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PubMed Journals Articles About "Towers Watson" RSS

06:22 EST 10th December 2018 | BioPortfolio

Towers Watson PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Towers Watson articles that have been published worldwide.

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We have published hundreds of Towers Watson news stories on BioPortfolio along with dozens of Towers Watson Clinical Trials and PubMed Articles about Towers Watson for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Towers Watson Companies in our database. You can also find out about relevant Towers Watson Drugs and Medications on this site too.

Showing "Towers Watson" PubMed Articles 1–25 of 45

The 5-oxyacetic acid modification destabilizes double helical stem structures and favors anionic Watson-Crick like cmo5U-G base pairs.

: Watson-Crick like G-U mismatches with tautomeric Genol or Uenol bases can evade fidelity checkpoints and thereby contribute to translational errors. The 5-oxyacetic acid uridine (cmo5U) modification is a base modification at the wobble position on tRNAs and is presumed to expand the decoding capability of tRNA at this position by forming Watson-Crick like cmo5Uenol-G mismatches. A detailed investigation on the influence of the cmo5U modification on structural and dynamic features of RNA was carried out us...


ON THE COOPERATIVITY EFFECT IN WATSON&CRICK AND WOBBLE PAIRS FOR A HALOURACIL SERIES AND ITS POTENTIAL QUANTITATIVE APPLICATION STUDIED THROUGH SERS.

The nature of the cooperativity effect of hydrogen bonds in Watson & Crick and wobble base pairs formed with thymine, uracil and its 5-halogenated derivatives (5-fluoro, -chloro and -bromouracil) have been studied through SERS, and using chemometric tools to process data and extract relevant information. Remarkable differences between the two kinds of pairs were clearly observed and the behavior correlated to the withdrawing character of different substituents at the 5- position of uracil was verified. Mult...

Young children fail to generate an additive ratchet effect in an open-ended construction task.

The ratchet effect-the gradual accumulation of changes within a cultural trait beyond a level that individuals can achieve on their own-arguably rests on two key cognitive abilities: high-fidelity social learning and innovation. Researchers have started to simulate the ratchet effect in the laboratory to identify its underlying social learning mechanisms, but studies on the developmental origins of the ratchet effect remain sparse. We used the transmission chain method and a tower construction task that had...


Contributions of Jean Watson's theory to holistic critical thinking of nurses.

to reflect on the contributions of Jean Watson's theory to the nurses' holistic critical thinking.

Usefulness of Watson's Caring Science for Online Educational Practices in Disciplines Outside of Nursing.

Human caring has long been considered the primary domain of nurses and the primary function of nursing practice. Results related to the study of a Caring Science, Mindful Practice Massive Open Online Course (MOOC), suggest that Watson's Caring Science tenets are meaningful and useful for professionals who work in disciplines outside of nursing. Further study was needed to explore the degree to which Caring Science might be useful and applicable to the practices of non-nurse professionals. The study that is ...

Does the Watson-Jones or Modified Smith-Petersen Approach Provide Superior Exposure for Femoral Neck Fracture Fixation?

A well-reduced femoral neck fracture is more likely to heal than a poorly reduced one, and increasing the quality of the surgical exposure makes it easier to achieve anatomic fracture reduction. Two open approaches are in common use for femoral neck fractures, the modified Smith-Petersen and Watson-Jones; however, to our knowledge, the quality of exposure of the femoral neck exposure provided by each approach has not been investigated.

James Watson at 90.

Classifications in Brief: Watson and Ballet Classification of Scapholunate Advanced Collapse Wrist Arthritis.

Gene expression assay and Watson for Oncology for optimization of treatment in ER-positive, HER2-negative breast cancer.

Personalized treatment for cancer patients is a hot topic of debate, particularly the decision to initiate chemotherapy in patients with Estrogen receptor (ER)-positive, HER2-negative tumors in the early stages of breast cancer (BC). Owing to significant advancements in information technology (IT) and genomics, clinicians are increasingly attaining therapeutic goals rapidly and safely by effectively differentiating patient subsets that require chemotherapy. IBM Watson for Oncology (WFO) is a cognitive compu...

