PubMed Journals Articles About "Tolterodine Oxybutynin Memory" RSS

05:52 EDT 16th October 2018 | BioPortfolio

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Showing "Tolterodine Oxybutynin Memory" PubMed Articles 1–25 of 2,300+

Combination of topical agents and oxybutynin as a therapeutic modality for patients with both osmidrosis and hyperhidrosis.

The association of osmidrosis and hyperhidrosis often causes emotional and social problems that may impair the patients' quality of life. The purpose of our study was to analyze the therapeutic results of oxybutynin and topical agents in 89 patients with both osmidrosis and hyperhidrosis.

Intradetrusor onabotulinumtoxinA injections are significantly more efficacious than oral oxybutynin for treatment of neurogenic detrusor overactivity: results of a randomized, controlled, 24-week trial.

To prospectively compare the results of intradetrusor onabotulinumtoxinA injections and oral oxybutynin for urinary continence, urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity due to spinal cord injury.

Oxybutynin for Hot Flashes Due to Androgen Deprivation in Men.

Atypical aquagenic keratoderma treated with oxybutynin chloride.

Opinion: Virtual memory CD8 T cells and lymphopenia-induced memory CD8 T cells represent a single subset: homeostatic memory T cells.

It is well established that lymphopenia induces the formation of the memory-phenotype T cells without the exposure to foreign antigens. More recently, the memory-phenotype antigen-inexperienced memory T cells were described in lymphoreplete mice and called virtual memory T cells. In this review, we compare multiple aspects of the biology of lymphopenia-induced memory T cells and virtual memory T cells, including cytokine requirements, the role of T-cell receptor specificity in the differentiation process, g...

Improving everyday memory performance after acquired brain injury: An RCT on recollection and working memory training.

To show the effectiveness of a combined recognition and working memory training on everyday memory performance in patients suffering from organic memory disorders.

Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.

QT interval prolongation typically assessed with dedicated clinical trials called thorough QT/QTc (TQT) studies is used as surrogate to identify the proarrhythmic risk of drugs albeit with criticism in terms of cost-effectiveness in establishing the actual risk of torsade de pointes (TdP). Quantitative systems toxicology and safety (QSTS) models have potential to quantitatively translate the in vitro cardiac safety data to clinical level including simulation of TQT trials. Virtual TQT simulations have been ...

Novelty enhances memory persistence and remediates propranolol-induced deficit via reconsolidation.

Memory reactivation has been shown to open a time window for memory modulation. The majority of the methodological or pharmacological approaches target disruption of reconsolidation to weaken aversive memories. However, methods to improve appetitive memory persistence through reconsolidation or to reverse drug-induced reconsolidation impairment are limited. To improve memory persistence, previous studies show that a novel event, introduced around the time of memory encoding, enables the persistence of an ot...

Strength in diversity: Phenotypic, functional, and molecular heterogeneity within the memory B cell repertoire.

The vast majority of vaccines exploit antibody memory to induce lasting immunity. Memory B cells are generated during the initial response to infection, but persist long after the infection has cleared. Immune memory success relies on its adaptability: in response to different pathogens, variants of a single pathogen, and in balancing persistence with reactivation and plasma cell differentiation. This is likely achieved by producing a B cell memory population that is highly diverse, and recent work has high...

Development and Psychometric Validation of a Question naire Assessing the Impact of Memory Changes in Older Adults.

Many healthy older adults experience age-related memory changes that can impact their day-to-day functioning. Qualitative interviews have been useful in gaining insight into the experience of older adults who are facing memory difficulties. To enhance this insight, there is a need for a reliable and valid measure that quantifies the impact of normal memory changes on daily living. The primary objective of this study was to develop and validate a new instrument, the Memory Impact Questionnaire (MIQ).

Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents.

Rapid, neurosteroid-like effects of estrogens on memory consolidation during recognition memory tasks in both male and female rodents are described. We discuss how these mnemonic changes are related to rapid estrogenic effects on dendritic spine density, the distribution of spine types and the expression of PSD95 and GluA2 within spines in the hippocampus and medial prefrontal cortex, two areas critical for learning and memory. Overall, these data lead to the conclusion that estrogens are capable of exertin...

Patients' accounts of memory lapses in interactions between neurologists and patients with functional memory disorders.

One of the most commonly made diagnoses in secondary care memory services is functional memory disorder (FMD). FMD is non-progressive and characterised by persistent worries about memory failures without objective evidence of cognitive impairment. This study explores how patients with FMD present their memory concerns. Utilizing video recordings of consultations between patients and neurologists in a memory clinic, we show that FMD patients account for their memory deficits as significant disruptions to the...

Localizing memory functions in brain tumor patients: anatomical hotspots over 260 patients.

Memory complaints are common in brain tumor patients, but is difficult to map memory functions during awake surgery, to preserve them. Thus we analyzed one of the largest data set on clinical, surgical and anatomical correlates of memory in brain tumor patients to date, providing anatomical hotspots for short and long term memory functions.

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells.

