PubMed Journals Articles About "Subcutaneous Injection Luer Syringe DERMOJET Syringe Without Needle" RSS

05:52 EDT 21st August 2018 | BioPortfolio

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Showing "Subcutaneous injection luer syringe DERMOJET syringe without needle" PubMed Articles 1–25 of 3,200+

Should sterile needle and syringe wastage be included within individual-level needle and syringe coverage measures?

Evaluation of the use of a needle-free injection syringe as a cause of non-specific reactions in the intradermal tuberculin test used for the diagnosis of bovine tuberculosis.

The objective of the study was to elucidate whether the use of the needle-free Dermojet syringe, which is based on a high pressure inoculation and is used to inject tuberculin in cattle in several countries, may, in itself, cause skin reactions that can be interpreted as positive reactions to the intradermal tests that are not, in fact, related to the real infection status of the animals. Forty-four cattle from an officially tuberculosis-free (OTF) herd were selected, and four single intradermal tuberculin ...

Sterile Basics of Compounding: Relationship Between Syringe Size and Dosing Accuracy.

The purpose of this study was to investigate the accuracy and reproducibility of a 2-mL volume injection using a 3-mL and 10-mL syringe with pharmacy student compounders. An exercise was designed to assess each student's accuracy in compounding a sterile preparation with the correct 4-mg strength using a 3-mL and 10-mL syringe. The average ondansetron dose when compounded with the 3-mL syringe was 4.03 mg (standard deviation ± 0.45 mg), which was not statistically significantly different than the intended ...

Measuring individual-level needle and syringe coverage among people who inject drugs in Myanmar.

Myanmar has prioritised people who inject drugs (PWID) as a key population for HIV mitigation efforts, with targets for needle and syringe distribution set at a population level. However, individual-level coverage, defined as the percentage of an individual's injecting episodes covered by a sterile syringe, is a more sensitive measure of intervention coverage. We sought to examine individual-level coverage in a sample of PWID in Myanmar.

Syringe sharing among people who inject drugs in London, Canada.

London, Ontario, is facing an outbreak of HIV among people who inject drugs (PWID), as well as persistently high levels of hepatitis C virus (HCV). Syringe sharing is the primary driver of HIV and HCV transmission risks among PWID, however, little is known about factors contributing to syringe sharing in this setting. Therefore, we sought to characterize syringe sharing and its correlates among London PWID.

Predicting pharmacy syringe sales to people who inject drugs: Policy, practice and perceptions.

Pharmacies have much to contribute to the health of people who inject drugs (PWID) and to community efforts in HIV and hepatitis C (HCV) prevention through syringe access. However, little is known about what predicts pharmacy syringe sales without a prescription.

Similar Pharmacokinetics of the Adalimumab (Humira) Biosimilar BI 695501 Whether Administered via Subcutaneous Autoinjector or Prefilled Syringe (VOLTAIRE-AI and VOLTAIRE-TAI): Phase 1, Randomized, Open-Label, Parallel-Group Trials.

BI 695501 has shown similar efficacy, safety, and immunogenicity to the adalimumab reference product, Humira. We present two phase 1 studies comparing the pharmacokinetics, safety, and immunogenicity of BI 695501 delivered via autoinjector (AI) vs. prefilled syringe (PFS).

Knowledge of hepatitis C status moderates the relationship between history of drug treatment and sterile syringe use.

High-risk injection related behavior including use of non-sterile syringes is associated with negative health outcomes among people who inject drugs (PWID). Drug treatment programs have been reported to curb hepatitis C (HCV) transmission. This study aims to assess the role of drug treatment programs and knowledge of HCV status, and how they influence current injection-related risk. Data were collected in 2012 by the New Orleans arm of the CDC funded National HIV Behavioral Surveillance. Respondent driven s...

Federal funding for syringe exchange in the US: Explaining a long-term policy failure.

