Topics

PubMed Journals Articles About "Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium" RSS

21:16 EDT 2nd April 2020 | BioPortfolio

Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium articles that have been published worldwide.

More Information about "Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium" on BioPortfolio

We have published hundreds of Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium news stories on BioPortfolio along with dozens of Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium Clinical Trials and PubMed Articles about Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium Companies in our database. You can also find out about relevant Ultrasonic Waves Effect Shaped Amyloids Conformational Dynamics Equilibrium Drugs and Medications on this site too.

Showing "Ultrasonic waves effect shaped amyloids conformational dynamics equilibrium" PubMed Articles 1–25 of 27,000+

Ultrasonic waves effect on S-shaped β-amyloids conformational dynamics by non-equilibrium molecular dynamics.

Ultrasound-based technologies are widely adopted in the clinical practice. Recently, the ultrasound stable cavitation has been proposed as a strategy to destabilize amyloid aggregates in Alzheimer disease. However, the molecular mechanisms driving ultrasound-induced amyloid destabilization are not fully clarified yet. Here, molecular dynamics is applied to investigate in silico the conformational dynamics induced by ultrasound stable cavitation on S-shaped Aβ1-42 amyloid fibrils, which has been highlighted...


Single-step sonochemical synthesis of CuO-CeO nanocomposites with enhanced photocatalytic oxidative desulfurization.

In this paper, for the first time, composite nanostructures of CuO-CeO were prepared by a facile and single-step sonochemical method for thiophene photocatalytic oxidative desulfurization. Sonication was performed utilizing a high-intensity ultrasonic probe with a maximum output power of 80 Wcm and operating frequency at 20 kHz. The direct effect of ultrasonic waves on the composition and morphology of the obtained products was also evaluated and it was found that under ultrasonic irradiation, CuO-CeO can ...

An investigation of the effect of ultrasonic waves on the efficiency of silicon extraction from coal fly ash.

Burning of coal accounts for an enormous proportion of the current energy supply, especially in developing countries. Burning of coal produces large amounts of coal fly ash, which causes serious environmental problems unless it is managed properly. Using chemical analysis, we found that coal fly ash could be a promising source of Si, Al, Ca and some rare earth elements, especially with the assistance of some measures such as ultrasound. In this study, we extracted silicon from coal fly ash using an alkaline...


The Role of Displacing Confined Solvent in the Conformational Equilibrium of β-Cyclodextrin.

This study investigates the role of hydration and its relationship to the conformational equilibrium of the host molecule β-cyclodextrin. Molecular dynamics simulations indicate that the unbound β-cyclodextrin exhibits two state behavior in explicit solvent due to the opening and closing of its cavity. In implicit solvent, these transitions are not observed and there is one dominant conformation of β-cyclodextrin with an open cavity. Based on these observations, we investigate the hypothesis that the exp...

Ultrasonic Lamb waves for wireless power transfer.

Ultrasonic guided plate waves (Lamb waves) can be used to transfer power along the length of metal plates, achieving longer distance wireless power transfer while not being impeded by electromagnetic shielding from the metal plate. In this paper, a fundamental study on the performance of Lamb wave wireless power transfer is presented, including modeling, simulations, and experimental verification. By using Macro-Fiber Composite (MFC) d33 mode piezoelectric transducers bonded to a 64 mmx406 mmx1.6 mm aluminu...

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing.

Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium between a single- and a two-nucleotide bulge conformation, which is directly linked to a switch between sugar puckers of the branch site adenosine. Our study determined a functional sugar pucker equilibrium between the transesterification active C2'-endo confo...

Numerical study on dual-frequency ultrasonic enhancing cavitation effect based on bubble dynamic evolution.

Ultrasonic cavitation is a physical dynamic phenomenon of bubbles inflation, compression, and collapse in liquid. A dual-frequency ultrasonic cavitation dynamics model is established in this paper to investigate dynamic evolution of bubble under single and dual frequency ultrasonic modes. The variation of bubble radius, pressure, energy, temperature, and number of water vapor molecules inside the bubble in single and dual frequency ultrasonic modes are analyzed, respectively. The results show the oscillatio...

Transmission of Images with Ultrasonic Elastic Shear Waves on a Metallic Pipe using Amplitude Shift Keying Protocol.

