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PubMed Journals Articles About "Stretch Shoulder Stretch Gait" RSS

18:17 EDT 21st September 2019 | BioPortfolio

Stretch Shoulder Stretch Gait PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Stretch Shoulder Stretch Gait articles that have been published worldwide.

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Showing "Stretch Shoulder Stretch Gait" PubMed Articles 1–25 of 1,100+

miR-486 is modulated by stretch and increases ventricular growth.

Perturbations in biomechanical stimuli during cardiac development contribute to congenital cardiac defects such as Hypoplastic Left Heart Syndrome (HLHS). This study sought to identify stretch-responsive pathways involved in cardiac development. microRNA (miRNA)-Sequencing identified miR-486 as being increased in cardiomyocytes exposed to cyclic stretch in vitro (63%, p


Cyclooxygenase inhibition does not impact the pressor response during static or dynamic mechanoreflex activation in healthy decerebrate rats.

Passive limb movement or limb muscle stretch in humans and animals are common experimental strategies used to investigate activation of the muscle mechanoreflex independent of contraction-induced metabolite production. Cyclooxygenase (COX) metabolites, however, are produced by skeletal muscle stretch in vitro and have been found to impact various models of mechanoreflex activation. Whether COX metabolites influence the decerebrate rat triceps surae muscle stretch mechanoreflex model remains unknown. We exam...

Bond stretch isomerism in Be driven by the Renner-Teller effect.

We investigate the underlying principle behind the occurrence of bond stretch isomerism in Be32-, which has not been revealed yet. Various computational studies of the different isomers are carried out at the complete active space self-consistent field (CASSCF) level of theory in addition to the B3LYP level in conjunction with the 6-311++G(d) basis set. The potential energy surfaces linking the different isomers through transition states and conical intersections are investigated at the CASSCF level, connec...


Mechanical stretch enhances sex steroidogenesis in CC Skeletal Muscle Cells.

Skeletal muscle contains estrogens and estrogen synthesis-related enzymes. However, it has not been reported whether myoblasts cultured in vitro also express these enzymes. The purpose of the current study was to address these issues and to explore the effects of mechanical stretch on the enzyme system. The in vitro cultured CC mouse myoblasts were divided into the control, stretch, testosterone and stretch plus testosterone groups. Cells in the stretch and stretch plus testosterone groups were mechanically...

Cyclic tensile stress promotes osteogenic differentiation of adipose stem cells via ERK and p38 pathways.

The present study aimed to elucidate whether extracellular signal-regulated kinases 1/2 (ERK1/2) and p38 mitogen-activated protein kinases pathways participate in the transduction of mechanical stretch exerted on adipose stem cells (ASCs) into intracellular osteogenic signals, and if so whether both pathways have time-dependent feature. Rat ASCs were cultured in osteogenic medium for 72 h and assigned into three sets, namely ERK1/2 inhibitor treated set, p38 inhibitor treated set, and the control set. Aft...

Stretch-shortening cycle exercise produces acute and prolonged impairments on endurance performance: is the peripheral fatigue a single answer?

This study aimed to verify the acute and prolonged effects of stretch-shortening cycle exercise (SSC) on performance and neuromuscular function following a 4-km cycling time trial (4-km TT).

Excessive short-latency stretch reflexes in the calf muscles do not cause postural instability in patients with hereditary spastic paraplegia.

To identify the role of hyperexcitable short-latency stretch reflexes (SLRs) on balance control in people with hereditary spastic paraplegia (PwHSP).

Resonant Frequency Skin Stretch for Wearable Haptics.

Resonant frequency skin stretch uses cyclic lateral skin stretches matching the skin's resonant frequency to create highly noticeable stimuli, signifying a new approach for wearable haptic stimulation. Three experiments were performed to explore biomechanical and perceptual aspects of resonant frequency skin stretch. In the first experiment, effective skin resonant frequencies were quantified at the forearm, shank, and foot. In the second experiment, perceived haptic stimuli were characterized for skin stre...

MMP12 preferentially attenuates axial stiffening of aging arteries.