Gus Born: Scientific Reflections of Later Years, Inspiring the Next Generation of Blood Researchers.

I am delighted to have been be asked by Steve Watson to write a short piece for this series in Platelets, on my friendship with Prof Gus Born which began in 2011, when he came to Cardiff to present at our UK Platelets meeting. Gus was an insipiration, his story resonates today and it is an honour to have the opportunity to record a summary of our meetings here.

Novel pathway for mutagenic tautomerization of classical А∙Т DNA base pairs via sequential proton transfer through quasi-orthogonal transition states: A QM/QTAIM investigation.

In this paper we have theoretically predicted a novel pathway for the mutagenic tautomerization of the classical A∙T DNA base pairs in the free state, the Watson-Crick A·Т(WC), reverse Watson-Crick A·Т(rWC), Hoogsteen A·Т(H) and reverse Hoogsteen A·Т(rH) pairs, via sequential proton transfer accompanied by a significant change in the mutual orientation of the bases. Quantum-mechanical (QM) calculations were performed at the MP2/aug-cc-pVDZ//B3LYP/6-311++G(d,p) level in vacuum phase, along with Bad...

Energetic, topological and electric field analyses of cation-cation nucleic acid interactions in Watson-Crick disposition.

A theoretical study of the effect of the diprotonation on the nucleic acid bases (A:U, A:T and G:C) in Watson-Crick conformation has been carried out by means of DFT computational methods in vacuum. In addition, the corresponding neutral and monoprotonated binary complexes have been considered. Most of the diprotonated species studied are stable, even though the binding energy is positive due to the overall repulsive electrostatic term. Local electrostatic attractive forces in the regions of hydrogen bonds ...

Contribution of transpersonal care to cardiac patients in the postoperative period of heart surgery.

To know the contribution of Watson's theory to nursing care for cardiac patients in the postoperative period of cardiac surgery.

65 YEARS OF THE DOUBLE HELIX: Could Watson and Crick have envisioned the true impact of their discovery?

Landmark scientific findings are applauded. However, at the time of discovery, the future impact that these types of new knowledge might have on patients is not foreseen. This article discusses how unraveling the structure of DNA has advanced medical treatment, particularly for patients with rare diseases. In addition, each new scientific discovery brings with it the emotion of for improved diagnosis and treatment, as well as enhanced outcomes and increased longevity for patients facing a life-long disease...

Double Resummation for Higgs Production.

We present the first double-resummed prediction of the inclusive cross section for the main Higgs production channel in proton-proton collisions, namely, gluon fusion. Our calculation incorporates to all orders in perturbation theory two distinct towers of logarithmic corrections which are enhanced, respectively, at threshold, i.e., large x, and in the high-energy limit, i.e., small x. Large-x logarithms are resummed to next-to-next-to-next-to-leading logarithmic accuracy, while small-x ones to leading loga...

What is real success in nursing research?

Who and what can define what success is in research? With the United Kingdom's seven-yearly Research Excellence Framework and recent anniversaries such as the 40 of the Journal of Advanced Nursing providing an opportunity to look back and assess progress made and successes achieved. But how much do we do this as individual researchers?. Research success in nursing occurs mostly in a small disciplinary goldfish bowl. While the profession has progressed in terms of the number of journals, professors and volum...

No-Go Theorem for Nonstandard Explanations of the τ→K_{S}πν_{τ} CP Asymmetry.

The CP asymmetry in τ→K_{S}πν_{τ}, as measured by the BABAR collaboration, differs from the standard model prediction by 2.8σ. Most nonstandard interactions do not allow for the required strong phase needed to produce a nonvanishing CP asymmetry, leaving only new tensor interactions as a possible mechanism. We demonstrate that, contrary to previous assumptions in the literature, the crucial interference between vector and tensor phases is suppressed by at least 2 orders of magnitude due to Watson's f...

X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes.

