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PubMed Journals Articles About "Zeta Potential Changing Polyphosphate Nanoparticles Promising Approach Overcome" RSS

17:28 EST 14th November 2019 | BioPortfolio

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Showing "Zeta Potential Changing Polyphosphate Nanoparticles promising approach overcome" PubMed Articles 1–25 of 41,000+

Zeta Potential Changing Polyphosphate Nanoparticles: A promising approach to overcome the mucus and epithelial barrier.

The aim of the present study was to develop zeta potential changing polyphosphate nanoparticles (pp-NPs) in order to overcome the diffusion barrier of the mucus gel layer and to provide an enhanced cellular uptake.


Zeta potential changing self-emulsifying drug delivery systems: A promising strategy to sequentially overcome mucus and epithelial barrier.

The aim of the present study was to develop zeta potential changing self-emulsifying drug delivery systems (SEDDS) via a flip-flop mechanism in order to improve their mucus permeating and cellular uptake properties.

Dexamethasone-loaded PLGA-nanoparticles for potential local treatment of oral precancerous lesions.

The aim of this study was to develop dexamethasone loaded nanoparticles for the local treatment of oral precancerous lesions. Dexamethasone loaded nanoparticles were prepared using the emulsification/solvent evaporation method. The prepared nanoparticles were characterised for pH, particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency and drug loading. Furthermore, drug release, stability, drug diffusion and cell culture studies were undertaken. The particle size, polydi...


Carbamide peroxide nanoparticles for dental whitening application: Characterization, stability and in vivo/in situ evaluation.

Carbamide peroxide is the popular home dental whitening agent. However, it has critical stability. Nanoparticles have been applied to develop products with advantages properties as better efficacy and stability increase. The aim of this study was the characterization of carbamide peroxide polymeric nanoparticles, their bleaching efficacy, effects on pulp damage and stability evaluation. Particle size demonstrated a spherical morphology and bimodal distribution (11 and 398 nm). Nanoparticles presented high...

Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi.

Nanoparticle based siRNA formulations often suffer from aggregation and loss of function during storage. We in this study report a frozen targeted RGD-polyethylene glycol (PEG)-ECO/siβ3 nanoparticle formulation with a prolonged shelf life and preserved nanoparticle functionality. The targeted RGD-PEG-ECO/siβ3 nanoparticles are formed by step-wised self-assembly of RGD-PEG-maleimide, ECO, and siRNA. The nanoparticles have a diameter of 224.5 ± 9.41 nm and a zeta potential to 45.96 ± 3.67 mV i...

Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid.

The objective of this study was to develop zein-casein-lysine nanoparticles to modulate the intestinal permeability of ferulic acid (FA), a bioactive compound with proven antioxidant properties. The nanoparticles were obtained by a liquid-liquid dispersion method and were characterized in terms of mean size, polydispersity index, zeta potential, association efficiency (AE), in vitro drug release, x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The in vitro intestinal permeabilit...

Black rice anthocyanins embedded in self-assembled chitosan/chondroitin sulfate nanoparticles enhance apoptosis in HCT-116 cells.

Self-assembled nanoparticles using the biopolymers chitosan (CH) and chondroitin sulfate (CS) were developed to improve the biological activity of anthocyanin (ACN). The 86.32 ± 0.15% (w/w) of ACN was incorporated into ACN/CH/CS nanoparticles, with the particle size of 350.1 ± 0.99 nm in diameter (i.d.) and 42.55 ± 0.54 in zeta potential (mV). Morphological study and thermogravimetric analysis suggested that the ACN/CH/CS nanoparticles exhibited heterogeneous morphology and high thermal sta...

New approaches to tumour therapy with siRNA-decorated and chitosan-modified PLGA nanoparticles.

In this study, we aimed to develop a candidate polymeric nanoparticle system that will kill cancer cells by taking them to apoptosis and also reduce pain. The primary goal of treatment, especially for metastatic cancers, is to control the growth of the cancer and to alleviate the symptoms. Pain is one of the commonest symptoms of cancer. In cancer treatment, directing cancer cells to death while simultaneously relieving pain will be a new approach. Chitosan-modified PLGA nanoparticles were prepared using ...

A novel theranostic system of AS1411 aptamer-functionalized albumin nanoparticles loaded on iron oxide and gold nanoparticles for doxorubicin delivery.

