PubMed Journals Articles About "Trigg Labs" RSS

01:03 EST 28th February 2020 | BioPortfolio

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Showing "Trigg Labs" PubMed Articles 1–25 of 74

Eight-year dry deposition of atmospheric mercury to a tropical high mountain background site downwind of the East Asian continent.

Atmospheric deposition, either dry or wet, has been identified as an important pathway of mercury (Hg) input to terrestrial and aquatic systems. Although East Asia is the major atmospheric Hg emission source region, very few studies have been conducted to quantify atmospheric Hg deposition in its downwind region. In this study, 8-year (2009-2016) atmospheric Hg dry deposition was reported at the Lulin Atmospheric Background Station (LABS), a high mountain forest site in central Taiwan. Dry deposition of spe...

Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis.

The fungal pathogen Batrachochytrium dendrobatidis (Bd) is the causative agent of chytridiomycosis and has been a key driver in the catastrophic decline of amphibians globally. While many strategies have been proposed to mitigate Bd outbreaks, few have been successful. In recent years, the use of probiotic formulations that protect an amphibian host by killing or inhibiting Bd have shown promise as an effective chytridiomycosis control strategy. The North American bullfrog (Lithobates catesbeianus) is a com...

Online volunteer laboratories for human subjects research.

Once a fixture of research in the social and behavioral sciences, volunteer subjects are now only rarely used in human subjects research. Yet volunteers are a potentially valuable resource, especially for research conducted online. We argue that online volunteer laboratories are able to produce high-quality data comparable to that from other online pools. The scalability of volunteer labs means that they can produce large volumes of high-quality data for multiple researchers, while imposing little or no fin...

Reproducibility of Indel Formation Rates by Comparing GuideRNA Format and Delivery Method.

Multiple configurations of guideRNA and Cas9 components can be used for editing cells. A few options include: a plasmid expressing both the guideRNA and Cas9, Cas9 protein combined with a synthetic single guideRNA, and Cas9 combined with a synthetic 2-part guideRNA. In addition, delivering the components to cells can be done using lipofection or nucleofection transfection methods. In the GERG 2017 survey (, plasmid format and lipofecti...

Uncovering the Underlying Mechanisms Governing the Solid-like Layering of Ionic Liquids (ILs) on Mica.

Significant progress has been made in understanding the IL-solid interface in the past three decades and a key finding is that ILs can form solid-like layers at the interface. It has been recognized that the electrostatic forces at the solid-IL interface and self-assembly of ILs are key enablers of the IL layering. However, regarding the layering structure of ILs, research from different labs are not consistent, i.e., the number of solid-like layers could range from 0 to ~60, indicating the complexity of th...

The value of preoperative labs in identifying "at-risk" patients for developing surgical site infections after pediatric neuromuscular spine deformity surgery.

This is a retrospective cohort study via a single surgeon, two-hospital database.

The infidelity of place: medical simulation labs and disjunctures in pedagogical places.

Simulations are increasingly integral to scientific and social knowledge making. While a number of social scientists study simulation, extant literature is yet to fully investigate how simulated settings are different from and similar to other scientific places. I draw on scholarship on the importance of place within knowledge making in order to study two medical simulation labs and ask what role place plays in these simulated settings. I show that effective pedagogical simulations ironically depend upon de...

Promoting the development and visibility of primary research in rehabilitation: Labs and My Rehab Thesis sessions in European Society of Physical and Rehabilitation Medicine 2018 congress.

Veterinary Student Self-Assessment of Basic Surgical Skills as an Experiential Learning Tool.

Mastery of basic skills is critical for surgical training. Such training is best obtained by experiential learning, which requires an element of self-reflection. Self-reflection is not always an automatic process, however; guidance may be required. The purpose of this study was to determine whether guided self-assessment would help facilitate student mastery of learned skills in a veterinary basic surgery course. The course consisted of 18 lectures and eight laboratories. Students were provided with written...

A Pharmacist-Led, Same-Day, HIV Pre-Exposure Prophylaxis Initiation Program to Increase PrEP Uptake and Decrease Time to PrEP Initiation.

Mississippi has one of the highest rates of HIV in the United States, but has low pre-exposure prophylaxis (PrEP) uptake, particularly among black men who have sex with men (MSM) and women. From November 2018 to May 2019, patients at high risk of HIV who tested negative for HIV at a nonclinical testing center in Jackson, Mississippi, were referred to an on-site clinical pharmacist for same-day PrEP initiation. The pharmacist evaluated patients for medical contraindications to PrEP, but no baseline labs were...

Online Patient Portal Use and Time to Renal Transplantation in Patients on Hemodialysis.

Online portals have been shown to be a valuable tool for patients to improve compliance with medical treatments in numerous studies across medical specialties. Our aim was to study the effects of the use of web- based applications that allow patients to track their appointments, labs, and provider visit notes on achievement of renal transplantation.

Palladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines.

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical labs in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions.

Data to Care Opportunities: An Evaluation of Persons Living With HIV Reported to Be "Current to Care" Without Current HIV-Related Labs.

Data to care (D2C) is an effective strategy using HIV surveillance data to link/relink persons living with HIV into medical care. However, some appearing to be not in care (NIC) report being in care (persons "current to care").

What happens before the first step? A New Approach to Quantifying Gait Initiation Using a Wearable Sensor.