The United States prohibited federal funding for syringe exchange programs for people who inject drugs nearly continuously from 1988 to 2015, despite growing scientific evidence, diminishing AIDS-related controversy, and tens of thousands of deaths from injection-related AIDS. This study investigates the political and institutional bases of this long-term failure to support lifesaving public policy.

Safe and unsafe spaces: Non-fatal overdose, arrest, and receptive syringe sharing among people who inject drugs in public and semi-public spaces in Baltimore City.

The spaces in which drug use occurs constitutes a key aspect of the "risk environment" of people who inject drugs (PWID). We aimed to add nuance to the characterization of "safe" and "unsafe" spaces in PWID's environments to further understand how these spaces amplify the risk of morbidities associated with injection drug use. PWID were recruited through the Baltimore City syringe service program and through peer referral. Participants completed a socio-behavioral survey. Multivariable logistic regression w...

Pneumatic dart delivery of tulathromycin in calves results in lower antimicrobial concentrations and increased biomarkers of stress and injection site inflammation compared to subcutaneous injection.

Remote drug delivery (RDD) using pneumatic darts has become more prevalent in situations where cattle handling facilities are not available. The objective of this study was to compare the effect of pneumatic dart delivery and subcutaneous injection of tulathromycin on plasma pharmacokinetics and biomarkers of inflammation, stress, and muscle injury in calves. Twenty-three castrated-male Holstein calves, approximately 10 months of age with an average weight of 378 ± 6.49 kg, were randomly assigned to one of...

Arterial blood gas sampling: using a safety and pre-heparinised syringe.

Taking arterial blood gases (ABG) is an essential part of the diagnosis and management of critically ill patients. An arterial blood sample is collected from an artery, primarily to determine the ABGs. Health professionals should only undertake this if the procedure is in the legal scope of practice for their profession in their country, and they have demonstrated skilled, proficient, safe practice after formal training. Blood samples can be obtained via an arterial catheter inserted into an artery or percu...

Patterns of Peer Distribution of Injecting Equipment at an Authorized Distribution Site in Sydney, Australia.

Extended distribution refers to the practice whereby people who inject drugs pass on sterile injecting equipment to their networks and can be a means to access people who inject drugs who do not attend state-sanctioned needle and syringe programs. While it is legal, to possess a sterile syringe for the purpose of injecting drugs in New South Wales, Australia, it is a criminal offence to pass this equipment on for others to use. In 2013 a pilot project was established to trial the authorization of "extended"...

Bioequivalence of Canakinumab Injected Subcutaneously via an Autoinjector Device or a Prefilled Safety Syringe Device in Healthy Subjects.

Canakinumab, a high-affinity human anti-interleukin-1β monoclonal antibody, is being used for the treatment of a broad spectrum of inflammatory diseases. This phase 1 study compared the relative bioavailability of a single dose of subcutaneous canakinumab either self-administered with an autoinjector (AI) or administered by a health care professional (HCP) with a prefilled safety syringe (SS) in healthy subjects. The study enrolled 80 subjects randomized 1:1 to receive 150 mg/mL of a liquid formulation of...

Stability study of 18Ffludeoxyglucose and 18Ffluorocholine in different medical devices for intravenous administration.

[18F]-radiopharmaceuticals registered as ready-to-use drugs are prepared in multi-dose flasks. When the change of packaging must be made extemporaneously for the preparation of patient unit doses in a syringe or cartridge, this is under the responsibility of radiopharmacists. As drug quality in medical devices (syringe or cartridge) is not evaluated during the marketing authorization of such radiopharmaceuticals, an evaluation of drug stability in such devices seems interesting. In addition, if there are di...

Epinephrine auto-injector needle lengths can both subcutaneous and periosteal/intraosseous injection be avoided?

Administration of epinephrine should be intramuscularly in the anterolateral aspect of the thigh. The length of the epinephrine autoinjector, EAI, needle should assure intramuscular injection.

Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery.

Intracerebral implantation of cell suspensions is finding its clinical translation with encouraging results in patients with stroke. However, the survival of cells in the brain remains poor. Although the biological potential of neural stem cells (NSCs) is widely documented, the biomechanical effects of delivering cells through a syringe-needle remain poorly understood. We here detailed the biomechanical forces (pressure, shear stress) that cells are exposed to during ejection through different sized needles...

