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PubMed Journals Articles About "Tolterodine Oxybutynin Memory" RSS

08:51 EST 20th February 2018 | BioPortfolio

Tolterodine Oxybutynin Memory PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Tolterodine Oxybutynin Memory articles that have been published worldwide.

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Showing "Tolterodine Oxybutynin Memory" PubMed Articles 1–25 of 2,100+

Simultaneous determination of tolterodine and its two metabolites, 5-hydroxymethyltolterodine and N-dealkyltolterodine in human plasma using LC-MS/MS and its application to a pharmacokinetic study.

Tolterodine is a nonselective muscarinic antagonist that is indicated for the overactive urinary bladder and other urinary difficulties. We developed and validated a simple, rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma. After liquid-liquid extraction with methyl t-butyl ether, chromatogr...


Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults.

There are no reliably effective, well-tolerated topical agents for the treatment of hyperhidrosis. We sought to evaluate the efficacy and tolerability of oxybutynin 3% gel in adolescents and young adults with primary focal hyperhidrosis.

'It is nothing more than a senior moment': the moderating role of subjective age in the effect of change in memory on self-rated memory.

The association between memory performance and self-rated memory is yet to be understood. More specifically, little is known about the factors that lie at the base of self-evaluations of memory in relation to actual changes in memory. In this study, we suggest that subjective age modifies the effect of objective change in memory on self-rated memory.


The effect of tablet containing Boswellia serrata and Melisa officinalis extract on older adults' memory: A randomized controlled trial.

Memory deficits and age-related memory loss are currently two significant concerns in older adults. In Iranian herbal medicine, there are some prescriptions for memory improvement.

miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development thr...

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation.

The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch effectiveness, ...

Attentional influences on memory formation: A tale of a not-so-simple story.

Is there a learning mechanism triggered by mere expectation violation? Is there some form of memory enhancement inherent to an event mismatching our predictions? Across seven experiments, we explore this issue by means of a validity paradigm. Although our manipulation clearly succeeded in generating an expectation and breaking it, the memory consequences of that expectation mismatch are not so obvious. We report here evidence of a null effect of expectation on memory formation. Our results (1) show that enh...

Neuropeptide Y prolongs non-social memory and differentially affects acquisition, consolidation, and retrieval of non-social and social memory in male mice.

Neuropeptide Y (NPY) and its receptors (especially Y1, Y2, and Y5) are highly expressed in brain regions involved in learning and memory processes. Accordingly, NPY was shown to modulate cognitive functions in rodents. Here, we investigated possible memory-enhancing effects of NPY and determined the role of the NPY system in the acquisition, consolidation, and retrieval of non-social and social memory in mice, using the object and social discrimination tests, respectively. Intracerebroventricular (icv) infu...

Memory Retrieval: Taking the Route via Subiculum.

An episodic memory goes through three different stages: acquisition, consolidation and recall. A new study suggests that distinct microcircuits in the hippocampus underlie the process of memory acquisition and recall.

Investigating patterns of memory impairment in ischemic stroke in an iranian population.

Up until the date of this research, studies have examined poststroke cognitive impairments in attention, memory, and executive functions. In this study, we investigated the occurrence of memory problems in various patterns of memory in ischemic stroke patients in an attempt to determine specific memory profiles of the patients. The goal was to determine the severity and patterns of memory impairments in ischemic stroke patients and to identify specific profiles of memory impairments in stroke patients, in o...

Not explicit but implicit memory is influenced by individual perception style.

Not only explicit but also implicit memory has considerable influence on our daily life. However, it is still unclear whether explicit and implicit memories are sensitive to individual differences. Here, we investigated how individual perception style (global or local) correlates with implicit and explicit memory. As a result, we found that not explicit but implicit memory was affected by the perception style: local perception style people more greatly used implicit memory than global perception style peopl...

Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication.

Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT2 receptor nulls memory impairment during MDMA intoxication. Interestingly, studies have demonstrated that the eCB and the 5-HT system interact. It was hypothesized that MDMA would cause an increase in eCB concentrations together with a decrease in memory performance, and that combining MDMA with a 5-HT2 receptor blocker ketanserin would lead...

Accelerated long-term forgetting and autobiographical memory disorders in temporal lobe epilepsy: One entity or two?

Temporal lobe epilepsy (TLE) is a type of epilepsy that often has a negative impact on patients' memory. Despite the importance of patients' complaints in this regard, the difficulties described by these patients are often not easy to demonstrate through a standard neuropsychological assessment. Accelerated long-term forgetting and autobiographical memory disorders are the two main memory impairments reported in the literature in patients with TLE. However, the methods used by different authors to evaluate ...

Memory rehabilitation for the working memory of patients with multiple sclerosis (MS).

The main cognitive impairments in multiple sclerosis (MS) affect the working memory, processing speed, and performances that are in close interaction with one another. Cognitive problems in MS are influenced to a lesser degree by disease recovery medications or treatments,but cognitive rehabilitation is considered one of the promising methods for cure. There is evidence regarding the effectiveness of cognitive rehabilitation for MS patients in various stages of the disease. Since the impairment in working m...

