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PubMed Journals Articles About "Synergistic Antibiofilm Activity Antimicrobial Peptide Against Carbapenem Resistant" RSS

10:13 EDT 20th June 2019 | BioPortfolio

Synergistic Antibiofilm Activity Antimicrobial Peptide Against Carbapenem Resistant PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Synergistic Antibiofilm Activity Antimicrobial Peptide Against Carbapenem Resistant articles that have been published worldwide.

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Showing "Synergistic antibiofilm activity antimicrobial peptide against carbapenem resistant" PubMed Articles 1–25 of 23,000+

Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas aeruginosa.

In the search for new antimicrobial molecules, antimicrobial peptides (AMPs) offer a viable alternative to conventional antibiotics, as they physically disrupt the bacterial membranes, leading to membrane disruption and eventually cell death. In particular, the group of linear α-helical cationic peptides has attracted increasing research and clinical interest. The AMP P5 has been previously designed as a cationic linear α-helical sequence, being its antimicrobial and hemolytic properties also evaluated. I...


In vitro activity of eravacycline in combination with colistin against carbapenem-resistant A. baumannii isolates.

The synergistic activity of eravacycline in combination with colistin on carbapenem-resistant A. baumannii (CRAB) isolates was evaluated in this study. Minimum inhibitory concentrations (MICs) of eravacycline and colistin were determined by the broth microdilution method. MICs values ranged between 1 to 4 mg and 0.5 to 256 mg l for eravacycline and colistin, respectively. In vitro synergy between eravacycline and colistin was evaluated by using the chequerboard methodology. Synergistic activity was fo...

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem-...


Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals.

New antibiotics are urgently needed for the treatment of multidrug resistant infections. However, the production of novel antibiotics is diminishing. The enhancement of activity of available antibiotics through synergistic combination drug therapy may help in the management of patients with resistant infections.

Carbapenem-resistant Acinetobacter baumannii: Current status of the problem in four Bulgarian university hospitals (2014-2016).

A total of 226 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates was collected during 2014-2016 from in-patients aged 5-88 years in four Bulgarian university hospitals (H1-H4), to assess their antimicrobial susceptibility and to explore carbapenem resistance mechanisms, as well as the molecular epidemiology.

Emergence of Carbapenem Resistance in Bacteroides fragilis in China.

The antimicrobial resistance crisis makes it critically important for laboratories to closely monitor trends and mechanisms of emerging antimicrobial resistance in clinical isolates. Bacteroides fragilis is an anaerobic pathogen that causes several serious infections and is increasingly resistant to antimicrobials. However, data from China regarding antimicrobial resistance in B. fragilis are limited. In this work, we investigated the mechanism underlying carbapenem resistance in 44 B. fragilis isolates col...

Antimicrobial-resistant Gram-negative colonisation in infants from a NICU in Thailand.

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalised neonates in South and South-East Asia. We aimed to determine the dynamics of colonisation with antimicrobial-resistant Gram-negative bacteria amongst infants in a neonatal intensive care unit (NICU) in Thailand. From a total of 97 enrolled infants, 52% of neonates were colonised by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonised by a carbapenem-...

In vitro antimicrobial efficacy of laser exposed chlorpromazine against Gram-positive bacteria in planktonic and biofilm growth state.

Aqueous chlorpromazine solutions exposed to 266 nm generated as fourth harmonic of Nd:YAG pulsed laser along time intervals from 1 min to 240 min were investigated for their antimicrobial activity against planktonic and adherent Gram-positive bacterial strains. Qualitative and quantitative assays based on microbiological methods and flow cytometry assays were performed to establish the minimum inhibitory and minimum biofilm eradication concentrations and to reveal some of the possible mechanisms of an...

Peptide Conjugates Of Lactoferricin Analogues And Antimicrobials - Design, Chemical Synthesis, And Evaluation Of Antimicrobial Activity And Mammalian Cytotoxicity.

Eight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and one of the three antimicrobials - ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) - were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the "click chemistry" method. This novel approach is reported here for the first time. Unlike their components, CIP- and LVX-based conjugates ex...

Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37.

The incorporation of the innate immune system into humans is essential for survival and health due to the rapid replication of invading microbes and the delayed action of the adaptive immune system. Antimicrobial peptides are important components of human innate immunity. Over 100 such peptides have been identified in various human tissues. Human cathelicidin LL-37 is best studied, and there has been a growing interest in designing new peptides based on LL-37. This chapter describes the alternative processi...

A scorpion venom peptide derivative BmKn‒22 with potent antibiofilm activity against Pseudomonas aeruginosa.

Pseudomonas aeruginosa is a leading cause of nosocomial and serious life-threatening infections and infections caused by this bacterium continue to pose a major medical challenge worldwide. The ability of P. aeruginosa to produce multiple virulence factors and in particular to form biofilms makes this bacterium resistant to all known antibiotics. As a consequence, standard antibiotic therapy are increasingly become ineffective to clear such infections associated with biofilms. In search for novel effective ...

Trimethoprim-sulfamethoxazole vs. colistin or ampicillin-sulbactam for the treatment of carbapenem-resistant Acinetobacter baumannii: a retrospective matched cohort study.

We aimed to assess the effectiveness of trimethoprim-sulfamethoxazole (TMP/SMX) as monotherapy for the treatment of carbapenem-resistant A. baumannii (CRAB) infections.

Design, recombinant expression, and antibacterial activity of a novel hybrid magainin-thanatin antimicrobial peptide.

