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PubMed Journals Articles About "Tight Junction Modulation Chitosan Nanoparticles Comparison With Chitosan" RSS

11:43 EDT 22nd October 2017 | BioPortfolio

Tight Junction Modulation Chitosan Nanoparticles Comparison With Chitosan PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Tight Junction Modulation Chitosan Nanoparticles Comparison With Chitosan articles that have been published worldwide.

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Showing "Tight junction modulation chitosan nanoparticles comparison with chitosan" PubMed Articles 1–25 of 8,000+

Antimicrobial activity of chitosan and a chitosan oligomer against bacterial pathogens of warmwater fish.

The antibacterial activities of chitosan (CS) and its derivative chitosan oligosaccharide lactate (COL) were evaluated against Aeromonas hydrophila, Edwardsiella ictaluri and Flavobacterium columnare, three highly pathogenic bacteria of warmwater finfish.


Vitamin D-fortified chitosan films from mushroom waste.

Brown mushroom (Agaricus bisporus) stalk bases from mushroom waste were treated with UV-B light to rapidly increase vitamin D2 content. Chitin was also recovered from this waste and converted into chitosan by N-deacetylation. FTIR spectra showed that the mushroom chitosan were similar to chitosan from animal sources. Chitosan films were prepared using high molecular weight (HW), low molecular weight (LW) and fungal chitosan. UV-B treated mushroom particles were also incorporated into fungal chitosan films. ...

Chitosan-lipid nanoparticles (CS-LNPs): Application to siRNA delivery.

To benefit from the biocompatibility of lipid nanoparticles associated with the transfection ability of chitosan, small chitosan lipid nanoparticles (CS-LNPs) dedicated to SiRNA delivery were formulated by an easy-to-implement one-step process. Formulations of CS-LNPs (lipid core stabilized by a shell comprising phospholipids/cationic lipids and hydrophobically modified chitosan) were optimized for their physico-chemical properties (size, zeta potential, colloidal stability) according to their shell composi...


Comparison of chitosan and chitosan nanoparticles on the performance and charge recombination of water-based gel electrolyte in dye sensitized solar cells.

In commercialization of liquid dye-sensitized solar cells (DSSCs), whose leakage, evaporation and toxicity of organic solvents are limiting factors, replacement of organic solvents with water-based gel electrolyte is recommended. This work reports on utilizing and comparison of chitosan and chitosan nanoparticle as different gelling agents in preparation of water-based gel electrolyte in fabrication of dye sensitized solar cells. All photovoltaic parameters such as open circuit voltage (Voc), fill factor (F...

Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats.

The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight ...

Colorimetric detection of biothiols based on aggregation of chitosan-stabilized silver nanoparticles.

We have described a simple and reliable colorimetric method for the sensing of biothiols such as cysteine, homocysteine, and glutathione in biological samples. The selective binding of chitosan capped silver nanoparticles to biothiols induced aggregation of the chitosan-Ag NPs. But the other amino acids that do not have thiol group cannot aggregate the chitosan-Ag NPs. Aggregation of chitosan-Ag NPs has been confirmed with UV-vis absorption spectra, zeta potential and transmission electron microscopy images...

Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy.

Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and ch...

Preparation and characterization of ZnO nanoparticles coated by chitosan-linoleic acid; fungal growth and biofilm assay.

This study has been carried out on reviewing the use of new synthetic component of zinc oxide nanoparticles (ZnO NPs) coated by Chitosan-linoleic acid (CS-LA) and to assess Minimum inhibitory concentration (MIC) of nanoparticles on clinical samples and biofilm formation in vitro.

Chitosan as a bioactive polymer: processing, properties and applications.

Chitin is one of the most abundant natural polysaccharides in the world and it is mainly used for the production of chitosan by a deacetylation process. Chitosan is a bioactive polymer with a wide variety of applications due to its functional properties such as antibacterial activity, non-toxicity, ease of modification, and biodegradability. This review summarizes the most common chitosan processing methods and highlights some applications of chitosan in various industrial and biomedical fields. Finally, en...