Electroconvulsive therapy regulates emotional memory bias of depressed patients.

Emotional memory bias is considered to be an important base of the etiology of depression and can be reversed by antidepressants via enhancing the memory for positive stimuli. Another antidepressant treatment, electroconvulsive therapy (ECT), has rapid antidepressant effect and frequently causes short-term memory impairment. However, it is unclear about the short-term effect of ECT on memory bias. In this study, the incidental memory task with emotional pictures were applied to evaluate the emotional memory...

Randomized Controlled Trial Evaluating the Temporal Effects of High-Intensity Exercise on Learning, Short-Term and Long-Term Memory, and Prospective Memory.

To examine the temporal effects of high-intensity exercise on learning, short-term and long-term retrospective memory and prospective memory. Among a sample of 88 young adult participants, 22 were randomized into one of four different groups: exercise before learning, control group, exercise during learning and exercise after learning. The retrospective assessments (learning, short-term and long-term memory) were assessed using the Rey Auditory Verbal Learning Test. Short-term memory included a 20-min delay...

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage.

The abundant synaptic protein CaMKII is necessary for long-term potentiation (LTP) and memory. However, whether CaMKII is required only during initial processes or whether it also mediates memory storage remains unclear. The most direct test of a storage role is the erasure test. In this test, a putative memory molecule is inhibited after learning. The key prediction is that this should produce persistent memory erasure even after the inhibitory agent is removed. We conducted this test using transient viral...

Intraoperative Identification and Preservation of Verbal Memory in Diffuse Gliomas: A Matched-Pair Cohort Study.

Recent glioma surgery series with intraoperative electrical stimulation (IES) language mapping have demonstrated high rates of postoperative memory impairment, raising a question regarding the efficacy of this approach to preserve memory.

Female verbal memory advantage in temporal, but not frontal lobe epilepsy.

Women show better performance than men on a range of episodic memory tasks. Evidence regarding a neuroanatomical localization of this effect remains ambiguous. It has been suggested that anterior temporal lobe structures are responsible for sex differences in verbal memory, yet temporal lobe epilepsy (TLE) and TLE surgery do not affect women's verbal memory advantage. Instead, frontal lobe regions may be relevant for female verbal memory superiority, i.e. by enabling more efficient encoding and retrieval st...

Fluoxetine Inhibits Natural Decay of Long-Term Memory via Akt/GSK-3β Signaling.

Understanding the mechanisms underlying the natural decay of long-term memory can help us find means of extending the duration of long-term memory. However, the neurobiological processes involved in the decay of long-term memory are poorly understood. In the present study, we examined the effect of acute and chronic treatment of fluoxetine on natural decay of long-term memory and the possible mechanism. Late administration of fluoxetine prolonged the persistence of long-term memory in mice, as demonstrated ...

Seven myths of memory.

In this paper we highlight seven myths about memory, which centre around the fact that memories, as we experience them, are not only about the past, they are also prospective. Although episodic memory provides the template for future scenarios, it can be reassessed each time it is recalled, and in part is dependent on the sequence in which events unfold. We explore seven myths about memory, and the relationship between memory and experience. We refer to 'The Moustachio Quartet', a series of novels, which hi...

Destination memory: the relationship between memory and social cognition.

Destination memory refers to the ability to remember to whom one has sent information (e.g., "did I tell my colleague X or Y about the conference?", "did I send that email to my colleague X or Y?"). This review describes empirical studies demonstrating how normal aging and neurological disorders compromise destination memory. Centrally, we propose a comprehensive framework, destination memory framework (DMF), in which destination memory contributes to the uniqueness of a communications episode by creating a...

When is working memory important for arithmetic? The impact of strategy and age.

Our ability to perform arithmetic relies heavily on working memory, the manipulation and maintenance of information in mind. Previous research has found that in adults, procedural strategies, particularly counting, rely on working memory to a greater extent than retrieval strategies. During childhood there are changes in the types of strategies employed, as well as an increase in the accuracy and efficiency of strategy execution. As such it seems likely that the role of working memory in arithmetic may also...

Evidence of Objective Memory Impairments in Deployed Gulf War Veterans With Subjective Memory Complaints.

Despite the fact that many veterans returned from the 1991 Gulf War (GW) with complaints of memory difficulties, most neuropsychological studies to date have found little evidence of a correspondence between subjective and objective measures of cognitive function in GW veterans. However, if GW veterans complain about memory problems, it is likely that they experience memory problems in their daily lives. In this respect, it is notable that the past studies that have investigated the relationship between sub...

Steric twist effect-induced different ternary memory characteristics in non-conjugated copolymers with pendant naphthalene and 1,8-naphthalimide moieties.

In this paper, novel random copolymer PMNN and PMNB were designed and synthesized, and the memory devices Al/PMNN or PMNB/ITO both exhibit the ternary memory performance. The switching voltages of OFF-ON1 and ON1-ON2transitions for both memory devices are around -2.0 V and -3.5 V, respectively, and the ON1/OFF, ON2/ON1 current ratio are both up to 103. The observed tristable electrical conductivity switching could be attributed to field-induced conformational ordering of naphthalene ring in the side chain, ...


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