Syringe Administration of Epinephrine by Emergency Medical Technicians for Anaphylaxis.

In recent years, the costs of epinephrine autoinjectors (EAIs) in the United States have risen substantially. King County Emergency Medical Services implemented the "Check and Inject" program to replace EAIs by teaching emergency medical technicians (EMTs) to manually aspirate epinephrine from a single-use 1 mg/mL epinephrine vial using a needle and syringe followed by prehospital intramuscular administration of the correct adult or pediatric dose of epinephrine for anaphylaxis or serious allergic reaction...

Factors associated with time between using a drug and injection initiation among people who inject drugs in Kermanshah, Iran.

Background The transition from non-injection to injection drug use dramatically increases the risk of transmitting HIV and other blood borne infections including hepatitis B virus (HBV) and hepatitis C virus (HCV). The aim of this study was to explore factors associated with the transition from first illicit drug use to first injection among drug users. Methods Using snowball sampling and convenience sampling through needle and syringe programmes (NSPs), we recruited 500 people who inject drugs (PWID) in Ke...

A miniaturized sorbent phase-based extraction device in the form of syringe filter holder using molecularly imprinted polymer as sorbent and its application to extract benzophenones.

The molecularly imprinted polymer using 2,4-dihydroxybenzophenone as the template (DHBP-MIP) was synthesized via sacrificial support method. The DHBP-MIP was demonstrated to possess good adsorption capacity and selectivity towards benzophenones. Moreover, a miniaturized sorbent phase-based extraction device in the form of syringe filter holder using DHBP-MIP as the sorbent was proposed, and named as μ-SPE-SFH-MIP device. The μ-SPE-SFH-MIP device consisted of a reusable syringe filter holder, flexible amou...

The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review.

A continuous subcutaneous infusion (CSCI) is an effective method of multiple drug administration commonly encountered in end of life care when the oral route is compromised. At present, current practice is to limit syringe driver infusion time to a maximum of 24 hours as dictated by available chemical stability data. However, the ability to deliver prescribed medication by a CSCI over 48 hours may have numerous benefits in both patient care and health service resource utilisation.

Public support for safe consumption sites and syringe services programs to combat the opioid epidemic.

We examine Americans' support for two evidence-based harm reduction strategies - safe consumption sites and syringe exchange programs - and their attitudes about individuals who use opioids. We conducted a web-based survey of a nationally representative sample of U.S. adults in July-August 2017 (N = 1004). We measured respondents' support for legalizing safe consumption sites and syringe services programs in their communities and their attitudes toward people who use opioids. We used ordered logistic re...

Non-Luer butterfly needle with one-way valve for epidural blood patch: impact on blood clotting.

Sweeping of adsorbed therapeutic protein on prefillable syringes promotes micron aggregate generation.

This study evaluated how differences in the surface properties of prefillable syringe (PFS) barrels and in-solution sampling methods affect micron aggregates and protein adsorption levels. Three syringe types [glass barrel with silicone oil coating (GLS/so+), glass barrel without silicone oil coating (GLS/so-) and cyclo-olefin polymer (COP) barrel syringes] were tested with three therapeutic proteins (adalimumab, etanercept, and infliximab) using two sampling methods (aspiration or ejection). After quiescen...

Packed hybrids of gold nanoparticles and layered double hydroxide nanosheets for microextraction of triazine herbicides from maize.

This work describes a nanohybrid material consisting of gold nanoparticles (AuNPs) and nanosheets of layered double hydroxides (NLDHs) of Mg(II) and Al(III). Mono-disperse AuNPs were immobilized on the surface of the LDHs via Au-O bonding. The nanohybrid sorbent was packed in an organic filter along with a syringe and applied to the microextraction of triazine herbicides with the help of an injection pump. The collected hexane eluate was concentrated and directly injected into a HPLC column for quantificati...

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