Recently DNA aptamers have attracted remarkable attention as possible targeting ligands since selective targeting of cancer cells is a critical step in cancer diagnosis and therapy. Here, the development of AS1411 aptamer-functionalized albumin nanoparticles loaded on iron oxide and gold nanoparticles is reported for target delivery of the well-known anticancer drug of doxorubicin (Dox). Iron oxide nanoparticles (IONPs) and gold nanoparticles (GNPs) were prepared by ultrasound-assisted and controlled seeded...

Chitosan based micelle with zeta potential changing property for effective mucosal drug delivery.

Mucus permeation, mucoadhesion and cell membrane interaction are properties that a drug carrier needs to deliver macromolecule compounds through the mucus barrier and inside epithelial cells effectively. Herein, we prepared micelles from phosphorylated chitosan-stearic acid conjugates (CSSAP) possessing those properties. Their zeta potential can be shifted from negative to neutral once contacting with alkaline phosphatase (ALP). CSSAP micelles showed effective mucus permeation and cell association, thus cou...

Cellular uptake and transport characteristics of chitosan modified nanoparticles in Caco-2 cell monolayers.

The bioadhesive drug delivery systems, chitosan modified nanoparticles, can efficiently adhere to mucosal surface of gastrointestinal tract and prolong residence time but a deeper understanding about its cellular uptake and transport is still lack. Hence, the present study was designed to compare the process of uptake and transport between chitosan modified and unmodified PLGA nanoparticles. Chitosan modified nanoparticles were formulated by classic and chemical methods. The morphology and modification pote...

Class III polyphosphate kinase 2 enzymes catalyze the pyrophosphorylation of adenosine-5'-monophosphate.

Polyphosphate kinase 2 (PPK2) transfer phosphate from inorganic polyphosphate to nucleotides. According to their activity, PPK2 enzymes are classified into three groups. Among them, class III enzymes catalyze both the phosphorylation of nucleotide mono- to di-phosphates and di- to tri-phosphates using polyphosphate which is a very inexpensive substrate. Therefore, class III enzymes are very attractive for use in biotechnological applications. Despite several studies on class III enzymes, the detailed mechan...

Curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS): a promising approach for the control of primary pathogen and secondary bacterial infections in cutaneous leishmaniasis.

Cutaneous leishmaniasis being a neglected tropical disease (NTD) faces several challenges in chemotherapy. If infected with secondary bacterial infections, the treatment regime of cutaneous ulcers in cutaneous leishmaniasis is further complicated which usually require two or more than two chemotherapeutic agents for healing. In the current study, seven curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS) formulations (namely F1-F7) were prepared by mixing different excipients (oils, surfactants,...

pH-responsive hybrid magnetic polyelectrolyte complex based on alginate/BSA as efficient nanocarrier for curcumin encapsulation and delivery.

Curcumin-loaded hybrid magnetic nanoparticles (HMNPs) were formulated using a simple and green method. At first, surface of FeO nanoparticles was modified using alginate (ALG), and magnetic ALG/FeO nanoparticles with a size of 33 nm and a zeta potential of -25 mv were prepared. Then, a complex including bovine serum albumin (BSA) and poly((3-acrylamidopropyl)trimethylammonium chloride) (p(APTMACl)) was prepared and optimized. The behavior of the BSA/p(APTMACl) complex was evaluated as a function of pH and...

Mesenchymal stem cells-curcumin loaded chitosan nanoparticles hybrid vectors for tumor-tropic therapy.

The combination of controlled release technology and targeted drug delivery has become a promising strategy for cancer therapy. In this study, cell-nanoparticle hybrid vector was constructed using mesenchymal stem cells as the targeting cellular carrier and biotinylated chitosan polymer nanoparticles as the drug depot. Drug-loaded nanoparticles (hydrodynamic size =377.0 ± 14.6 nm and zeta potential = 9.6 ± 1.9 mV) were prepared by encapsulating hydrophobic model drug curcumin into biotinyl...

Biosynthesis of silver nanoparticles using red algae Portieria hornemannii and its antibacterial activity against fish pathogens.

In the present study, red algae Portieria hornemannii was scrutinized for the productive synthesis of silver nanoparticles. These biosynthesized nanoparticles were characterized by visible color change and ultraviolet visible spectrophotometry that indicated the formation of nanoparticles at the absorbance of 418 nm. Fourier transforms infrared spectroscopy, X-ray Diffraction analysis was further carried out to study the functional groups and crystalline nature of the substance. Scanning electron microsco...

Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus.

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. Th...

