PubMed Journals Articles About "DATS Cumulative Irritation Sensitization" RSS

07:14 EST 29th January 2020 | BioPortfolio

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Showing "dATS Cumulative Irritation Sensitization" PubMed Articles 1–25 of 1,100+

The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia/reperfusion injury.

Diallyl trisulfide (DATS) is distinguished as the most potent polysulfide isolated from garlic. The aim of our study was to investigate effects of oral administration of DATS on healthy and diabetic rats, with special attention on heart function. Rats were randomly divided into four groups: CTRL (healthy rats), DATS (healthy rats treated with DATS), DM (diabetic rats), DM + DATS (diabetic rats treated with DATS). DATS (40 mg/kg of body weight) was administered every other day for 3 weeks, at the end o...

In vitro and in vivo evaluation of core-shell mesoporous silica as a promising water-insoluble drug delivery system: Improving the dissolution rate and bioavailability of celecoxib with needle-like crystallinity.

The objective of our study was to prepare mesoporous silica nanoparticles with a core-shell structure (CSMSNs) and improve the dissolution and bioavailability of Celecoxib (Cxb), a water-insoluble drug, by changing its needlelike crystal form. CSMSNs are prepared by a core-shell segmentation self-assembly method. The S and V of CSMSNs were 890.65 m/g and 1.23 cm/g, respectively. Cxb was incorporated into CSMSNs by the solvent evaporation method. The gastrointestinal irritancy of the CSMSNs was evaluated by ...

Long-term exposure to daily ethanol injections in DBA/2J and Swiss mice: Lessons for the interpretation of ethanol sensitization.

Most mice ethanol sensitization studies focused on neurobiology at the expense of its behavioral characterization. Furthermore, relatively short ethanol exposures (10 to 20 injections) were used in these studies. The first aim of the present study is to better characterize the development and expression of ethanol sensitization after an extended exposure of 45 daily injections. In some previous studies, mice were classified as "respondent" and "resistant" to ethanol sensitization. The second aim of the pres...

Could Bet v 1 affect sensitization molecular pattern in children?

Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults.

Association between sensitization and allergic diseases in 7-years-old Korean children.

Sensitization is associated with the exacerbation, severity, and prognosis of allergic diseases in children OBJECTIVE: We characterized the association between sensitization patterns and allergic diseases.

Meningitis without meningeal irritation signs: What are the alerting clinical markers?

To identify parameters that may increase the likelihood of meningitis, and suggest a need for lumbar puncture (LP), in patients without meningeal irritation signs (MIS).

Identifying Potential Co-Sensitization and Cross-Reactivity Patterns Based on Component-Resolved Diagnosis.

Component-Resolved diagnosis (CRD) can help to establish immunoglobulin E (IgE) sensitization profiles and potential risks and determines whether specific IgE is the result of primary sensitization or cross-reactivity, especially for those who are polysensitized.

Bladder-bowel interactions: Do we understand pelvic organ cross-sensitization? International Consultation on Incontinence Research Society (ICI-RS) 2018.

Mounting evidence from experimental animal and human studies suggests that cross-sensitization exists between different organs. Lower urinary tract (LUT) and bowel dysfunction commonly overlap, and the role of cross-sensitization between pelvic visceral organs is uncertain.

Patterns of sensitization to aeroallergens and their effect on airway hyper-responsiveness in Busan, Korea.

Allergen sensitization and its influence on allergic disease can vary depending on ethnicity and geography.

New insights into the sensitization to non-related nsLTPs from pollen and food: new role of the allergen Ole e 7.

Ole e 7 is a non-specific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross-reactivity which explains this observed co-sensitization. Therefore, the purpose of this study was to explore the relationship between Ole e 7 and Pru p 3.

Co-sensitization and cross-reactivity of Blomia tropicalis with two Dermatophagoides species in Guangzhou, China.

Contradictory results have been reported previously in the analyses of cross-reactivity among Blomia tropicalis (Blo t), Dermatophagoides pteronyssinus (Der p), and Dermatophagoides farinae (Der f). This study aims to investigate the characteristics of co-sensitization and the IgE cross-reactivity among them and attempts to identify whether patients are sensitized to Blo t due to cross-reaction or true sensitization.

Is atopic sensitization associated with indicators of early vascular ageing in adolescents?

Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization and allergic diseases were associated with altered vascular biomarkers in Norwegian adolescents.

The extent of pain is associated with signs of central sensitization in patients with hip osteoarthritis.

Central sensitization may be present in some patients with hip osteoarthritis (OA), often reflected as widespread pain. We examine the association between pain extent with signs of central sensitization and other clinical and psychological features in patients with hip OA.

Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway.

There is growing evidence that environmental peanut exposure through non-oral routes, including the skin and respiratory tract, can result in peanut sensitization. Environmental adjuvants in indoor dust can promote sensitization to inhaled antigens, but whether they contribute to peanut allergy development is unclear.

Efficient Er:I → I radiative transition regulated by optimizing the sensitization mechanism.