Walking is a volitional behavior that requires planning and initiation before a step is observed. Following a signal to begin walking, studies of gait initiation in specialized labs have identified three phases that occur during the transition from a standing position via anticipatory postural adjustment (APA) to the first step. Routine instrumented gait testing outside of the laboratory setting focuses on gait execution and does not include gait initiation measures.

Data denoising with transfer learning in single-cell transcriptomics.

Single-cell RNA sequencing (scRNA-seq) data are noisy and sparse. Here, we show that transfer learning across datasets remarkably improves data quality. By coupling a deep autoencoder with a Bayesian model, SAVER-X extracts transferable gene-gene relationships across data from different labs, varying conditions and divergent species, to denoise new target datasets.

Long Term Prevention and Vector Control of Arboviral Diseases: What does the future hold?

Arboviral diseases are a global growing problem due to climate change, urbanization, population density, global transportation. However, new technologies currently being developed in research labs are expected to play a relevant role in combatting arboviral diseases in the future, reducing the health and economic burden imposed by these diseases.

The Rapidly Changing US Illicit Drug Market and the Potential for an Improved Early Warning System: Evidence from Ohio Drug Crime Labs.

The US has seen a rapid increase in synthetic opioid-related overdose deaths. We investigate Ohio, a state with one of the highest overdose death rates in 2017 and substantial numbers of deaths related to fentanyl, carfentanil, and other fentanyl analogs, to provide detailed evidence about the relationship between changes in the illicit drug market and overdose deaths.

Animal models for Lassa virus infection.

In humans, Lassa virus infection can result in disease with hemorrhagic manifestations and high fatality rates. There are no approved treatments or vaccines available and the inherent danger of studying Lassa virus means it can only be studied in high containment labs (BSL4). Under these conditions, mouse models are becoming an important instrument in the study of Lassa virus infection, disease and host responses. While guinea pigs and non-human primates are the critical components in assessing treatments a...

Vitamin D and depression: mechanisms, determination and application.

Depression is the most common debilitating psychiatric disease, the pathological mechanisms of which are associated with multiple aspects of neural function. While recent evidence has consistently suggested that a suboptimal vitamin D status is frequently observed in patients with depression, the results concerning whether vitamin D insufficiency is a causal factor of depression or is secondary to depressive behavior are conflicting; additionally, the lack of consistency of the method of vitamin D determina...

The Ras switch in structural and historical perspective.

Since its discovery as an oncogene more than 40 years ago, Ras has been and still is in the focus of many academic and pharmaceutical labs around the world. A huge amount of work has accumulated on its biology. However, many questions about the role of the different Ras isoforms in health and disease still exist and a full understanding will requiremore intensive work in the future. Here we try to survey some of the structural findings in a historical perspective and how it has influenced our understanding ...

Communication to cure cath chaos.

Communication errors in the cath lab may lead to incorrect medication administration or dosing, or incorrect sizes of devices deployed in patients, with catastrophic results. Use of closed-loop communication minimizes these errors. In this study, two rounds of quality improvement projects improved, but did not completely close the communication gap. Standard setting by professional societies and individual cath lab leaders may be necessary to improve the use of closed-loop communication in cath labs-althoug...

A simple model for determining affinity from irreversible thermal shifts.

Thermal denaturation (Tm) data are easy to obtain; it is a technique that is used by both small labs and large-scale industrial organizations. The link between ligand affinity (Kd) and ΔTm is understood for reversible denaturation; however, there is a gap in our understanding of how to quantitatively interpret ΔTm for the many proteins that irreversibly denature. To better understand the origin, and extent of applicability, of a Kd to ΔTm correlate, we define equations relating Kd and ΔTm for irreversib...

Fomepizole as an adjunctive treatment in severe acetaminophen toxicity: A case report.

A 33-year-old male presented to the emergency department with a chief complaint of abdominal pain after taking #50 500 mg acetaminophen tablets over the preceding two days. He was tachycardic and tachypneic, and the initial labs were notable for acetaminophen level, 337 mg/L; AST, 137 IU/L; ALT, 194 IU/L; ABG pH, 7.24; and lactate, 4.1 mmol/L. The patient was started on IV N-Acetylcysteine (NAC) as well as given a single dose of 15 mg/kg fomepizole. The patient did remarkably well, with a peak AST of ...

Use of a dilatable exGraft™ conduit in single ventricle palliation.

Surgically-paced prosthetic conduits are commonly used in the treatment of congenital heart disease. A major limitation of available prosthetic grafts is that they do not grow with the patient. We describe the first human case of percutaneous balloon dilation of a surgically placed exGraft conduit (PECA labs, Inc. Pittsburgh, PA) in a neonate with single ventricle disease. The use of dilatable conduits could change the management of many congenital heart defects and significantly reduce both the morbidity o...

Luminal A versus B breast cancer: MammaTyper® mRNA versus immunohistochemical subtyping with emphasis on standardised Ki67-Labelling or Mitotic Activity Index based proliferation assessment.

Proliferation assessment using Ki67 is a crucial component in intrinsic subtyping of luminal breast cancers (BC) but suffers from variability between labs, observers and methods. MammaTyper is a quantitative molecular tool that measures mRNA levels of the ERBB2, ESR1, PGR and MKI67 genes in BC, and interprets the results according to the St Gallen 2013 consensus recommendations. We compared MammaTyper with immunohistochemistry (IHC) based subtypes with focus on standardised proliferation assessment.

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