PubMed Journals Articles About "Step Pharma" RSS

21:02 EST 16th February 2020 | BioPortfolio

Step Pharma PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Step Pharma articles that have been published worldwide.

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Showing "Step Pharma" PubMed Articles 1–25 of 3,700+


Participants of Pharma-sponsored research are exposed to risks, benefits, and uncertainties that do not occur in other forms of clinical studies. Ethics committees represent the subjects' first line of protection. This responsibility begins with the study review and ends after all study subjects finish the intervention. The objective of this paper is to review the most common controversial issues found in Pharma-sponsored studies. Potential solutions are proposed to prevent or resolve the polemical aspects....

The Art of Virtualizing Pharma R&D.

Effects of Moving the United States Medical Licensing Examination Step 1 After Core Clerkships on Step 2 Clinical Knowledge Performance.

To investigate the effect of a change in USMLE Step 1 timing on Step 2 Clinical Knowledge (CK) scores, the effect of lag-time on Step 2 CK performance, and the relationship of incoming MCAT score to Step 2 CK performance pre- and post-change.

Will We Have a Drug for Alzheimer's Disease by 2030? The View From Pharma.

Calculated Decisions: Step-by-Step Approach to Febrile Infants

The Step-by-Step approach to febrile infants identifies febrile infants aged ≤ 90 days who are at low risk for invasive bacterial infections.

Pharmaceutical Ethics and Grassroots Activism in the United States: A Social History Perspective.

Women's health activists laid the groundwork for passage of the law that created the U.S. Food and Drug Administration in 1906. The pharmaceutical and food industries fought regulatory reforms then and continue to do so now. We examine public health activism in the Progressive Era, the postwar era and the present day. The women's health movement began in the 1960s, and criticized both the pharmaceutical industry and the medical establishment. In the 1990s, patient advocacy groups began accepting industry fu...

Can real-world evidence save pharma US$1 billion per year? A framework for an integrated evidence generation strategy.

A step in the right direction: Lessons learned from the USMLE Step 1.

Every year, thousands of medical students in the United States and internationally take the USMLE Step 1 exam, just as their mentors did before them. Numerous commentators - physicians and students - have argued that there are problems with the USMLE Step 1 exam, including that it devalues clinically relevant educational content not tested on Step 1, it has negative consequences for student mental health, it perpetuates the misuse of race in clinical diagnosis, and dependence on Step 1 scores may hinder eff...

Versatile and Valuable Utilization of Amidohydrolase L-Glutaminase in Pharma and Food industries: A Review.

L-Glutaminase has versatile applications in Pharma and food industries. In pharmaceutical industry, L-Glutaminase can used as anti-oxidant and anti-cancer agent to treat Acute Lymphocytic Leukaemia (ALL). Whereas, in food industry L-Glutaminase is used for acrylamide degradation, theanine production, flavour enhancer, soy sauce and many. The other applications include nitrogen metabolism and its use as biosensor in hybridoma technology. Both intra-cellular and extra-cellular L-Glutaminases from wide range o...

Step length and grade effects on energy absorption and impact attenuation in running.

We sought to examine the effect of step length manipulation on energy absorption and impact attenuation during graded running. Nineteen runners (10F, 9M) ran on an instrumented treadmill at three step lengths (preferred and ±10% preferred) at each of five grades (0°, ±5°, and ±10°) while 3D motion data were captured. Speed was held constant at 3.33 m/s and step length was manipulated by syncing cadence to a metronome. Manipulating step length altered energy absorption ( ≤ 0.002) and impact att...

Prone Position during Mechanical Ventilation - Step by Step.

The Acute Respiratory Distress Syndrome is still a very severe condition in intensive care patients. Prone positioning is known to improve outcome in patients with moderate to severe ARDS. Therefore proning in these patients is nowadays to be regarded as a standard of care. The risks of proning are reasonably low - if proning is done correctly. Therefore a method of proning in a step-by-step-approach is shown in this article.

Can We Strengthen Regional Cooperation of Central and East European Countries within European Programmes in the Field of Medicinal and Pharma Biotechnologies? Reminiscence from the European Workshop, Bratislava, Slovakia 3-4 June 2019.