A series of fluorophosphates glass codoped with active Er ions and sensitizing ions of different systems were prepared to systematically study their sensitization effect in order to obtain efficient MIR luminescence. Differential scanning calorimetry curve indicates the favorable thermal stability of the glass host. A comprehensive analysis of the sensitization mechanism is given based on the synthesis considering the position and intensity of fluorescence emissions together with the lifetime of Er:I active...

Ocular surface and tear film changes in workers exposed to organic solvents used in the dry-cleaning industry.

Workers in the dry-cleaning industry are exposed to organic solvents that may cause eye irritation and tear film changes. Objective To quantify changes in the ocular surface and tear film in dry cleaners exposed to organic solvents and associate these changes with ocular irritation as reported in a symptom questionnaire for dry eye diagnosis. Methods This was a case and control study in which the characteristics and eye-irritation symptoms were compared between two groups of 62 participants that were either...

Role of orexin-1 and -2 receptors within the nucleus accumbens in the acquisition of sensitization to morphine in rats.

It has been reported that orexins A and B are involved in the mediation of drug reward. In addition, the nucleus accumbens (NAc) has an important role in the development of morphine-conditioned place preference (CPP) and morphine sensitization. In the present study, we aimed to evaluate the role of orexin receptors within the NAc in morphine sensitization using CPP paradigm. Adult male Wistar rats were used and were bilaterally implanted by two cannulae in the NAc. The animals received intra-accumbal admini...

Individual differences in the perception of orthonasal irritation induced by food.

Oral responsiveness to the burning/spicy sensation affects food behaviors and diet; therefore, it is reasonable to hypothesize that the variation in nasal responsiveness to irritant foods may play a role in modulating food behaviors. This study explored the variation among individuals in orthonasal irritation induced by smelling food ingredients containing irritant compounds: mustard oil (2.0, 10.0, and 100.0% v/v mustard oil in corn oil; irritant compound: allyl isothiocyanate); vinegar (3.5, 42.3, and 98....

Pharmacological NOS-1 Inhibition Within the Hippocampus Prevented Expression of Cocaine Sensitization: Correlation with Reduced Synaptic Transmission.

Behavioral sensitization to psychostimulants hyperlocomotor effect is a useful model of addiction and craving. Particularly, cocaine sensitization in rats enhanced synaptic plasticity within the hippocampus, an important brain region for the associative learning processes underlying drug addiction. Nitric oxide (NO) is a neurotransmitter involved in both, hippocampal synaptic plasticity and cocaine sensitization. It has been previously demonstrated a key role of NOS-1/NO/sGC/cGMP signaling pathway in the de...

Breastfeeding promotes egg white sensitization in early infancy.

A recent systematic review indicates that food sensitization in early childhood is a risk factor, not only for food allergies, but also for developing an allergic march which can lead to airway allergic diseases . Over the past few decades, many groups have studied risk factors for allergic diseases, including sensitization. These risks include eczema, gut microbiome, timing of introduction of solid food, Vitamin D, etc.

Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats.

Enhancement of oral absorption of food allergens by non-steroidal anti-inflammatory drugs (NSAIDs), especially aspirin, is considered an exacerbating factor in the development of food allergies. In this study, we examined the effect of aspirin on oral sensitization to and absorption of the egg-white allergen ovalbumin (OVA) in rats. The absorption of OVA was evaluated by measuring the plasma concentration of OVA after oral administration by gavage. To evaluate oral sensitization to OVA, plasma levels of imm...

Rare-Earth and Antimony-Oxo Clusters Simultaneously Connecting Antimonotungstates Comprising Divacant and Tetravacant Keggin Fragments.

Four novel rare-earth (RE) and Sb-oxo clusters simultaneously bridging antimonotungstates (ATs) [HN(CH)]NaH{[RE(HO)SbO](SbWO)(SbWO)}·24HO [RE = Dy (), Er (), Y (), Ho ()] were triumphantly isolated by using Na[B-α-SbWO]·19.5HO, dimethylamine hydrochloride, SbCl, and RE(NO)·6HO in acidic aqueous solution. Their tetrameric polyoxoanions are all established by two [SbWO] and two [B-α-SbWO] segments encapsulating a RE-Sb heterometal [RE(HO)SbO] cluster. Under the O→W LMCT excitation at 268 nm of AT segme...

Role of timing of exposure to pets and dampness or mold on asthma and sensitization in adolescence.

Pet and dampness or mold exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence.

Passive exposure of non-smokers to E-Cigarette aerosols: Sensory irritation, timing and association with volatile organic compounds.

The current study examined symptoms of irritation reported by non-smokers passively exposed to e-cigarette aerosols and their timing and association with the concentrations of volatile organic compounds (VOCs) produced.

Cumulative Metrics of Tendon Load and Damage Vary Discordantly with Running Speed.

Cumulative load has become a popular metric in running biomechanics research to account for potential spatiotemporal changes associated with different locomotion strategies. This study investigated how incorporating mechanical fatigue principles into Achilles tendon cumulative load measurements affected their relationship with running speed.

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