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PubMed Journals Articles About "Role Oligoethylene Glycol Side Chain Length Responsive Polymeric" RSS

05:59 EDT 20th June 2019 | BioPortfolio

Role Oligoethylene Glycol Side Chain Length Responsive Polymeric PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Role Oligoethylene Glycol Side Chain Length Responsive Polymeric articles that have been published worldwide.

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Showing "Role Oligoethylene Glycol Side Chain Length Responsive Polymeric" PubMed Articles 1–25 of 30,000+

Role of Oligoethylene Glycol Side Chain Length in Responsive Polymeric Nanoassemblies.

An oft-desired feature of a responsive nanomaterial is for it to undergo disassembly or morphological change upon application of a specific stimulus. The extent of response has been found to depend on factors such as the nature and the number of responsive functionalities incorporated into these particles. In this work, the length of oligoethyleneglycol (OEG) side chains associated with the polymers has been shown to greatly influence the responsive behavior of polymeric nanoparticles. The integrity of thes...


Conjugated Polymers with Oligoethylene Glycol Side Chains for Improved Photocatalytic Hydrogen Evolution.

Conjugated polymers are emerging as promising organic photocatalysts for hydrogen evolution from water. However, it is still very challenging for conjugated polymers to realize highly efficient photocatalytic hydrogen evolution. Herein, we demonstrate an efficient strategy of hydrophilic side chain functionalization to boost the hydrogen evolution rates of conjugated polymers. By functionalizing conjugated polymers with hydrophilic oligo (ethylene glycol) monomethyl ether (OEG) side chains, a 90-fold improv...

Dual-responsive pegylated polypeptoids with tunable cloud point temperatures.

A series of pegylated polypeptoids have been readily synthesized by a strategy combining ring-opening polymerization (ROP) and thiol-yne photoaddition. The polypeptoids simultaneously incorporated branched oligo(ethylene glycol) (OEG) units and thioether bonds in the side-chains. All the polypeptoids are readily soluble in aqueous solution and show reversible thermo-responsive properties. The cloud points (CPs) were demonstrated to be readily tunable in the range of ~25°C-60°C by varying the chemical comp...


Influence of side chain isomerism on the rigidity of poly(3-alkylthiophenes) in solutions revealed by neutron scattering.

Using small-angle neutron scattering, we conducted a detailed conformational study of poly(3-alkylthiophene) solutions in deuterated dichlorobenzene. The focus was placed on addressing the influence of the spatial arrangement of side chain constituents on backbone conformation. We demonstrate that by introducing a branch point in the side chain, side chain steric interactions may promote torsional motion between backbone units, resulting in greater chain flexibility. Our findings highlight the key role of t...

Amphiphilic bromelain-synthesized oligo-phenylalanine grafted with methoxypolyethylene glycol possessing stabilizing thermo-responsive emulsion properties.

A thermo-responsive amphiphile was developed from oligo-phenylalanine [oligo(Phe)]. The hydrophobic moiety of the amphiphile, oligo(Phe) was synthesized via reverse hydrolysis catalyzed by bromelain in dimethyl sulfoxide and dioxane solutions. The production of oligo(Phe) increased by 80.7% by screening suitable reaction conditions. The average degree of polymerization of oligo(Phe) was determined to be four by H NMR. By grafting with aldehyde-ended methoxypolyethylene glycol (mPEG), oligo(Phe) was converte...

Fatty acid biosynthesis: Chain length regulation and control.

De novo biosynthesis of fatty acids undergoes an iterative process with strict regulation of the length of the produced fatty acids. In this review, we focus on the factors determining the chain length in fatty acid biosynthesis. In a nutshell, the process of chain length regulation can be understood as a competition between the output of a chain elongating C-C bond forming reaction and a terminating fatty acid release function. At the end of each cycle in the iterative process, the synthesizing enzymes nee...

Length of surface PEG modulates nanocarrier transcytosis across brain vascular endothelial cells.

Diblock PLA-PEG nanoparticles were produced to establish the role of PEG chain length on brain vascular endothelial cell transcytosis. 100-nm nanoparticles tagged with fluorescent pyrene butanol and coated with PEG chains (Mw: 1-10kDa), at similar PEG surface density, were used to study endocytosis and transcytosis phenomena on mouse vascular endothelial cell monolayers. The transport mechanisms were then investigated through inhibitory processes. Our results show that there is an evident correlation betwee...

Effect of arginine deimination and citrulline side chain length on secondary structure formation.

Post-translational modifications expand the chemical functionality beyond the encoded amino acids, but studies on the structural effects of these modifications have been limited. Arginine (Arg) undergoes deimination to give citrulline (Cit), converting the positively charged guanidinium group into a neutral urea group. Herein, we present the effect of Arg deimination on secondary structure formation. To understand the reason for the number of methylenes in Cit, the effect of Cit side chain length on seconda...