Transmission of information using ultrasonic elastic waves on existing metallic pipes provides an alternative communication option across physical barriers in a highly partitioned industrial complex, such as a nuclear facility. This work investigates feasibility of transmission of digital images over metallic pipes. Ultrasonic communication systems for transmission of images on a nuclear-grade stainless steel pipe was assembled for bench scale demonstration. Information carriers in this system are refracted...

Ultrasonic-assisted preparation and characterization of hierarchical porous carbon derived from garlic peel for high-performance supercapacitors.

Ultrasonic-assisted impregnation is used to synthesize physically modified garlic peel-based 3D hierarchical porous carbons (PCs), and the effect on PCs is investigated by changing ultrasonic time. The results show that ultrasonic waves can effectively peel off surface attachments of the carbonized product, so that activator has a better mass transfer process and create more active sites. The connectivity of 3D pore network is enhanced as well, so the structure and electrochemical properties of garlic peel-...

Temperature affected guided wave propagation in a composite plate complementing the Open Guided Waves Platform.

The influence of temperature is regarded as particularly important for a structural health monitoring system based on ultrasonic guided waves. Since the temperature effect causes stronger signal changes than a typical defect, the former must be addressed and compensated for reliable damage assessment. Development of new temperature compensation techniques as well as the comparison of existing algorithms require high-quality benchmark measurements. This paper investigates a carbon fiber reinforced plastic (C...

Strong Adverse Contribution of Conformational Dynamics to Streptavidin-Biotin Binding.

Molecular dynamics plays an important role for the biological function of proteins. For protein ligand interactions, changes of conformational entropy of protein and hydration layer are relevant for the binding process. Quasielastic neutron scattering (QENS) was used to investigate differences in protein dynamics and conformational entropy of ligand-bound and ligand-free streptavidin. Protein dynamics were probed both on the fast picosecond timescale using neutron time-of-flight spectroscopy and on the slow...

Conformational Entropy as a Means to Control the Behavior of Poly(diketoenamine) Vitrimers In and Out of Equilibrium.

Poly(diketoenamine) (PDK) vitrimers are an emerging platform for sustainable plastics, providing additive-tolerant chemical circularity after depolymerization.  Here we show how to control the equilibrium and non-equilibrium thermomechanical behavior of PDKs by incorporating into the dynamic covalent network linear polymer segments varying in both molecular weight ( MW = 0-12 kg mol -1 ) and conformational degrees of freedom. While increasing  MW of linear segments predictably yields a lower storage modu...

Computational Study on Structure and Aggregation Pathway of Aβ Amyloid Protofibril.

Amyloid deposits of Aβ protein in neuronal cells are known to be a major symptom of Alzheimer's disease. In particular, Aβ shows relatively high toxicity among the different Aβ isoforms, and its toxicity is thought to be because of its structural features. Recent ssNMR and cryo-EM experiments identified that Aβ shows an S-shaped triple-β structure, in contrast to the previously suggested U-shaped β-arch structure. In order to associate the high toxicity of Aβ with its structural features, it is essen...

Ultrasonic seed treatment improved cadmium (Cd) tolerance in Brassica napus L.

Cadmium (Cd) affects crop growth and productivity by disrupting normal plant metabolism. To determinate whether ultrasonic (US) seed treatment can alleviate Cd stress in rape (Brassica napus L.), the seeds of two oilseed rape cultivars i.e., 'Youyanzao18' and 'Zaoshu104' were exposed to ultrasonic waves for 1 min at 20 KHz frequency. Seeds without US treatment were taken as control (CK). Results revealed that the germination rate of both cultivars was significantly (P 

Revealing the positive binding cooperativity mechanism between the orthosteric and the allosteric antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations.

CC chemokine receptor 2 (CCR2) and its endogenous CC chemokine ligands are associated with numerous inflammatory, neurodegenerative diseases, and cancer. CCR2 is becoming an attractive target in the treatment of autoimmune disease and neurodegenerative diseases. The orthosteric antagonist BMS-681 and allosteric antagonist CCR2-RA-[R] of CCR2 show positive binding cooperativity. We performed well-tempered metadynamics simulation and Gaussian accelerated MD simulations to reveal the influence of the orthoster...

Air coupled ultrasonic inspection with Lamb waves in plates showing mode conversion.

In this paper we demonstrate a non-destructive, non-contact detection method for small defects in thin polymer plates using an air coupled ultrasonic (ACUS) setup. There exist many applications for such methods, e.g. quality control in the manufacturing process or failure prevention by periodical inspections during the lifetime of a product. We demonstrate a setup for the inspection of plates together with signal analysis algorithms to process the measured data, meeting the challenges to handle the dispersi...

