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PubMed Journals Articles About "Variation Cell Population Granulomas Immunocompetent Immunosuppressed Rabbits Encephalitozoon" RSS

20:36 EST 25th January 2020 | BioPortfolio

Variation Cell Population Granulomas Immunocompetent Immunosuppressed Rabbits Encephalitozoon PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Variation Cell Population Granulomas Immunocompetent Immunosuppressed Rabbits Encephalitozoon articles that have been published worldwide.

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Showing "Variation cell population granulomas immunocompetent immunosuppressed rabbits Encephalitozoon" PubMed Articles 1–25 of 36,000+

Variation of the CD4, CD8, and MHC II cell population in granulomas of immunocompetent and immunosuppressed rabbits in Encephalitozoon cuniculi infection.

Encephalitozoon cuniculi (E. cuniculi) is a fungi-related, obligate, zoonotic, spore-forming intracellular eukaryotic microorganism. This emerging pathogen causes granulomas in brain and kidneys of infected individuals. The objective of this study was to detect the distribution of CD4, CD8 and MHCII-positive cells within granulomas in these organs in infected immunocompetent (group A) and infected immunosuppressed (group B) New Zealand white rabbits using immunohistochemistry. In brain, labeled CD4 immune c...


Influence of the interaction between cysticercosis and obesity on rabbit behavior and productive parameters.

Parasites induce behavioral changes in the host and obesity is a health problem affecting different animal species. Cysticercosis caused by Taenia pisiformis affects some behavior of rabbits and reproductive behavior of does. Rabbits do not escape from metabolic disorders, being long-live animals useful in breeding, research and companion animals. Here, we addressed the interaction between parasitosis and obesity, and studied how these conditions or the comorbidity affect behavioral and productive parameter...

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.

Rabbits with naturally high levels of cholesterol ester transfer protein (CETP), unlike rodents, have become an interesting animal model for the study of lipid metabolism and atherosclerosis, as they have similarities to humans in lipid metabolism, cardiovascular physiology and susceptibility to develop atherosclerosis. Rodents, such as mice, are not prone to atherosclerosis as they lack the mass and activity of CETP, as a key player in lipoprotein metabolism. Recently, APOE-knockout in rabbits has been sho...


Nocardiosis as a Differential Diagnosis of Pulmonary Epitheloid Cell Granulomas.

A 47-year-old man presented with fever, weight loss and pulmonary consolidations and cavitation in the x-ray of the thorax. The comprehensive diagnostics resulted pulmonary epitholoid cell granulomas, therefore an immunosuppressive therapy was applied on suspicion of sarcoidosis. Progressivly the pulmonary infiltration increased and cerebral and abdominal abscesses were determined with microbiological detection of Nocardia farcinica. Despite antibiotic therapy, the patient died in a septic shock with multip...

Clinical Significance of Granulomas in Crohn's Disease: A Systematic Review and Meta-analysis.

Epithelioid granuloma is one hallmark used to histologically diagnose Crohn's disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas.

Heterogeneous alpha-cell population modeling of glucose-induced inhibition of electrical activity.

Glucagon release from the pancreatic alpha-cells is regulated by glucose, but the underlying mechanisms are far from understood. It is known that the alpha-cell population is very heterogeneous, but - compared to the insulin-secreting beta-cells - the consequences of this cell-to-cell variation are much less studied. Since the alpha-cells are not electrically coupled, large differences in the single cell responses are to be expected, and this variation may contribute to the confusion regarding the mechanism...

Genetic diversity and population structure of four Chinese rabbit breeds.

There are a few well-known indigenous breeds of Chinese rabbits in Sichuan and Fujian provinces, for which the genetic diversity and population structure have been poorly investigated. In the present study, we successfully employed the restriction-site-associated DNA sequencing (RAD-seq) approach to comprehensively discover genome-wide SNPs of 104 rabbits from four Chinese indigenous breeds: 30 Sichuan White, 34 Tianfu Black, 32 Fujian Yellow and eight Fujian Black. A total of 7,055,440 SNPs were initially ...

Surgical resolution of uterine prolapse in three pet rabbits.