Arterial stiffening is a hallmark of aging, but how aging affects the arterial response to pressure is still not completely understood, especially with regard to specific matrix metalloproteinases (MMPs). Here, we used pressure myography of carotid arteries from C57BL/6 mice to study the effects of age and MMP12, a major arterial elastase, on arterial biomechanics. Aging from 2 to 24 months leads to both circumferential and axial stiffening with stretch, and these changes are associated with an increased wa...

Lamin A/C negatively regulated by miR-124-3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats.

Apoptosis of vascular smooth muscle cells (VSMCs) influenced by abnormal cyclic stretch is crucial for vascular remodeling during hypertension. Lamin A/C, a nuclear envelope protein, is mechano-responsive, but the role of lamin A/C in VSMC apoptosis is still unclear.

Self-Assembly and Biogenesis of Cellular Membrane is Dictated by Membrane Stretch and Composition.

The cell plasma membrane is a highly dynamic organelle governing a wide range of cellular activities including ion transport, secretion, cell division, growth and development. The fundamental process involved in the addition of new membrane to preexisting plasma membrane however, is unclear. Here we report using biophysical, morphological, biochemical and molecular dynamic simulations, the selective incorporation of proteins and lipids from the cytosol into the cell plasma membrane dictated by membrane stre...

Periodized versus Non-periodized Stretch Training on Gymnasts Flexibility and Performance.

Static stretching (SS) can increase joint range of motion (ROM), due to neural, morphological, and physio-psychological factors. Periodized training programs (PD) (e. g., strength, power) are adopted to induce greater adaptations while avoiding overtraining. However, the effectiveness of periodized stretch training adaptations are unknown. Therefore, the objective of this study was to compare the effects of periodized and non-periodized (NP) stretching programs on flexibility, hamstrings stiffness and mus...

Lamellipodium tip actin barbed ends serve as a force sensor.

Cells change direction of migration by sensing rigidity of environment and traction force, yet its underlying mechanism is unclear. Here we show that tip actin barbed ends serve as an active 'force sensor' at the leading edge. We established a method to visualize intracellular single-molecule fluorescent actin through an elastic culture substrate. We found that immediately after cell edge stretch, actin assembly increased specifically at the lamellipodium tip. The rate of actin assembly increased with incre...

Acquisition of a Simple Motor Skill: Task-Dependent Adaptation and Long-Term Changes in the Human Soleus Stretch Reflex.

Changing the H-reflex through operant conditioning leads to CNS multi-site plasticity and can affect previously learned skills. In order to further understand the mechanisms of this plasticity, we operantly conditioned the initial (M1) component of the soleus stretch reflex. Unlike the H-reflex, the stretch reflex is affected by fusimotor control, comprises several bursts of activity resulting from temporally dispersed afferent inputs, and may activate spinal motoneurons via several different spinal and sup...

Microrna-29a Involvement in Phenotypic Transformation of Venous Smooth Muscle Cells via Tet1 in Response to Mechanical Cyclic Stretch.

Mechanical stimuli play an important role in vein graft restenosis and the abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) are pathological processes contributing to this disorder. Here, based on previous high throughput sequencing data from vein grafts, miR-29a-3p and its target, the role of Ten-eleven translocation methylcytosinedioxygenase 1 (TET1) in phenotypic transformation of VSMCs induced by mechanical stretch was investigated. Vein grafts were generated by using the 'cu...

Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway.

To explore the role and mechanism of mechano-growth factor (MGF) in cyclic stretch (CS)-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells (hPDLCs).

A 14-bp stretch plays a critical role in regulating gene expression from β-tubulin promoters of basidiomycetes.

Cis-acting elements play a vital role in regulation of transcription initiation. Several cis-acting elements have been identified in filamentous fungi; however, the fundamental requirements for basic promoter function in basidiomycetes are obscure. In this study, core elements in β-tubulin promoters of basidiomycetes were functionally characterized. Using transient transformation in Ceriporiopsis subvermispora as a promoter assay, we found that a 14-bp region (β-tubulin core promoter element, BCE), as wel...

Micromechanically-motivated analysis of fibrous tissue.