Two-step accelerating freezing protocol yields a better motility, membranes and DNA integrities of thawed ram sperm than three-steps freezing protocols.

The present study compares a protocol that mimics freezing of ram semen in static nitrogen vapor with two protocols with an initial low cooling rate in the first step, followed by higher cooling rates where ice nucleation occurs. Semen ejaculates, obtained from twelve adults rams, were diluted with TEST-based extender and frozen with either Protocol 1 (three-step decelerating cooling): from +5 °C to -35 °C (40 °C/min), from -35 °C to -65 °C (17 °C/min), and then from -65 °C to -85 °C (3 °C...

The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?

Ultrasound-Guided Access and Dilation for Percutaneous Nephrolithotomy (PCNL) in the Supine Position: a step-by-step approach.

Ultrasound guidance for percutaneous nephrolithotomy (PCNL) has gained acceptance amongst urologists given its numerous advantages over fluoroscopy. While traditionally performed in the prone position, this video demonstrates a step-by-step approach to performing PCNL in the supine position, solely under ultrasound guidance.

Eight steps for narrowing the maternal health disparity gap: Step-by-step plan to reduce racial and ethnic disparities in care.

The Value of Numerical USMLE Step 1 Scores in Radiology Resident Selection.

In response to a recent proposal to change scoring on the United States Medical Licensing (USMLE) Step 1 exam to pass/fail, we sought to determine the value of numerical Step 1 scores in predicting success in our radiology residency program.

Monosynaptic tracing: a step-by-step protocol.

Monosynaptic tracing using deletion-mutant rabies virus allows whole-brain mapping of neurons that are directly presynaptic to a targeted population of neurons. The most common and robust way of implementing it is to use Cre mouse lines in combination with Cre-dependent adeno-associated viral vectors for expression of the required genes in the targeted neurons before subsequent injection of the rabies virus. Here we present a step-by-step protocol for performing such experiments using first-generation (ΔG)...

Effect of Atomic Corrugation on Adhesion and Friction - A Model Study with Graphene Step Edges.

This letter reports that the atomic corrugation of the surface can affect nanoscale interfacial adhesion and friction differently. Both atomic force microscopy (AFM) and molecular dynamics (MD) simulations showed that the adhesion force needed to separate a silica tip from a graphene step edge increases as the side wall of the tip approaches the step edge when the tip is on the lower terrace, and decreases as the tip is ascending or descending the step edge. However, the friction force measured with the sam...

Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?

[This corrects the article DOI: 10.1371/journal.pone.0220791.].

Step-Edge-Induced Anisotropic Chiral Spin Coupling in Ultrathin Magnetic Films.

Step edges represent a local break of lateral symmetry in ultrathin magnetic films. In our experiments, we investigate the spin coupling across atomic step edges on Fe/W(110) by means of spin-polarized scanning tunneling microscopy and spectroscopy. Local modifications of the spin texture toward step edges separating double from single layer areas are observed, and selection rules indicate a chiral spin coupling that significantly changes with the propagation along the [11[over ¯]0] or the [001] crystallog...

Laparoscopic ureteroplasty with buccal mucosa graft for long proximal ureteral stenosis: A step by step video.

Discussion: Spare Roof Technique: A New Technique for Hump Removal-The Step-by-Step Guide.

In-office Transperineal Prostate Biopsy Using Biplanar Ultrasound Guidance: a Step-by-Step Guide.

To provide a step-by-step guide for performing in-office transperineal prostate biopsy using biplanar ultrasound guidance.

Single-Step Method for Pull-Type Gastrostomy Tube Placement.

Single-step pull-type gastrostomy tube (PGT) placement is a method involving gastric puncture with a curved 18-gauge trocar needle allowing retrograde cannulation of the gastroesophageal junction without use of a sheath or snare. This retrospective review of 102 patients who underwent single-step PGT placement demonstrated 91% success in advancing the wire up the esophagus using only the curved trocar. Successful placement of a gastrostomy tube was 100%. Two major and 2 minor complications occurred within 3...

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