This report describes a surgical technique for resolution of uterine prolapse in rabbits. Three pet rabbits presented within 24 hours of parturition with a red mass protruding from the vagina, which was diagnosed as uterine prolapse. In the first case, an attempt to reduce the prolapse by manual compression was ineffective. A laparotomy was used to apply internal uterine traction while simultaneously using gentle external pressure with cotton-tip applicators and resulted in successful resolution. After re...

Rubella Vaccine Persistence Within Cutaneous Granulomas in Common Variable Immunodeficiency Disorder.

Common variable immunodeficiency disorder is a primary immunodeficiency disorder characterized by reduced levels of serum immunoglobulins and impaired antibody response. This condition may be associated with development of noninfectious granulomatous dermatitis of the skin which may be disfiguring and destructive. There are no published guidelines for the treatment of cutaneous granulomas in this patient population. In recent studies, rubella virus-positive cells in granulomas were localized to M2 macrophag...

Control over single-cell distribution of G1 lengths by WNT governs pluripotency.

The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials toward either neuroectoderm or mesendoderm depending on their G1 lengths before the onset of differentiation. Single-cell variation in G1 length operates in a dynamic equilibrium that establish...

Comparison of Seroprevalence and PCR Results in the Detection of in Pet Rabbits in Poland.

infections are prevalent in humans and animals worldwide. The aim of the study was to estimate the seroprevalence of in pet rabbits, as well the presence of DNA in their blood. A total of 360 pet rabbits were investigated for the presence of antibodies and antigens of in blood samples using a modified agglutination test (MAT) and nested PCR, respectively. Antibodies against were found in 44 (12.12%) of pet rabbits. In rabbits that received unwashed vegetables 13.13% were positive for antibodies, wherea...

Screening of opportunistic Encephalitozoon intestinalis and Enterocytozoon bieneusi in immunocompromised patients in Slovakia.

In recent years new infectious diseases, i.e. emerging or re-emerging diseases, have been coming to the forefront. Currently, microsporidia, considered to be a major cause of emerging and opportunistic infections particularly in immunocompromised individuals, are also included in this group. Therefore, the aim of our study was to map the prevalence of Encephalitozoon intestinalis and Enterocytozoon bieneusi infection in a group of patients and to compare it with the occurrence of specific antigens in immuno...

Molecular epidemiology of Enterocytozoon bieneusi and Encephalitozoon sp., among immunocompromised and immunocompetent subjects in Iran.

Intestinal microsporidiosis is known as an opportunistic infection in immunocompromised patients. The current study aimed to investigate intestinal microsporidia infection in human subjects with/without immunodeficiency. Totally, 600 stool samples were collected from immunocompromised (254) and immunocompetent (346) subjects. DNA extraction was performed and the SSU rRNA and ITS genes were amplified to detect and characterize microsporidia and the relevant genotypes. Phylogenetic trees were drawn using MEGA...

Evaluation of treatment modalities for contact granulomas.

There are merely heterogenous therapy modalities for contact granulomas (CG) without evidenced efficacy. The intention of our study was to evaluate possible risk factors as well as to demonstrate therapeutic successful approaches.

Disseminated Tubercular Granulomas Associated with the Use of Azathioprine.

: To describe a case of multiple disseminated choroidal tuberculomas in a patient of early-phase Vogt-Koyanagi- Harada (VKH) disease being treated with Azathioprine.: A retrospective chart review.: A 55-year-old female, a diagnosed case of VKH disease, was being treated with oral steroids and Azathioprine. During one of her follow-up visit, she was detected with multiple subretinal granulomas with surrounding fluid in both eyes. Fundus fluorescein angiography (FFA), Indocyanine green angiography (ICGA) and ...

Morbidity and mortality of domestic rabbits () under primary veterinary care in England.

The domestic rabbit is a common pet species, but limited research exists on the health of pet rabbits. This study aimed to characterise common disorders of pet rabbits and reasons for mortality as recorded by veterinary practices in England.

Iatrogenic immunodeficiency-associated lymphoproliferative disorder in a child with B-cell acute lymphoblastic leukemia.

Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are a group of lymphoid proliferations or lymphomas that are well known to be associated with an immunosuppressed state. These disorders most commonly occur following hematopoietic or solid organ transplantation (called post-transplant lymphoproliferative disorders or PTLD), but cases have also been described during the treatment of autoimmune and rheumatologic disorders by immunosuppressive and immunomodulatory medications. These d...

High content analysis of granuloma histology and neutrophilic inflammation in adult zebrafish infected with Mycobacterium marinum.

Infection of zebrafish with natural pathogen Mycobacterium marinum is a useful surrogate for studying the human granulomatous inflammatory response to infection by Mycobacterium tuberculosis. The adaptive immune system of the adult stage zebrafish offers an advance on the commonly used embryo infection model as adult zebrafish form granulomas with striking similarities to human-M. tuberculosis granulomas. Here, we present workflows to perform high content analyses of granulomas in adult zebrafish infected w...

Bacillus Calmette-Guérin in Immunosuppressed Patient with High-Grade Nonmuscle Invasive Bladder Carcinoma.

Due to their immunosuppressed status, solid organ transplant recipients are a special group of patients with an incidence of bladder cancer greater than the rest of the population, especially in the first 6 years after transplantation. Also, treatment with Bacillus Calmette-Guérin, a reference therapy in nonmuscle invasive high-risk bladder cancer, may be less effective in this group of patients and could cause more adverse effects. However, the data published so far and the experience initiated in the Vir...

Mesenteric granulomas independently predict long-term surgical recurrence risk in Crohn's disease.

Risk factors predicting surgical recurrence in Crohn's disease (CD) remain controversial. Postoperative anti-TNF therapy might lower recurrence rates whilst presence of mesenteric granulomas has been postulated as a risk factor. We hypothesized that mesenteric granulomas indicate disease severity and might predict surgical recurrence risk, irrespective of immunosuppressive therapy.

Effect of Lentinan on Peyer's patch structure and function in an immunosuppressed mouse model.

Lentinan (LNT), a polysaccharide isolated from Lentinus edodes, has been shown to stimulate immune response. Despite its widespread use owing to its health benefits, epidemiologic and experimental studies that address the biological activities of LNT after oral administration to animals or humans are rare. In this study, the effects of LNT on the intestinal mucosal immune system of immunosuppressed mice were investigated. The number and size of the Peyer's patches (PPs), proliferation ability of PP lymphocy...

Transcriptome variation in human populations and its potential application in forensics.

This review presents the state-of-the-art in the forensic application of genetic methods driven by the research in population transcriptomics. In the first part of the review, the constraints of using classical genomic markers are shortly reviewed. In the second part, the developments in the field of inter-population diversity at the transcriptomic level are presented. Subsequently, a potential of population-specific transcriptomic markers in forensic science applications, including ascertaining population ...

Mycobacterium abscessus bloodstream infection: unexpected catheter tunnel infection localised by PET/CT.

Mycobacterium abscessus is an emerging cause of invasive infection in the immunosuppressed population. We report a case of M. abscessus bloodstream and catheter tunnel infection localised by positron emission tomography/computer tomography (PET/CT) in an allogeneic haematopoietic stem cell transplant recipient. This case highlights the difficulties in treating invasive M. abscessus infection and the potential role of PET/CT in localising infection and guiding therapy in this population. This article is prot...

Analyzing and interpreting spatial and temporal variability of the United States county population distributions using Taylor's law.

We study the spatial and temporal variation of the human population in the United States (US) counties from 1790 to 2010, using an ecological scaling pattern called Taylor's law (TL). TL states that the variance of population abundance is a power function of the mean population abundance. Despite extensive studies of TL for non-human populations, testing and interpreting TL using data on human populations are rare. Here we examine three types of TL that quantify the spatial and temporal variation of US coun...

Sun protection factor reimbursement as a means to promote increased usage in an organ transplant recipient population.

Skin cancers, in particular keratinocyte cancers(KCs) are the commonest malignancies seen in immunosuppressed organ transplant recipients(OTRs) . These patients, when compared to the general population are at increased risk of cutaneous malignancies, with sun exposure a major risk factor.


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