mentor and friend, he is remembered with deep respect and affection throughout the world of paediatric neurosurgery.
Call it fate, karma, destiny. It was written in his stars, in his professional DNA. It had to happen. Houston pediatrician and microbiologist Peter Hotez, MD, PhD, just had to write Vaccines Did Not Cause Rachel's Autism.
Peter Godfrey-Faussett and colleagues present six epidemiological metrics for tracking progress in reducing the public health threat of HIV.
Vertebral Tethering for Scoliosis Management: Commentary on an article by Peter O. Newton, MD, et al.: "Anterior Spinal Growth Tethering for Skeletally Immature Patients with Scoliosis. A Retrospective Look Two to Four Years Postoperatively".
The orbitofrontal cortex is a large and heterogeneous cortical area on the ventral surface of the frontal lobe and is intimately involved in emotion and executive function. In this Primer, Peter Rudebeck and Erin Rich summarize our understanding of the mechanisms through which orbitofrontal cortex adaptively shapes decision making and affective behavior.
The speech deals with the role of the German Public Health Service during the period of national socialism and some resulting consequences for the present public health activities in Germany.
The nucleolus is a subnuclear compartment, which governs ribosome biogenesis. Moreover, it functions as hub in the stress response by orchestrating a variety of processes, such as regulation of cell cycle progression, senescence and apoptosis. Emerging evidence links the nucleolus also to the control of genomic stability and the development of human malignancies. Peter Pan (PPAN) is an essential ribosome biogenesis factor localized to nucleoli and mitochondria. We earlier showed that PPAN depletion triggers...
A Sequential Parallel Comparison Design has two stages, the first comparing drug to placebo and the second comparing drug to placebo among patients who did not respond to placebo in the first stage. The paper, Statistical Inference Problems in Sequential Parallel Designs, claims that the estimate of the treatment difference in the second stage is biased and that under certain circumstances, a suggested hypothesis test will reject the null hypothesis when it should be accepted. This rejoinder argues that the...
Ting-Kai (T-K) Li, MD died on November 18, 2018, just five days after his 84 birthday. T-K had a wonderful and distinguished academic and public service career, spanning almost five decades. Born in Nanjing, China, T-K fled with his family to South Africa during World War II, while a young boy. He initially enrolled in the University of the Witwatersrand but eventually made his way to Chicago where he obtained his undergraduate degree at Northwestern University prior to attending Harvard Medical School. T-K...
In this issue of Acta Physiologica, a study from the laboratory of Peter Larsson shows that the distance between the carboxyl group and the first double bond of polyunsaturated fatty acids (PUFAs) is critical for the affinity of the PUFA molecule to a voltage-gated potassium channel found in the heart . A shorter distance increases the affinity, and the bound PUFA alters the channel's voltage dependence and thereby opens the channel. The efficacy, that is the channel-opening effect of a bound PUFA molecule,...
Individuals with HIV infection are living longer, and are at risk of autoimmune disorders and cancers associated with aging. Many of these conditions are treated with immunobiologic agents that affect immune function and may increase risk of opportunistic infections (OIs) and other immune disorders in individuals with HIV infection. For example, tumor necrosis factor-alpha inhibitors, used to treat such disorders as Crohn's disease, are associated with risk of tuberculosis and histoplasmosis. Rituximab, use...