Advertisement

Topics

PubMed Journals Articles About "Towers Watson" RSS

07:06 EDT 20th October 2018 | BioPortfolio

Towers Watson PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Towers Watson articles that have been published worldwide.

More Information about "Towers Watson" on BioPortfolio

We have published hundreds of Towers Watson news stories on BioPortfolio along with dozens of Towers Watson Clinical Trials and PubMed Articles about Towers Watson for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Towers Watson Companies in our database. You can also find out about relevant Towers Watson Drugs and Medications on this site too.

Showing "Towers Watson" PubMed Articles 1–25 of 46

The 5-oxyacetic acid modification destabilizes double helical stem structures and favors anionic Watson-Crick like cmo5U-G base pairs.

: Watson-Crick like G-U mismatches with tautomeric Genol or Uenol bases can evade fidelity checkpoints and thereby contribute to translational errors. The 5-oxyacetic acid uridine (cmo5U) modification is a base modification at the wobble position on tRNAs and is presumed to expand the decoding capability of tRNA at this position by forming Watson-Crick like cmo5Uenol-G mismatches. A detailed investigation on the influence of the cmo5U modification on structural and dynamic features of RNA was carried out us...


Outside the Ivory Towers.

Contributions of Jean Watson's theory to holistic critical thinking of nurses.

to reflect on the contributions of Jean Watson's theory to the nurses' holistic critical thinking.


Young children fail to generate an additive ratchet effect in an open-ended construction task.

The ratchet effect-the gradual accumulation of changes within a cultural trait beyond a level that individuals can achieve on their own-arguably rests on two key cognitive abilities: high-fidelity social learning and innovation. Researchers have started to simulate the ratchet effect in the laboratory to identify its underlying social learning mechanisms, but studies on the developmental origins of the ratchet effect remain sparse. We used the transmission chain method and a tower construction task that had...

Does the Watson-Jones or Modified Smith-Petersen Approach Provide Superior Exposure for Femoral Neck Fracture Fixation?

A well-reduced femoral neck fracture is more likely to heal than a poorly reduced one, and increasing the quality of the surgical exposure makes it easier to achieve anatomic fracture reduction. Two open approaches are in common use for femoral neck fractures, the modified Smith-Petersen and Watson-Jones; however, to our knowledge, the quality of exposure of the femoral neck exposure provided by each approach has not been investigated.

James Watson at 90.

Classifications in Brief: Watson and Ballet Classification of Scapholunate Advanced Collapse Wrist Arthritis.

Gene expression assay and Watson for Oncology for optimization of treatment in ER-positive, HER2-negative breast cancer.

Personalized treatment for cancer patients is a hot topic of debate, particularly the decision to initiate chemotherapy in patients with Estrogen receptor (ER)-positive, HER2-negative tumors in the early stages of breast cancer (BC). Owing to significant advancements in information technology (IT) and genomics, clinicians are increasingly attaining therapeutic goals rapidly and safely by effectively differentiating patient subsets that require chemotherapy. IBM Watson for Oncology (WFO) is a cognitive compu...

Novel pathway for mutagenic tautomerization of classical А∙Т DNA base pairs via sequential proton transfer through quasi-orthogonal transition states: A QM/QTAIM investigation.

In this paper we have theoretically predicted a novel pathway for the mutagenic tautomerization of the classical A∙T DNA base pairs in the free state, the Watson-Crick A·Т(WC), reverse Watson-Crick A·Т(rWC), Hoogsteen A·Т(H) and reverse Hoogsteen A·Т(rH) pairs, via sequential proton transfer accompanied by a significant change in the mutual orientation of the bases. Quantum-mechanical (QM) calculations were performed at the MP2/aug-cc-pVDZ//B3LYP/6-311++G(d,p) level in vacuum phase, along with Bad...

Enrichment of free-living amoebae in biofilms developed at upper water levels in drinking water storage towers: An inter- and intra-seasonal study.

Free-living amoebae (FLA) are ubiquitous organisms present in various natural and artificial environments, such as drinking water storage towers (DWST). Some FLA, such as Acanthamoeba sp., Naegleria fowleri, and Balamuthia mandrillaris, can cause severe infections at ocular or cerebral level in addition to being potential reservoirs of other pathogens. In this work, the abundance and diversity of FLA was evaluated in two sampling campaigns: one performed over five seasons in three DWST at three different le...

Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer.

Watson et al. use microenvironment microarrays to assess how extrinsic signals within the tumor microenvironment influence HER2breast cancer resistance to the HER2-targeted tyrosine kinase inhibitor lapatinib.

Molecular dynamics analysis of stabilities of the telomeric Watson-Crick duplex and the associated i-motif as a function of pH and temperature.

This work deals with a molecular dynamics analysis of the protonated and deprotonated states of the natural sequence d[(CCCTAA)CCCT] of the telomeric DNA forming the intercalated i-motif or paired with the sequence d[(CCCTAA)CCCT] and forming the Watson-Crick (WC) duplex. By utilizing the amber force field for nucleic acids we built the i-motif and the WC duplex either with native cytosines or using their protonated forms. We studied, by applying molecular dynamics simulations, the role of hydrogen bonds be...

Contribution of transpersonal care to cardiac patients in the postoperative period of heart surgery.

To know the contribution of Watson's theory to nursing care for cardiac patients in the postoperative period of cardiac surgery.

