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PubMed Journals Articles About "Selecting Excipients Forming Therapeutic Deep Eutectic Systems Mechanistic" RSS

18:13 EDT 24th June 2019 | BioPortfolio

Selecting Excipients Forming Therapeutic Deep Eutectic Systems Mechanistic PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Selecting Excipients Forming Therapeutic Deep Eutectic Systems Mechanistic articles that have been published worldwide.

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Showing "Selecting Excipients forming Therapeutic Deep Eutectic Systems mechanistic" PubMed Articles 1–25 of 22,000+

Selecting Excipients forming Therapeutic Deep Eutectic Systems - a mechanistic approach.

The majority of all newly identified active pharmaceutical ingredients (APIs) have a low solubility in water (partly smaller than marble). In order to enhance their solubility and bioavailability, the formulation of these APIs as part of therapeutic deep-eutectic systems (THEDES), has been recently shown to be a promising approach. By choosing the right excipient, the melting point of the API/excipient mixture can be lowered below body temperature or even room temperature, resulting in a liquid formulation....


Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator.

Fast dissolution of nonsteroidal anti-inflammatory drugs (NSAIDs) is a prerequisite from patient perspective. However, most NSAIDs are slowly dissolving acidic compounds. Caffeine, a commonly used analgesic adjuvant with NSAIDs showed high potential as eutectic co-former for acidic compounds. The study investigated eutectic forming potential of caffeine with meloxicam, aceclofenac and flurbiprofen. Each drug was co-ground with caffeine in various ratios and the products were characterized by thermal analysi...

A General and Facile Paradigm for the Electrochemical Reduction of Carbon Dioxide Inspired by Deep Eutectic Solvents.

We report the application of deep eutectic solvents (DESs) for the electrochemical CO2 reduction reaction (CO2RR). Choline-based DESs represent a non-toxic and inexpensive alternative to room temperature ionic liquids (RTILs) when employed as additives to the system or as electrolyte. Following the study on choline-based DESs we generalized this approach and devised simple and organic-soluble systems based on the combination of organic chloride salts with ethylene glycol (EG), allowing the chlorides to be r...


Successful development of oral SEDDS: Screening of excipients from the industrial point of view.

Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of infections can be avoided resulting in a comparatively high patient compliance. However, from the industrial point of view the development of oral delivery systems is still challenging as various drugs are poorly soluble as well as slightly permeable leading to low bioavailability. As self-emulsifying drug delivery systems are able to incorporate both hydrophobic and hydrophilic drugs, these car...

In the quest for green solvents design: from hydrophilic to hydrophobic (deep) eutectic solvents.

Deep eutectic solvents (DESs) consist of a mixture of two or more solid components leading to a drop of the melting point of the mixture when compared to the starting materials. Until recently, only hydrophilic DESs were available, and despite their revolutionary role in the alternative solvents scenario, important issues in chemistry and chemical engineering, such as water related problems or the replacement of toxic volatile organic compounds, could not be tackled. Hydrophobic (Deep) - here in parenthesis...

Characterization of the partition rate of ibuprofen across the water-octanol interface and the influence of common pharmaceutical excipients.

This work reports the measurement of the partition rate of a model drug, ibuprofen, from aqueous solutions into octanol with the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, HPMC, PVP, PVP-VA, HPMCAS, sodium dodecyl sulfate, Tween 80, and sodium taurocholate at varying concentrations. This attempts to assess the kinetic aspect of IBU partitioning across the water-octanol interface by applying a mechanistic model and to characterize the interfacial resis...

Development of a chemometric-assisted deep eutectic solvent-based microextraction procedure for extraction of caffeine in foods and beverages.

In this research article, a novel and green deep eutectic solvent-based microextraction (DES-ME) procedure based on chemometric-assisted (CA) optimization was developed for the extraction of caffeine in foods and beverages prior to its spectrophotometric determination. Ultrasound was used to accelerate the extraction of caffeine. Deep eutectic solvents (DES), prepared in an ultrasonic bath at 20-60 min for 60-80°C, were used as extraction solvents. The important experimental variables (pH, DES amount, temp...

Mechanistic study of selective absorption of NO in flue gas using EG-TBAB deep eutectic solvents.

The selective absorption of NO in flue gas has been investigated using a series of deep eutectic solvents (DESs) as novel denitrifying agents. The EG-TBAB DESs used in this work are composed of a hydrogen donor ethylene glycol (EG) and a parent salt tetrabutylammonium bromide (TBAB). Effects of DES composition (EG:TBAB molar ratio), operation temperature, residence time, and O2 concentration in the flue gas on denitrification performances of EG-TBAB DESs have been investigated. The highest denitrification e...

Study of naproxen in some aqueous solutions of choline-based deep eutectic solvents: Solubility measurements, volumetric and compressibility properties.