Formulation conditions on the drug loading properties of polymeric micelles.

Methyl poly(ethylene glycol) grafted poly (lactide-co-(glycolic acid)-alt-(glutamic acid) amphiphilic copolymers (PLG-g-mPEG) were fabricated polymeric micelles to load anticancer drug doxorubicin (DOX). Both blank and drug loaded micelles were spherical nanoparticles with the mean sizes around 50 and 100nm, respectively. The effects of formulation conditions including compositions, concentrations, temperature, feeding doses and solvents on the size and drug loading content were investigated, the storage of...

Self-assembly of short chain Poly-N-isopropylacrylamid (PNIPAM) induced by superchaotropic Keggin Polyoxometalates: from globules to sheets.

We show here for the first time that short chain poly(N-isopropylacrylamide) PNIPAM, one of the most famous thermo-responsive polymers, self-assembles in water to form (i) discrete nm-globules and (ii) micrometric sheets with nm-thickness upon addition of the well-known Keggin-type polyoxometalate (POM) H3PW12O40 (PW). The type of self-assembly is controlled by PW concentration: at low PW concentrations, PW adsorbs on PNIPAM chains to form globules consisting of homogeneously distributed PWs in PNIPAM dropl...

Stimulus-Responsive Polymeric Nanogels as Smart Drug Delivery Systems.

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or...

Biobased polymeric surfactant: Natural glycyrrhizic acid-appended homopolymer with multiple pH-responsiveness.

Even though amphiphilic natural products have been widely employed in cosmetics, food, and pesticide formulations, the development of a compound with stimuli-responsiveness is still highly significant. Inspired by the low cost, biocompatibility, pH resistance and amphiphilicity of natural glycyrrhizic acid (Gly), we designed and synthesized an amphiphilic homopolymer, namely, poly(glycyrrhizic acid) (PGly), via reversible addition-fragmentation chain transfer (RAFT) polymerization. The two carboxylic groups...

Alteration between inhibition and stimulation in individual and mixture effects of amimBr and apyrBr on Aliivibrio fischeri: Time and side-chain dependence.

The exposure reality of chemicals is usually in mixtures, the effects of which are usually extrapolated from individual results. Yet, such extrapolation is challenged by the alteration between monotonic concentration-response curves (CRCs) and non-monotonic hormetic CRCs in individual and mixture effects. In the present study, we aimed to investigate the occurrence of such alterations using 1-alkylimidazolium bromide ([amim]Br) and 1-alkylpyridinium bromide ([apyr]Br) ionic liquids (ILs) as model chemicals....

The cinnamaldehyde-based poly(ester-thioacetal) to generate reactive oxygen species for fabricating ROS-responsive nanoparticles.

Reactive oxygen species (ROS)-responsive nanoparticles have attracted great interest for anticancer drug delivery. In this paper, a new ROS-responsive moiety, thioacetal, was designed and synthesized, cinnamaldehyde (CA) was introduced in the polymer chain to trigger the generation of ROS to expect the enhancement of ROS-responsive effect. The poly(ester-thioacetal) mPEG2k-b-(NTA-HD)12 polymer, its self-assembled micelles and the ROS-responsive behavior were characterized by 1H NMR and DLS. Anticancer drug ...

Starburst diblock polyprodrugs: reduction-responsive unimolecular micelles with high drug loading and robust micellar stability for programmed delivery of anticancer drugs.

Polymeric prodrug based on therapeutic nanomedicine has demonstrated great promise for effective tumor growth inhibition, however, the drawbacks of low drug-loading and weak micellar stability limit its application for clinical cancer therapy. Herein, a reduction-responsive starburst block copolymer prodrug CCP [β-cyclodextrin (β-CD)-PCPTXX-POEGMA, xx: SS or CC] has been developed for cancer therapy. And CCP is composed of β-CD-Br core with multiple reactive sites, as well as a diblock copolymer containi...

Responsive Polymers as Smart Nanomaterials Enable Diverse Applications.

Responsive polymers undergo reversible or irreversible physical or chemical modifications in response to a change in environment or stimulus, e.g., temperature, pH, light, and magnetic or electric fields. Polymeric nanoparticles (NPs), which constitute a diverse set of morphologies, including micelles, vesicles, and core-shell geometries, have been successfully prepared from responsive polymers and have shown great promise in applications ranging from drug delivery to catalysis. In this review, we summarize...

Ramachandran maps for side chains in globular proteins.

The Ramachandran plot for backbone ϕ,ψ-angles in a blocked mono-peptide has played a central role in understanding protein structure. Curiously, a similar analysis for side chain χ-angles has been comparatively neglected. Instead, efforts have focused on compiling various types of side chain libraries extracted from proteins of known structure. Departing from this trend, the following analysis presents backbone-based maps of side chains in blocked mono-peptides. As in the original ϕ,ψ-plot, these maps ...