65 YEARS OF THE DOUBLE HELIX: Could Watson and Crick have envisioned the true impact of their discovery?

Landmark scientific findings are applauded. However, at the time of discovery, the future impact that these types of new knowledge might have on patients is not foreseen. This article discusses how unraveling the structure of DNA has advanced medical treatment, particularly for patients with rare diseases. In addition, each new scientific discovery brings with it the emotion of for improved diagnosis and treatment, as well as enhanced outcomes and increased longevity for patients facing a life-long disease...

What is real success in nursing research?

Who and what can define what success is in research? With the United Kingdom's seven-yearly Research Excellence Framework and recent anniversaries such as the 40 of the Journal of Advanced Nursing providing an opportunity to look back and assess progress made and successes achieved. But how much do we do this as individual researchers?. Research success in nursing occurs mostly in a small disciplinary goldfish bowl. While the profession has progressed in terms of the number of journals, professors and volum...

Double Resummation for Higgs Production.

We present the first double-resummed prediction of the inclusive cross section for the main Higgs production channel in proton-proton collisions, namely, gluon fusion. Our calculation incorporates to all orders in perturbation theory two distinct towers of logarithmic corrections which are enhanced, respectively, at threshold, i.e., large x, and in the high-energy limit, i.e., small x. Large-x logarithms are resummed to next-to-next-to-next-to-leading logarithmic accuracy, while small-x ones to leading loga...

No-Go Theorem for Nonstandard Explanations of the τ→K_{S}πν_{τ} CP Asymmetry.

The CP asymmetry in τ→K_{S}πν_{τ}, as measured by the BABAR collaboration, differs from the standard model prediction by 2.8σ. Most nonstandard interactions do not allow for the required strong phase needed to produce a nonvanishing CP asymmetry, leaving only new tensor interactions as a possible mechanism. We demonstrate that, contrary to previous assumptions in the literature, the crucial interference between vector and tensor phases is suppressed by at least 2 orders of magnitude due to Watson's f...

X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes.

The new complexes [Ru(TAP)2(11-CN-dppz]2+ [Ru(TAP)2(11-Br-dppz]2+and [Ru(TAP)2(11,12-CN2-dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photooxidising complex [Ru(TAP)2(dppz)]2+ promotes π-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of lambda-[Ru(TAP)2(11-CN-dppz)]2+ with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at th...

Above and Beyond Watson and Crick: Guanine Quadruplex Structures and Microbes.

Advances in understanding mechanisms of nucleic acids have revolutionized molecular biology and medicine, but understanding of nontraditional nucleic acid conformations is less developed. The guanine quadruplex (G4) alternative DNA structure was first described in the 1960s, but the existence of G4 structures (G4-S) and their participation in myriads of biological functions are still underappreciated. Despite many tools to study G4s and many examples of roles for G4s in eukaryotic molecular processes and is...

RNA-Targeted Therapeutics.

RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are approved for commercial use for indications as diverse as Spinal Muscular Atrophy (SMA) and reduction of low-density lipoprotein cholesterol (LDL-C) and by routes of administration including subcut...

Factors Affecting the Tailing of Blunt End DNA with Fluorescent Pyrimidine dNTPs.

The transferase activity of non-proofreading DNA polymerases is a well-known phenomenon that has been utilized in cloning and sequencing applications. The non-templated addition of modified nucleotides at DNA blunt ends is a potentially useful feature of DNA polymerases that can be used for selective transformation of DNA 3' ends. In this paper, we characterized the tailing reaction at perfectly matched and mismatched duplex ends with Cy3- and Cy5-modified pyrimidine nucleotides. It was shown that the best ...

Strategies for improving the specificity of siRNAs for enhanced therapeutic potential.

RNA interference has become a tool of choice in the development of drugs in various therapeutic areas of Post Transcriptional Gene Silencing (PTGS). The critical element in developing successful RNAi therapeutics lies in designing small interfering RNA (siRNA) using an efficient algorithm satisfying the designing criteria. Further, translation of siRNA from bench-side to bedside needs an efficient delivery system and/or chemical modification. Areas covered: This review emphasizes the importance of dicer, th...

Triple-helix molecular switch-based aptasensors and DNA sensors.

Utilization of traditional analytical techniques is limited because they are generally time-consuming and require high consumption of reagents, complicated sample preparation and expensive equipment. Therefore, it is of great interest to achieve sensitive, rapid and simple detection methods. It is believed that nucleic acids assays, especially aptamers, are very important in modern life sciences for target detection and biological analysis. Aptamers and DNA-based sensors have been widely used for the design...

Surprising Sequence Effects on GU Closure of Symmetric 2 × 2 Nucleotide RNA Internal Loops.

GU base pairs are important RNA structural motifs and often close loops. Accurate prediction of RNA structures relies upon understanding the interactions determining structure. The thermodynamics of some 2 × 2 nucleotide internal loops closed by GU pairs are not well understood. Here, several self-complementary oligonucleotide sequences expected to form duplexes with 2 × 2 nucleotide internal loops closed by GU pairs were investigated. Surprisingly, nuclear magnetic resonance revealed that many of the seq...

Optimal destabilization of DNA double strands by single-nucleobase caging.

Photolabile protecting groups are widely used to trigger oligonucleotide activity. The ON/OFF-amplitude is a critical parameter. We have developed an experimental setup to identify protecting group derivatives with superior caging properties. Bulky rests are attached to the cage moiety via Cu-catalyzed azide-alkyne cycloaddition post-synthetically on DNA. Interestingly, we found that the decrease in melting temperature upon introducing o-nitrobenzyl-caged (NPBY-) and diethylaminocoumarin-cages (DEACM-) in D...


Advertisement
Quick Search
Advertisement
Advertisement