Naproxen (NAP) is a widely used drug for the treatment of pain and inflammatory conditions. However, the physicochemical information about properties such as solubility, apparent molar volume, and apparent molar isentropic compressibility for this drug is not abundant especially in the presence of deep eutectic solvents (DES) as a new class of green solvents to overcome the low solubility of drugs. In this work, the solubility of NAP is studied in the solutions containing some choline chloride (ChCl) based ...

Dispersive liquid-liquid microextraction based on solidification of deep eutectic solvent droplets for analysis of pesticides in farmer urine and plasma by gas chromatography-mass spectrometry.

A new disperser-less, centrifuge-less, ice-bath less and deep eutectic solvent-based solidification of organic droplets dispersive liquid-liquid microextraction performed in a laboratory-made extraction apparatus coupled with gas chromatography-mass spectrometry has been developed for the analysis of ten pesticides in plasma and urine samples. For this purpose, a glass tube containing a glass membrane filter was fabricated and a new synthesized deep eutectic solvent with density lighter than water was used ...

Deep eutectic solvents for redox biocatalysis.

Deep eutectic solvents (DES) are a class of neoteric solvents used in multiple applications amongst which biocatalytic processes. Due to its simple preparation, low cost and inherent biodegradable properties, its use as a non-volatile biocompatible co-solvent with both whole cells and isolated enzymes has displayed increased enzyme activity and stability translating to higher product conversions and a surprising higher enantioselectivity in a range of biotransformations. This review lays out the latest upda...

From batch to fed-batch and to continuous packed-bed reactors: Lipase-catalyzed esterifications in low viscous deep-eutectic-solvents with buffer as cosolvent.

This work explores for the first time the use of Deep Eutectic Solvents (DES) with phosphate buffer 100 mM pH 7 as cosolvent (10% v/v) in biocatalytic reactions in fed-batch and packed-bed bioreactors. The lipase-catalyzed esterification of glycerol and benzoic acid is studied, as it involves two substrates with different polarities (for which DES are needed). In the fed-batch bioreactor, the highest conversion (90%) was obtained at a substrate flow rate of 0.01 mL/min. The fed-batch operation increased...

Efficient extraction of flavonoids from Flos Sophorae Immaturus by tailored and sustainable deep eutectic solvent as green extraction media.

In the face of the many shortcomings of conventional organic solvents in the age of green chemistry, deep eutectic solvents (DESs) appear under the spotlight of natural product extraction because of its outstanding advantages. In this study, the extraction of six compounds from Flos Sophorae Immaturus (FSI) with DES-5 (choline chloride/1,4-butanediol) as its topgallant solvent was determined by screening nine DESs. After single factor test and BBD experiment, the optimum conditions of deep eutectic solvent-...

Growth of heterojunctions in Si-Ge alloy nanowires by altering AuGeSi eutectic composition using an approach based on thermal oxidation.

Understanding the growth mechanism of heterojunctions in silicon-germanium alloy (Si-Ge) nanowires is helpful for designing adequate physical properties in the material for device applications. We examine the formation of the heterojunction in low Ge-content Si-Ge nanowires by an approach of thermal oxidation, which produces an atomically abrupt interface with an obvious concentration change. Forming heterojunctions in Si-Ge nanowires by this approach involves more complicated reaction routes than direct gr...

Organolithium Initiated Polymerization of Olefins in Deep Eutectic Solvents under Aerobic Conditions. Sustainable Route to Homopolymers, Random Copolymers and Block Copolymers.

Despite their ubiquitous presence in synthesis, the use of polar organolithium reagents under environmentally benign conditions constitutes one of the greatest challenges in sustainable chemistry. Their high reactivity imposes the use of severely restrictive protocols (e.g., moisture- and oxygen-free toxic organic solvents, inert atmospheres, low temperatures, etc.). Making inroads towards meeting this challenge, here we establish a new air- and moisture-compatible organolithium-mediated methodology for the...

Combination of a modified quick, easy, cheap, efficient, rugged, and safe extraction method with a deep eutectic solvent-based microwave assisted-dispersive liquid-liquid microextraction; Application in extraction and preconcentration of multiclass pesticide residues in tomato samples.

In this study, a new two-step extraction procedure based on the combination of a modified quick, easy, cheap, effective, rugged, and safe extraction method with a deep eutectic solvent-based microwave-assisted dispersive liquid-liquid microextraction has been developed for the extraction of multiclass pesticides in tomato samples before their analysis by gas chromatography-flame ionization detection. In this method, initially, an aliquot of tomato is crushed and diluted with deionized water. The mixture is ...

Formation mechanisms of Caprolactam-tetraalkyl ammonium halide deep eutectic and its hydrate.