Virtual memory T cells are foreign antigen-inexperienced T cells that have acquired memory-like phenotype and constitute 10-20% of all peripheral CD8 T cells in mice. Their origin, biological roles, and relationship to naïve and foreign antigen-experienced memory T cells are incompletely understood. By analyzing T-cell receptor repertoires and using retrogenic monoclonal T-cell populations, we demonstrate that the virtual memory T-cell formation is a so far unappreciated cell fate decision checkpoint. We d...

Coaching positively influences the effects of working memory training on visual working memory as well as mathematical ability.

The goal of the present study was to test whether the amount of coaching influenced the results of working memory training on both visual and verbal working memory. Additionally, the effects of the working memory training on the amount of progress after specific training in mathematics were evaluated. In this study, 23 children between 9 and 12 years of age with both attentional and mathematical difficulties participated in a working memory training program with a high amount of coaching, while another 25 c...

mTORC1 controls long-term memory retrieval.

Understanding how stored information emerges is a main question in the neurobiology of memory that is now increasingly gaining attention. However, molecular events underlying this memory stage, including involvement of protein synthesis, are not well defined. Mammalian target of rapamycin complex 1 (mTORC1), a central regulator of protein synthesis, has been implicated in synaptic plasticity and is required for memory formation. Using inhibitory avoidance (IA), we evaluated the role of mTORC1 in memory retr...

Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis.

Two functional networks are proposed as neuronal support for the complex processes of memory: the anterior temporal and the medial posterior systems. We examined the atrophy of hippocampus (HC) and of those areas constituting the two functional memory systems in multiple sclerosis (MS) patients with low disability.

Experimental Effects of Acute Exercise on Episodic Memory Function: Considerations for the Timing of Exercise.

Our previous work employing a between-subject randomized controlled trial design suggests that exercising prior to memory encoding is more advantageous in enhancing retrospective episodic memory function when compared to exercise occurring during or after memory encoding. The present experiment evaluates this potential temporal effect of acute exercise on memory function while employing a within-subject, counterbalanced design. In a counterbalanced order (via Latin squares), 24 participants completed four v...

Calcium/calmodulin-dependent kinase II and memory destabilization: a new role in memorymaintenance.

In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases retrieval-induced memory destabilization. We then proceed to propose two potential molecular pathways to explain the association between CaMKII activation and increased memory destabilization. ...

Preferential consolidation of emotionally salient information during a nap is preserved in middle age.

Sleep preferentially preserves aspects of memory that are most salient and valuable to remember at the expense of memory for less relevant details. Daytime naps and nocturnal sleep enhance this emotional memory trade-off effect, with memory for emotional components correlated with slow-wave sleep during the day and rapid eye movement sleep overnight. However, these studies have primarily sampled from young adult populations. Sleep and memory are altered by middle age, and the aim of the present study was to...

Failure of self-consistency in the discrete resource model of visual working memory.

The discrete resource model of working memory proposes that each individual has a fixed upper limit on the number of items they can store at one time,due to division of memory into a few independent "slots". According to this model, responses on short-term memory tasks consist of a mixture of noisy recall (when the tested item is in memory) and random guessing (when the item is not in memory). This provides two opportunities to estimate capacity for each observer: first, based on their frequency of random g...

The role of sleep in emotional memory processing in middle age.

Sleep benefits memory in young adults, and this effect may be particularly strong for representations associated with negative emotion. Many aspects of sleep important for memory consolidation change with aging, particularly by middle age, suggesting that sleep-related consolidation may be reduced. However, the influence of sleep on memory has rarely been investigated in a middle-aged population. In the current study, young and middle-aged adults viewed negative and neutral pictures and underwent a recognit...

Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory.

The CA3 subregion of the hippocampus is important for rapid encoding, storage and retrieval of associative memories. Lesions and pharmacological inhibitions of hippocampal CA3 suggest that it is essential for different memories. However, how CA3 functions in spatial and episodic memory in different time scales (i.e. short-term versus long term) without permanent lesions has not been systematically investigated yet. Taking advantage of the chemogenetic access to opsins, this study used luminopsins, fusion pr...

Retrospective attention in short-term memory has a lasting effect on long-term memory across age.

Declines in both short- and long-term memory are typical of healthy aging. Recent findings suggest that retrodictive attentional cues ("retro-cues") that indicate the location of to-be-probed items in short-term memory (STM) have a lasting impact on long-term memory (LTM) performance in young adults. Whether older adults can also use retro-cues to facilitate both STM and LTM is unknown.

Theta band network supporting human episodic memory is not activated in the seizure onset zone.

Episodic memory, everyday memory for events, is frequently impaired in patients with epilepsy. We tested patients undergoing intracranial electroencephalography (intracranial EEG) monitoring for the treatment of medically-refractory epilepsy on a well-characterized paradigm that requires episodic memory. We report that an anatomically diffuse network characterized by theta-band (4-7 Hz) coherence is activated at the time of target selection in a task that requires episodic memory. This distinct network of...

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