Antimicrobial peptides are small molecule polypeptides with biological activity, which can avoid the drug resistance. Magainin and thanatin are antimicrobial peptides with a broad spectrum of inhibitory microbes, and the core sequence of magainin is linked to a core sequence of thanatin. Here, the hybrid magainin-thanatin (MT) antimicrobial peptide was designed through bioinformatics analysis. The recombinant MT antimicrobial peptide was successfully expressed and purified in Escherichia coli BL21 (DE3). Th...

Dimerization of antimicrobial peptides: a promising strategy to enhance antimicrobial peptide activity.

Antimicrobial resistance is a global health problem with strong social and economic impacts. The development of new antimicrobial agents is considered an urgent challenge. In this regard, antimicrobial peptides (AMPs) appear to be novel candidates to overcome this problem. The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although the exact mechanism of action of AMPs remains controversial, most AMPs act through membrane disruption of the target cell. Several strategies...

Inactivation of the oprD porin gene by a novel insertion sequence ISPa195 associated with large deletion in a carbapenem resistant Pseudomonas aeruginosa isolate.

Alteration of the porin-coding oprD gene by insertion sequences (ISs) is one of the mechanisms conferring carbapenem resistance in Pseudomonas aeruginosa. In this study, we described a carbapenem resistant clinical isolate P. aeruginosa 36-989 harboring a novel IS (ISPa195) in oprD.

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K.

Antimicrobial peptides have been evaluated as possible alternatives to traditional antibiotics. The translational potential of the antimicrobial peptide DGL13K was tested with focus on peptide toxicity and in vivo activity in two animal models. DGL13K was effective against Pseudomonas aeruginosa, Staphylococcus aureus and methicillin-resistant S. aureus with minimal bactericidal concentrations similar to the minimal inhibitory concentration. The peptide showed low toxicity to human red blood cells and HEK c...

Prevalence and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii: A Comprehensive Systematic Review of Cross-Sectional Studies from Iran.

Carbapenem-resistant Acinetobacter baumannii (CRAB) is recognized to be among the most difficult antimicrobial-resistant gram-negative bacilli to control and treat. An understanding of the epidemiology of CRAB and the mechanisms of resistance to carbapenems is necessary to develop strategies to curtail their spread.

Long-read Nanopore Sequencing-based Draft Genome of a Carbapenem-resistant Pseudomonas aeruginosa.

Pseudomonas aeruginosa (P. aeruginosa) is a common Gram-negative bacterium that can cause a series of serious infections, such as lower respiratory tract infection, urinary-tract infections with catheterized patients. Here we reported the draft genome of carbapenem-resistant P. aeruginosa.

Carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA genes with an upstream ISAba1: The first report of a novel OXA subclass from Iran.

Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates.

Evaluation of the BD Phoenix automated system for determining antimicrobial susceptibility against carbapenem-resistant Enterobacteriaceae compared to broth microdilution.

Carbapenem-resistant Enterobacteriaceae (CRE) are increasingly widespread in the healthcare system, resulting in infections associated with mortality of up to 50%. Many laboratories utilize automated systems to identify CRE isolates and determine susceptibility. The aim of this study is to evaluate the categorical agreement between the automated system BD Phoenix and the gold standard - broth microdilution - in determining minimum inhibitory concentrations of CRE METHODOLOGY: We evaluated the activity of am...

Search for shorter portions of the proline-rich antimicrobial peptide fragment Bac5(1-25) that retain antimicrobial activity by blocking protein synthesis.

The spreading of antibiotic-resistant pathogens boosted the search for new antimicrobial drugs. Proline-rich antimicrobial peptides are promising lead compounds for the development of next-generation antibiotics, due to their very low cytotoxicity and their good antimicrobial activity targeting the bacterial ribosome. Bac5(1-25) is a N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5 whose mode of action has been recently described. In this work we tested a number of Bac5(1-25) fragme...

Carbapenem-resistant Enterobacteriaceae: An emerging bacterial threat.

The first reports of carbapenem resistance in Enterobacteriaceae isolates occurred in the early 1990s. Researchers published the first report of an isolate that produced Klebsiella pneumoniae carbapenemase in 2001. Since that time, carbapenemase-producing Enterobacteriaceae isolates have disseminated globally. Microbiology laboratories are integral to the control of carbapenem-resistant Enterobacteriaceae (CRE). Laboratories need to be able to identify CRE, identify possible therapeutic alternatives, and so...

Management of carbapenem resistant Enterobacteriaceae infections.

Carbapenem resistance is defined as in vitro nonsusceptibility to any carbapenem and/or documented production of a carbapenemase. This feature has rapidly spread worldwide among clinical isolates of Enterobacteriaceae, mostly Klebsiella spp, and is associated with diverse molecular mechanisms. Carbapenem resistance is often associated with resistance to all traditional beta-lactams and other classes of antibiotics, denoting a typical example of extensively drug-resistant phenotype.

Trends in antimicrobial resistance in Israel, 2014-2017.

We analyzed Israeli national data on antimicrobial susceptibility from bloodstream isolates collected between 2014 and 2017 and compared resistance proportions with those of Europe. The incidence of bloodstream infection (BSI) caused by most antibiotic-resistant organisms remained unchanged or decreased. An exception was increased incidence of BSI caused by third-generation cephalosporin-resistant . Overall, resistance proportions were similar to those observed in southern Europe, with the exception of a lo...

Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against .

is well adapted to hospital environments, and the persistence of its chronic infections is mainly due to its ability to form biofilms resistant to conventional antibiotics and host immune systems. Hence, the inhibitions of biofilm formation and virulence characteristics provide other means of addressing infections. In this study, the antibiofilm activities of twelve flavonoids were initially investigated. Three most active flavonoids, namely, fisetin, phloretin, and curcumin, dose-dependently inhibited biof...


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