Nasopharyngeal cancer combination chemoradiation therapy based on folic acid modified, gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid nanoparticles.

Current treatment of advanced-stage nasopharyngeal carcinoma (NPC) is not satisfactory. Here, we developed a folic acid (FA) modified, gefitinib (GEF) and yttrium 90 (Y90) co-loaded, core-shell structured lipid-polymer hybrid nanoparticles (FA-GEF-Y90-LPNP). The size and zeta potential, drug release behavior, and uptake by tumor cells were investigated. The antitumor efficiency and toxicity of LPNP were evaluated in cancer cells and in tumor bearing mice. FA-GEF-Y90-LPNP with a mean size of 150 nm and zet...

Applications of FeO@AC nanoparticles for dye removal from simulated wastewater.

This study deals with the removal of cationic dyes from the simulated wastewater using FeO nanoparticles loaded activated carbon. FeO@AC nanoparticles were synthesised using co-precipitation methods. The FeO@AC nanoparticles (nps) were characterised using different techniques and data revealed that the synthesised nanoparticles were 6-16 nm in diameter. pHpzc of FeO@AC nanoparticles was 7.8. BET surface area of FeO@AC nps was found to be 129.6 m/g by single point method and 1061.9 m/g by multipoint meth...

HfN nanoparticles: an Unexplored Catalyst for the Electrocatalytic Oxygen Evolution Reaction.

Water electrolysis is one of the most promising methods to produce H2 and O2 as high potential fuels. Among the two half-reactions, Oxygen Evolution Reaction (OER) is more difficult to be optimized and still relies on expensive noble-metal based catalysts on Ru or Ir. In this paper, we prepared and tested in OER for the first-time nanoparticles of HfN and Hf2ON2. HfN, in particular, was shown to be a highly active catalyst with requiring an overpotential of only 391 mV at 10 mA/cm2 in Fe-free electrolyte an...

Understanding effect of solution chemistry on heteroaggregation of zinc oxide and copper oxide nanoparticles.

The reported presence of mixture of nanoparticles in environmental water warrants developing understanding on their aggregation and fate. This study tried to address this question and focused on understanding effects of pH (3,7 and 10), background electrolyte concentration (1 mM and 10 mM as NaCl) and nanoparticle (NP) concentration (1 and 10 mg/L) on stability of suspension containing mixture of two commonly-found metal oxide-based NP (i.e., ZnO and CuO NPs) in a 6-h study (output variables: aggregat...

Nifedipine-loaded polymeric nanoparticles: Preparation and in vitro characterization.

The purpose of the current study was to prepare nifedipine (NF) loaded-PLGA nanoparticles (NPs) using two different methods (nanoprecipitation method (N-2) and emulsion-solvent evaporation method (N-4)) to achieve the sustained release of NF and to reduce its side effects, and also to investigate the in vitro characteristics of NPs (surface morphology, particle size and size distribution, encapsulation efficiency and in vitro release characteristics). SEM images of nanoparticles revealed their approximate s...

Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin.

The aim of this work was to optimize the preparative process of quercetin loaded casein nanoparticles as well as to evaluate the pharmacokinetics of this flavonoid when administered orally in Wistar rats. Nanoparticles were obtained by coacervation after the incubation of casein, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and quercetin in an aqueous environment. Then, nanoparticles were purified and dried. The resulting nanoparticles displayed a size of 200 nm with a negative zeta potential and a payload of...

Long-chain polyphosphate is a potential agent for inducing mucosal healing of the colon in ulcerative colitis.

The goal of ulcerative colitis (UC) treatment has recently been shown to be "mucosal healing", as no drug directly induces mucosal healing. Probiotics possess sufficient safety, but their efficacy in the treatment of UC remains controversial because of the influence of the intestinal conditions. It is believed that the identification of bioactive molecules produced by probiotics and their application will help to solve this issue. We therefore identified a probiotic-derived long-chain polyphosphate as a mol...

CD30 Aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells.

Nanoparticles (NPs) conjugated with aptamers have been extensively in recent years, which can efficiently target cancer cells that improve the therapeutic effect. Aptamers (Apt) are small oligonucleotide molecule ligands have specific high-affinity. In this work, we developed a PEG-PLGA nanoparticles (NPs) encapsulated with doxorubicin. The NPs were modified with C2NP , a ssDNA aptamer specifically binding to CD30 protein which was over expressed in anaplastic large cell lymphoma (ALCL) cells. PEG-PLGA nano...


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