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Response Naidoo Letter Regarding Article Early Life Factors PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Response Naidoo Letter Regarding Article Early Life Factors articles that have been published worldwide.
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Depression is considered as a maladaptive response to stress in adult life. Exposure to stress in early childhood is recognized as a risk factor for being unable to adapt to environmental changes in adult life. Early life stress (ELS) has been modelled in animals to help understand the behavioral outcome of the adversity. Periodic maternal separation (MS) in rodents for the first two weeks of life is one such model. We used MS as a form of ELS in Balb/c mice to study its effect on a stressful challenge enco...
Thank you for the opportunity to respond to the letter of Drs. Dani and Pittella concerning our recently published article "Neuropathological lesions in the very old: results from a large Brazilian autopsy study" (5). In this work analyzing the distribution of common neuropathological lesions associated with cognitive decline in individuals who died between the 6 and 8 decade of life vs. older individuals, we found a higher frequency of neuropathological lesions in the very old group.
Early-life exposures, such as prenatal maternal lifestyle, illnesses, nutritional deficiencies, toxin levels, and adverse birth events, have long been considered potential risk factors for neurodevelopmental disorders in offspring. However, maternal genetic factors could be confounding the association between early-life exposures and neurodevelopmental outcomes in offspring, which makes inferring a causal relationship problematic.
To determine the magnitude of relationships of early life factors with child development in low/middle-income countries (LMICs).
1.The early life environment can have profound, long-lasting effects on an individual's fitness. For example, early life quality might (1) positively associate with fitness (a silver spoon effect), (2) stimulate a predictive adaptive response (by adjusting the phenotype to the quality of the environment to maximize fitness) or (3) be obscured by subsequent plasticity. Potentially, the effects of the early life environment can persist beyond one generation, though the intergenerational plasticity on fitness ...
Stress is an adaptive response to environment aversive stimuli and a common life experience of one's daily life. Chronic or excessive stress especially that happened in early life is found to be deleterious to individual's physical and mental health, which is highly related to depressive disorders onset. Stressful life events are consistently considered to be the high-risk factors of environment for predisposing depressive disorders. In linking stressful life events with depressive disorder onset, dysregula...
Previous studies have suggested that exposures to indoor air-polluting factors during pregnancy and early life can influence childhood allergy development. These exposures have been investigated in singularity, however the effect of simultaneous exposure to multiple factors remains unclear.
Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown.
Our aim was to study the association between early-life factors and the development of endometriosis.
Individual variation in survival probability due to differential responses to early-life environmental conditions is important in the evolution of life-histories and senescence. A biomarker allowing quantification of such individual variation, and which links early-life environmental conditions with survival by providing a measure of conditions experienced, is telomere length. Here, we examined telomere dynamics among 24 cohorts of European badgers (Meles meles). We found a complex cross-sectional relations...
Intergenerational fitness effects on offspring due to the early life of the parent are well studied from the standpoint of the maternal environment, but intergenerational effects owing to the paternal early life environment are often overlooked. Nonetheless, recent laboratory studies in mammals and ecologically relevant studies in invertebrates predict that paternal effects can have a major impact on the offspring's phenotype. These non-genetic, environment-dependent paternal effects provide a mechanism for...
Adolescents' evaluation of overall life in response to adverse life circumstances may depend on the features of events as well as the resources of the youngsters, but there is a lack of research examining whether these factors relate to life satisfaction trajectories from early adolescence to late adolescence (ranging from age 12 to 19). This study analyzes whether controllable negative life events, internal resources, (e.g., self-efficacy) and external resources, (e.g., three sources of social support) pre...
Much research finds that early life socioeconomic disadvantage predicts poorer health later in life, even among those whose conditions improve in adulthood. Although there are numerous factors that contribute to this association, recent research suggests that growing up in adverse socioecological environments may promote developmental patterns that facilitate pre-reproductive survival in harsh environments, but can also come at the cost of reduced longevity. Here, we review recent research demonstrating tha...
Thank you for your interest in our article: The Impact of Post-Reperfusion Syndrome During Liver Transplantation Using Livers with Significant Macrosteatosis . The goal of our study was to demonstrate the very real risk of significant post-reperfusion syndrome and potential for cardiac arrest at the time of reperfusion when using livers with documented macrosteatosis of ≥30%. As the authors of the letter state, post-reperfusion syndrome is not unique to this situation and can be seen with a variety of ...
Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been implicated in mood and anxiety disorders and is upregulated by antidepressants. It has marked effects on synaptic and extra-synaptic plasticity through tropomyosin receptor kinase B (TrkB). Importantly, early life stressors that affect BDNF production are known to predispose individuals towards the later development of depression or anxiety disorders. Yet, few studies have actually assessed the long-term impact of selective early life ...