Collagen fibers are the main load bearing component in fibrous tissues. Systematic analyses of their structure and orientation are thus crucial for the development of material models that enable to predict the mechanical tissue response. To this end, biaxial tests at different stretch ratios were performed on two tissue samples of the medial layer extracted from a human aorta. The tissues were loaded in the circumferential and axial directions simultaneously. We develop here a micromechanical model which is...

The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating.

The cardiac mechanosensitive BK (Slo1) channels are gated by Ca, voltage and membrane stretch. The neuropeptide GsMTx4 is a selective inhibitor of mechanosensitive (MS) channels. It has been reported to suppress stretch-induced cardiac fibrillation in the heart, but the mechanism underlying the specificity and even the targeting channel(s) in the heart remain elusive. Here we report that GsMTx4 inhibits a stretch-activated BK channel (SAKcaC) in heart through a modulation specific to mechano-gating. We show...

Peptides derived from a short stretch of diphtheria toxin bind to heparin-binding epidermal growth factor-like growth factor.

Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) is the receptor for diphtheria toxin (DT). Mutated or truncated, non-toxic DT has been used earlier for HB-EGF-targeted drug delivery and to modulate HB-EGF signaling. In the present work, we have synthesized a peptide corresponding to a 26 amino acid long stretch of the receptor-binding domain of DT. This region of DT makes multiple contacts with HB-EGF and has residues critical for binding to HB-EGF. We show that this peptide and two of its...

Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition.

Phospholipase Cβ (PLCβ) enzymes regulate second messenger production following the activation of G protein-coupled receptors (GPCRs). Under basal conditions, these enzymes are maintained in an autoinhibited state by multiple elements, including an insertion within the catalytic domain known as the X-Y linker. Although the PLCβ X-Y linker is variable in sequence and length, its C-terminus is conserved and features an acidic stretch, followed by a short helix. This helix interacts with residues near the ac...

Critical-Layer Structures and Mechanisms in Elastoinertial Turbulence.

Simulations of elastoinertial turbulence (EIT) of a polymer solution at low Reynolds number are shown to display localized polymer stretch fluctuations. These are very similar to structures arising from linear stability (Tollmien-Schlichting modes) and resolvent analyses, i.e., critical-layer structures localized where the mean fluid velocity equals the wave speed. Computations of self-sustained nonlinear Tollmien-Schlichting waves reveal that the critical layer exhibits stagnation points that generate shee...

A myosin-based mechanism for stretch activation and its possible role revealed by varying phosphate concentration in fast and slow mouse skeletal muscle fibers.

Stretch activation (SA) is a delayed increase in force following a rapid muscle length increase. SA is best known for its role in asynchronous insect flight muscle where it has replaced calcium's typical role of modulating muscle force levels during a contraction cycle. SA also occurs in mammalian skeletal muscle, but has previously been thought to be too low in magnitude, relative to calcium-activated (CA) force, to be a significant contributor to force generation during locomotion. To test this suppositio...

Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy.

Cardiac remodeling is induced by mechanical or humoral stress causing pathological changes to the heart. Here, we aimed at identifying the role of differentially regulated genes upon dynamic mechanical stretch. Microarray of dynamic stretch induced neonatal rat ventricular cardiomyocytes (NRVCMs) discovered Rho family GTPase 1 (Rnd1) as one of the significantly upregulated genes, a cardiac role of which is not known yet. Rnd1 was consistently upregulated in NRVCMs after dynamic stretch or phenylephrine (PE)...

Spastic dystonia in stroke subjects: prevalence and features of the neglected phenomenon of the upper motor neuron syndrome.

Spastic dystonia is one of the positive phenomena of the upper motor neuron syndrome (UMNS). It is characterised by the inability to relax a muscle leading to a spontaneous, although stretch-sensitive, tonic contraction. Although spastic dystonia is a recognized cause of muscle hypertonia, its prevalence among hypertonic muscles of stroke subjects has never been investigated. Differently from spasticity, which is an exaggerated stretch reflex, spastic dystonia is viewed as an efferent phenomenon, due to an ...


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