Lipase-Catalyzed Regioselective Synthesis of Dextrin Esters.

Four lipase enzymes were investigated as catalysts in the synthesis of regioselectively mono-substituted dextrin esters from dextrin and vinyl acetate. An immobilized lipase enzyme (Lipozyme TL IM) exhibited the highest activity. This enzyme showed regioselective substitution of the dextrin at the primary hydroxyl group (C6 position) under optimal conditions (60°C for 24 hours, using a 1:3 molar ratio of glucose unit/vinyl acetate and 2.5 U/mL enzyme dosage in an organic solvent). To compare the reactivity...

Branch ostial optimization treatment and optimized provisional t-stenting with polymeric bioresorbable scaffolds: Ex-vivo morphologic and hemodynamic examination.

The optimal side-branch (SB) ostium treatment after provisional side-branch scaffolding remains a subject of debate in bioresorbable vascular scaffold (BVS) era. In this study, we evaluated a novel optimized provisional T-stenting technique (OPT) and assessed its feasibility by comparison with T and small protrusion technique (TAP).Two provisional SB scaffolding techniques (OPT, n = 5; TAP, n = 5) were performed using polymeric BVS in a bifurcated phantom. The sequential intermediate snuggling ballo...

Pullulan-derived nanocomposite hydrogels for wastewater remediation: Synthesis and characterization.

Polysaccharide is a renewable, biocompatible and biodegradable material that has received considerable attention. In this work, a series of polysaccharide gels were synthesized from the chemical cross-linking of pullulan with diglycerols. The effects of the diglycerol chain length on the performance of the gels were evaluated by XRD, TGA, SEM, rheological testings and swelling measurements. Overall, increasing the chain length resulted in a smaller pore size and stronger mechanical strength. Tetramethylene ...

A Temperature-Responsive Boronate Core Cross-Linked Star (CCS) Polymer for Fast and Highly Efficient Enrichment of Glycoproteins.

Fast and highly efficient enrichment and separation of glycoproteins is essential in many biological applications, but the lack of materials with high capture capacity, fast, and efficient enrichment/separation makes it a challenge. Here, a temperature-responsive core cross-linked star (CCS) polymer with boronate affinity is reported for fast and efficient enriching and separating of glycoproteins from biological samples. The temperature-responsive CCS polymers containing boronic acid in its polymeric arms ...

Side-chain cleaved phytoecdysteroid metabolites as activators of protein kinase B.

Phytoecdysteroids exert their non-hormonal anabolic and adaptogenic effects in mammals, including humans, through a partially revealed mechanism of action involving the activation of protein kinase B (Akt). We have recently found that poststerone, a side-chain cleaved in vivo metabolite of 20-hydroxyecdysone, exerts potent anabolic activity in rats. Here we report the semi-synthetic preparation of a series of side-chain cleaved ecdysteroids and their activity on the Akt phosphorylation in murine skeletal mu...

Side Chain Dynamics of the Trifluoroacetone Cysteine Derivative Characterized by F NMR Relaxation and Molecular Dynamics Simulations.

F NMR spectroscopy is a powerful tool for the study of the structures, dynamics, and interactions of proteins bearing cysteine residues chemically modified with a trifluoroacetone group (CYF residue). F NMR relaxation rates for the fluoromethyl group of CYF residues are sensitive to overall rotational tumbling of proteins, fast rotation about the CF methyl axis, as well as the internal motion of the CYF side chain. To develop a quantitative understanding of these various motional contri-butions, we used the...

Photo-induced tyrosine side chain fragmentation in IgG4-Fc: mechanisms and solvent isotope effects.

Immunoglobulin gamma (IgG) monoclonal antibodies (mAbs) are glycoproteins that have emerged as powerful and promising protein therapeutics. During the process of production, storage and transportation, exposure to ambient light is inevitable, which can cause protein physical and chemical degradation. For mechanistic studies of photo-degradation, we have exposed IgG4-Fc to UV light. The photoirradiation of IgG4-Fc with monochromatic UVC light at λ = 254 nm and UVB light with λmax = 305 nm in air-saturated ...

Cyclization and Relaxation Dynamics of Finite-Length Collapsed Self-Avoiding Polymers.

We study the cyclization and relaxation dynamics of ideal as well as interacting polymers as a function of chain length N. For the cyclization time τ_{cyc} of ideal chains we recover the known scaling τ_{cyc}∼N^{2} for different backbone models, for a self-avoiding slightly collapsed chain we obtain from Langevin simulations and scaling theory a modified scaling τ_{cyc}∼N^{5/3}. The cyclization and relaxation dynamics of a finite-length collapsed chain scale differently; this unexpected dynamic multi...


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