The new complexes [Ru(TAP)2(11-CN-dppz]2+ [Ru(TAP)2(11-Br-dppz]2+and [Ru(TAP)2(11,12-CN2-dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photooxidising complex [Ru(TAP)2(dppz)]2+ promotes π-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of lambda-[Ru(TAP)2(11-CN-dppz)]2+ with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at th...

Above and Beyond Watson and Crick: Guanine Quadruplex Structures and Microbes.

Advances in understanding mechanisms of nucleic acids have revolutionized molecular biology and medicine, but understanding of nontraditional nucleic acid conformations is less developed. The guanine quadruplex (G4) alternative DNA structure was first described in the 1960s, but the existence of G4 structures (G4-S) and their participation in myriads of biological functions are still underappreciated. Despite many tools to study G4s and many examples of roles for G4s in eukaryotic molecular processes and is...

DNA surface technology - from gene sensors to integrated systems for life science and materials research.

The evolution of DNA microarray technology has led to sophisticated DNA chips that are being used as routine tools for fundamental and applied genome research such as genotyping and expression profiling. Owing to their capability for highly parallel, site-directed immobilization of complementary nucleic acids through canonical Watson-Crick base-pairing, however, DNA surfaces can as well be used for the assembly of complex surface architectures comprised of non-nucleic acid compounds, such as proteins or col...

Structural Basis of Homology-Directed DNA Repair Mediated by RAD52.

RAD52 mediates homologous recombination by annealing cDNA strands. However, the detailed mechanism of DNA annealing promoted by RAD52 has remained elusive. Here we report two crystal structures of human RAD52 single-stranded DNA (ssDNA) complexes that probably represent key reaction intermediates of RAD52-mediated DNA annealing. The first structure revealed a "wrapped" conformation of ssDNA around the homo-oligomeric RAD52 ring, in which the edges of the bases involved in base pairing are exposed to the sol...

Factors Affecting the Tailing of Blunt End DNA with Fluorescent Pyrimidine dNTPs.

The transferase activity of non-proofreading DNA polymerases is a well-known phenomenon that has been utilized in cloning and sequencing applications. The non-templated addition of modified nucleotides at DNA blunt ends is a potentially useful feature of DNA polymerases that can be used for selective transformation of DNA 3' ends. In this paper, we characterized the tailing reaction at perfectly matched and mismatched duplex ends with Cy3- and Cy5-modified pyrimidine nucleotides. It was shown that the best ...

Strategies for improving the specificity of siRNAs for enhanced therapeutic potential.

RNA interference has become a tool of choice in the development of drugs in various therapeutic areas of Post Transcriptional Gene Silencing (PTGS). The critical element in developing successful RNAi therapeutics lies in designing small interfering RNA (siRNA) using an efficient algorithm satisfying the designing criteria. Further, translation of siRNA from bench-side to bedside needs an efficient delivery system and/or chemical modification. Areas covered: This review emphasizes the importance of dicer, th...

Optimal destabilization of DNA double strands by single-nucleobase caging.

Photolabile protecting groups are widely used to trigger oligonucleotide activity. The ON/OFF-amplitude is a critical parameter. We have developed an experimental setup to identify protecting group derivatives with superior caging properties. Bulky rests are attached to the cage moiety via Cu-catalyzed azide-alkyne cycloaddition post-synthetically on DNA. Interestingly, we found that the decrease in melting temperature upon introducing o-nitrobenzyl-caged (NPBY-) and diethylaminocoumarin-cages (DEACM-) in D...

Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.

The ability to target the Cas9 nuclease to DNA sequences via Watson-Crick base pairing with a single guide RNA (sgRNA) has provided a dynamic tool for genome editing and an essential component of adaptive immune systems in bacteria. After generating a double-stranded break (DSB), Cas9 remains stably bound to DNA. Here, we show persistent Cas9 binding blocks access to the DSB by repair enzymes, reducing genome editing efficiency. Cas9 can be dislodged by translocating RNA polymerases, but only if the polymer...


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