Spiral-Shaped Biologically-Inspired Ultrasonic Sensor.

Up to now, low frequency ultrasonic transducers have been manufactured using different materials and technologies, and have been inspired by the biological world, mainly by the biosonar of dolphins and bats. Our research moves in this context which is dedicated to investigate the feasibility of developing a piezopolymer sensor capable of covering the wide frequency range of a bat-s biosonar. We propose an ultrasonic sensor manufactured using a sheet of Polyvinylidene Fluoride curved according to a logarithm...

State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states.

The brainstem plays a crucial role in sleep-wake regulation. However, their ensemble dynamics underlying sleep regulation remain poorly understood. Here we show slow, state-predictive brainstem ensemble dynamics and state-dependent interactions between the brainstem and the hippocampus in mice. On a timescale of seconds to minutes, brainstem populations can predict pupil dilation and vigilance states where they exhibit longer predictable power compared with hippocampal CA1 neurons. On a timescale of sub-sec...

Comparing the Conformational Stability of Pyruvate Kinase in the Gas Phase and in Solution.

Collision induced unfolding (CIU) is increasingly used to characterize protein complexes in the gas phase and is often employed to detect ligand binding-induced conformational stabilization. However, the extent to which gas-phase conformational stabilities measured by CIU reflect analogous parameters in solution is not yet clear, particularly for systems where conformational and protein complex stability are modulated by point mutation. Here, we compare CIU-derived relative stabilities of four point mutants...

Ex-vivo assessment of cortical bone properties using low-frequency ultrasonic guided waves.

The early diagnosis of osteoporosis through bone quality assessment is a major public health challenge. Research in axial transmission using ultrasonic guided waves has shown the method to be sensitive to the geometrical and mechanical properties of the cortical layer in long bones. However, because of the asymmetric nature of cortical bone, the introduction of a more elaborate numerical model than the analytical plate and cylinder models, as well as its inversion, continue to be challenging. The aim of thi...

Exploring Conformational Transitions and Free Energy Profiles of Proton Coupled Oligopeptide Transporters.

Proteins involved in peptide uptake and transport belong to the proton-coupled oligopeptide transporter (POT) family. Crystal structures of POT family members reveal a common fold consisting of two domains of six transmembrane α helices that come together to form a "V"shaped transporter with a central substrate binding site. Proton coupled oligopeptide transporters operate through an alternate access mechanism, where the membrane transporter undergoes global conformational changes, alternating between inwa...

Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase.

The effect of molecular crowding on the structure and function of Escherichia coli prolyl-transfer RNA synthetase (Ec ProRS), a member of the aminoacyl-transfer RNA synthetase family, has been investigated using a combined experimental and theoretical method. Ec ProRS is a multidomain enzyme; coupled-domain dynamics are essential for efficient catalysis. To gain insight into the mechanistic detail of the crowding effect, kinetic studies were conducted with varying concentrations and sizes of crowders. In pa...

Arrowhead design ultrasonic tip as a supplementary tool for canal debridement.

To investigate the shaping and cleaning performance of the Clearsonic ultrasonic tip as a supplementary tool during the preparation of long oval-shaped root canals through micro-computed tomographic (micro-CT) imaging technology. Reciproc M-Wire R40 instrument was used as a reference instrumentation technique for comparison.

Dynamics of Cation-Induced Conformational Changes in Nanometer-Sized Uranyl Peroxide Clusters.

Conformational changes of the pyrophosphate (Pp)-functionalized uranyl peroxide nanocluster [(UO)(O)(PO)] ({UPp}), dissolved as a Li/Na salt, can be induced by the titration of alkali cations into solution. The most symmetric conformer of the molecule has idealized octahedral () molecular symmetry. One-dimensional P NMR experiments provide direct evidence that both K and Rb ions trigger an -to- conformational change within {UPp}. Variable-temperature P NMR experiments conducted on partially titrated {UPp} s...

Research on the removal of near-well blockage caused by asphaltene deposition using sonochemical method.

Near-well blockage caused by asphaltene deposition often occurs during the process of crude oil exploitation. It can reduce the porosity and permeability of reservoirs and seriously affects the migration and exploitation of oil and gas. In this paper, removing near-well blockage caused by asphaltene deposition using sonochemical method is investigated. Six PTZ transducers with different parameters are used to study the deplugging effect. Results show that the optimal ultrasonic frequency and power for plugg...


Quick Search