Cisplatin-Mediated Formation of Polyampholytic Chitosan Nanoparticles with Attenuated Viscosity and pH-Sensitive Drug Release.

Chitosan is a biocompatible natural polysaccharide, which has been employed as a polymeric scaffold for versatile, systemic delivery platforms and for locally injectable gels with temperature-sensitive viscosity modulation. Despite the extensive investigation on the chemical modification strategies, however, most of the chitosan-based delivery platforms have been focused on the encapsulation of hydrophobic drugs, which can be simply adsorbed on the chitosan scaffolds by hydrophobic interaction via the postp...

Mucoadhesive properties of low molecular weight chitosan- or glycol chitosan- and corresponding thiomer-coated poly(isobutylcyanoacrylate) core-shell nanoparticles.

The aim of the present work was to evaluate the mucoadhesive properties of poly(isobutyl cyanoacrylate) (PIBCA) nanoparticles (NPs) coated with Low Molecular Weight (LMW) chitosan (CS)- and glycol chitosan (GCS)-based thiomers as well as with the corresponding LMW unmodified polysaccharides. For this purpose, all the CS- and GCS-based thiomers were prepared under simple and mild conditions starting from the LMW unmodified polymers CS and GCS. The resulting NPs were of spherical shape with diameters ranging ...

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics.

Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem ce...

Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for positively charged drugs.

Recently, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation was shown to be beneficial for the iontophoretic transdermal delivery of therapeutic agents. Also, this preparation method can contain a hydrophilic drug. However, since PLGA nanoparticles were negatively charged, it was difficult to apply iontophoresis for positively charged hydrophilic drugs. In this study, we prepared positively charged PLGA nanoparticle...

Comparison in Docetaxel-loaded Nanoparticles based on three different Carboxymethyl Chitosans.

In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potent...

Protein adsorption of dialdehyde cellulose-crosslinked chitosan with high amino group contents.

Crosslinked chitosan was prepared by Schiff base formation between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of chitosan and a subsequent reduction. DAC was obtained through periodate oxidation of cellulose and solubilization in hot water at 100°C for 1h. Three grades of DAC-crosslinked chitosan were prepared by adding various amounts DAC. The degrees of crosslinking as determined by amino group content were 3.8, 8.3, and 12.1%, respectively. DAC-crosslinked chitosan showed hig...

tRNA conjugation with folic acid-chitosan conjugates.

The conjugation of tRNA with folic acid-chitosan conjugates was studied, using multiple spectroscopic methods and transmission electron microscopy (TEM). Thermodynamic analysis ΔH -14 to -10 (KJ. Mol(-1)) and ΔS 14 to -1 (J. Mol(-1), K(-1)) showed tRNA-folic acid-chitosan bindings occur via H-bonding, hydrophobic and van der Waals contacts. The loading efficacy and the stability of tRNA conjugates were enhanced as folic acid-chitosan size increased. TEM analysis showed major tRNA morphological changes, up...

Characterization of bioactive chitosan and sulfated chitosan from Doryteuthis singhalensis (Ortmann, 1891).

Chitosan was extracted from the pen of squid Doryteuthis singhalensis and was characterized using FT-IR, NMR, CHN, SEM and DSC analysis. Purified chitosan was sulfated with chlorosulfonic acid in N,N-dimethylformamid and the added sulfate group was confirmed with FT-IR analysis. The molecular weight and degree of deacetylation (DDA) of chitosan was found 226.6kDa and 83.76% respectively. Chitosan exhibited potent antioxidant activity evidenced by reducing power, chelating ability on ferrous ions and scaveng...

Chitosan: A Potential Biopolymer for Wound Management.

It has been seen that slow healing and non-healing wounds conditions are treatable but still challenging to humans. Wound dressing usually seeks for biocompatible and biodegradable recipe. Natural polysaccharides like chitosan have been examined for its antimicrobial and healing properties on the basis of its variation in molecular weight and degree of deacetylation. Chitosan adopts some vital characteristics for treatment of various kinds of wounds which include its bonding nature, antifungal, bactericidal...