Deep eutectic solvents (DES) are generally composed of two or three cheap and safe components that are associated with each other via hydrogen bonds. The formation Caprolactam (CPL)-tetraalkyl ammonium halide (TAAX) DES and its hydrate were investigated using React IR. TAAX was introduced to CPL in the molten state at 353.15 K, the intermolecular H-N-C=O⋯H-N-C=O hydrogen bonds (CPL dimer) transfer to X⋯H-N-C=O (CPL-TAAX DES). When water was added to CPL-TAAX DES, intermolecular X⋯H-N-C=O⋯H-O-H hyd...

Ternary deep eutectic solvents for effective biomass deconstruction at high solids and low enzyme loadings.

Ternary deep eutectic solvents (DESs) were developed to enable rapid and high-solid biomass pretreatment as well as concentrated sugar hydrolysate production. Six ternary DESs constituted choline chloride (ChCl) or guanidine hydrochloride (GH) as a hydrogen bond acceptor (HBA), ethylene glycol (EG) or propylene glycol (PG) or glycerin (GLY) as a polyol-based hydrogen bond donor (HBD), and p-toluenesulfonic acid (PTSA) as an acidic HBD. GH-EG-PTSA was the most effective, evidenced by 79% xylan and 82% lignin...

Highly effective and safe intermediate based on deep eutectic medium for carrier less-three phase hollow fiber microextraction of antiarrhythmic agents in complex matrices.

For the first time, three phase hollow fiber liquid phase microextraction using an influential, and green middle phase comprised a new relatively-hydrophobic deep eutectic solvent (three-phase HF-LPME-DES) was developed for trace analyses of antiarrhythmic drugs in biological and environmental samples. The extraction solvent was easily synthesized by mixing the green and cheap raw materials, namely choline chloride and 1-phenylethanol (ChCl: Ph-ETOH), in the ambient temperature. Good compatibility to pores ...

A clean approach for functionalized carbon nanotubes by deep eutectic solvents and their performance in the adsorption of methyl orange from aqueous solution.

In this study two deep eutectic solvents (DESs) were prepared using ethylene glycol (EG) and two different ammonium-based salts. The potential of these DESs as novel agents for CNTs functionalization was examined by performing a comprehensive characterization study to identify the changes developing after the functionalization process. The impact of DESs was obvious by increasing the surface area of CNTs to reach 197.8 (m/g), and by adding new functional groups to CNTs surface without causing any damage to ...

Multifunctional hyaluronate - Nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications.

Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a...

The Molecularly Heterogeneous Structure of a Non-Ionic Deep Eutectic Solvent Composed of N-Methylacetamide and Lauric Acid.

Deep eutectic solvents (DES) are a new class of designer solvents with a wide range of possible applications. DESs are typically made from an ionic compound and a hydrogen bond donor, but lately DESs made of non-ionic compounds with interesting properties have started to appear. This study focuses on describing the structure, dynamics, and interactions of a non-ionic DES composed of N-methylacetamide and lauric acid. Linear IR and time-resolved IR experiments show that LA-NMA DES is the result of hydrogen b...

Deep eutectic solvents based on choline cation - Physicochemical properties and influence on enzymatic reaction with β-galactosidase.

In presented study analysis of physicochemical properties of deep eutectic solvents (DESs) and their usefulness as an element of reaction medium for β-galactosidase from Kluyveromyces lactis was conducted. Analyzed DESs were based on choline salt derivatives: choline chloride, choline acetate and hydrogen bond-donors (HBD) such as: glycerol, ethylene glycol, urea, thiourea and levulinic acid. Results showed that reaction medium with appropriate amount of DES based on choline acetate had beneficial effect o...

Water absorption by deep eutectic solvents.

Deep eutectic solvents (DESs) are one type of green solvents. Most of the DESs could absorb water from air. However, even a trace amount of water can affect the chemical structure and physical properties of DESs. To date, no study has been reported on the hygroscopicity of DESs. Consequently, in this study, a comprehensive investigation was performed on the capacity, kinetics, mechanism, and furthermore the dynamic process (by PCMW2D-COS IR spectra) of atmospheric water absorption from air by DESs. The resu...

Effect of functional groups in acid constituent of deep eutectic solvent for extraction of reactive lignin.

In this study, acidic deep eutectic solvents (DES) synthesized from various organic carboxylic acid hydrogen bond donors were applied to lignocellulosic oil palm empty fruit bunch (EFB) pretreatment. The influence of functional group types on acid and their molar ratios with hydrogen bond acceptor on lignin extraction were evaluated. The result showed presence of hydroxyl group and short alkyl chain enhanced biomass fractionation and lignin extraction. Choline chloride:lactic acid (CC-LA) with the ratio of ...


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