Biocompatibility and fabrication of RGO/chitosan film for cartilage tissue recovery.

Graphene oxide (GO) has been successfully deoxygenated via an environmental friendly approach using chitosan. The prepared RGO was characterized using several microscopic and spectroscopic techniques. Also, the synthesized RGO is used to develop a highly compatible film with chitosan. Further, the in-vitro cytotoxicity results showed the biocompatible nature of prepared RGO/chitosan composite towards the human articular chondrocytes indicating their use in future cartilage tissue engineering applications.

Physicochemical properties and characterization of chitosan synthesized from fish scales, crab and shrimp shells.

Chitosan is derived from different starting materials such as fish scales, shrimp and crab shells by the process of deacetylation of chitin, which is carried out using 40% KOH at 90°C for 6hours. Prepared chitosan was characterized by Fourier transforms infrared spectroscopy, X-ray powder diffraction, Scanning electron microscope and Thermogravimetric analysis. Futher the physicochemical properties of chitosan like Fat binding capacity (FBC), water binding capacity (WBC), solubility, average molecular weig...

Bio-based chitosan nanocomposite films containing gold nanoparticles. Obtaining, characterization and catalytic activity assessment.

A "green" two-step methodology to prepare bio-based gold-chitosan nanocomposite films using chitosan and AuCl4- as a stabilizer and precursor, respectively, is reported. The bio-based nanocomposites were prepared in situ by a wet chemical reduction method. Effects of hydrazine and L-ascorbic acid as different strength reducing agents on the characteristics of gold nanoparticles were observed. In addition, the performance of these nanocomposite films as catalytic materials was assessed. The relevance of this...

Removal of Arsenic (V) from Aqueous Solutions Using Chitosan-Red Scoria and Chitosan-Pumice Blends.

In different regions across the globe, elevated arsenic contents in the groundwater constitute a major health problem. In this work, a biopolymer chitosan has been blended with volcanic rocks (red scoria and pumice) for arsenic (V) removal. The effect of three blending ratios of chitosan and volcanic rocks (1:2, 1:5 and 1:10) on arsenic removal has been studied. The optimal blending ratio was 1:5 (chitosan: volcanic rocks) with maximum adsorption capacity of 0.72 mg/g and 0.71 mg/g for chitosan: red scoria ...

Preparation and Characterization of Chitosan Obtained from Shells of Shrimp (Litopenaeus vannamei Boone).

The main source of commercial chitosan is the extensive deacetylation of its parent polymer chitin. It is present in green algae, the cell walls or fungi and in the exoskeleton of crustaceans. A novel procedure for preparing chitosan from shrimp shells was developed. The procedure involves two 10-minutes bleaching steps with ethanol after the usual demineralization and deproteinization processes. Before deacetylation, chitin was immersed in 12.5 M NaOH, cooled down and kept frozen for 24 h. The obtained chi...

Efficacy of Carboxymethyl Chitosan against Candida tropicalis and Staphylococcus epidermidis Polymicrobial Biofilms.

Polymicrobial biofilms with fungi and bacteria are the leading cause for the failure of medical devices and related infections. In this study, antibiofilm activities of carboxymethyl chitosan (CM-chitosan) on polymicrobial biofilms of Staphylococcus epidermidis and Candida tropicalis in vitro were evaluated. CM-chitosan was effective as a sole agent, inhibiting both monomicrobial and polymicrobial biofilms in microplates and also on the silicone surface in short- and long-term periods. Biofilm architecture ...

Fabrication of biosensor based on Chitosan-ZnO/Polypyrrole nanocomposite modified carbon paste electrode for electroanalytical application.

A sensitive conductive nanocomposite sensor consisting of chitosan, zinc oxide nanoparticles, and polypyrrole was developed. The sensor was prepared by oxidative polymerization of pyrrole using (NH4)2S2O8 as the oxidant followed by mixing a Chitosan-Zinc oxide composite with a different content of Chitosan. The morphology and surface area of the nanocomposites were changed by changing the percentage of chitosan. The newly developed nanocomposites also showed a significant improvement in electrical conductiv...


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