PubMed Journals Articles About "Emergence Chikungunya Republic Congo 2019 Associated With Possible" RSS

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Showing "emergence chikungunya Republic Congo 2019 associated with possible" PubMed Articles 1–25 of 3,700+

Re-emergence of chikungunya in the Republic of the Congo in 2019 associated with a possible vector-host switch.

In January 2019, an outbreak of Chikungunya virus fever was reported in a rural region near Pointe-Noire, Republic of the Congo. Molecular and phylogenetic analysis of this new CHIKV strain demonstrated the presence of the A226 V substitution and a surprisingly close relation with Aedes aegypti-associated Central Africa chikungunya strains. These results, combined with the preponderance of Aedes albopictus in the outbreak area, suggest a recent vector-host switch facilitated by the emergence and spread of...

Analysis of a vector-bias malaria transmission model with application to Mexico, Sudan and Democratic Republic of the Congo.

Malaria is a deadly disease transmitted to human through the bite of infected female mosquitoes. The aim of this paper is to study the different vector-bias values between low and high transmission areas with the examples of Mexico (low) and Sudan, Democratic Republic of the Congo (Congo, DR) (high) during malaria transmission. We develop a malaria transmission model with vector-bias and investigate the basic reproduction number, the existence of equilibria and the corresponding globally asymptotically stab...

Factors associated with uncontrolled asthma in adult asthmatics in Kinshasa, Democratic Republic of Congo.

The ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).

The impact of an insecticide treated bednet campaign on all-cause child mortality: A geospatial impact evaluation from the Democratic Republic of Congo.

To test the impact of a nationwide Long-Lasting Insecticidal Nets [LLINs] distribution program in the Democratic Republic of Congo [DRC] on all-cause under-five child mortality exploiting subnational variation in malaria endemicity and the timing in the scale-up of the program across provinces.

Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance.

This study gives an overview of a decade (2007-2017) of hospital-based Salmonella Typhi bloodstream infection (BSI) surveillance in the Democratic Republic of the Congo (DRC), at 4 main sampling sites.

Ankle Brachial Index (ABI) predicts 2-year mortality risk among older adults in the Republic of Congo: The EPIDEMCA-FU study.

Peripheral artery disease (PAD) is known to be associated with mortality in high income countries but no data regarding Sub-Saharan Africa (SSA) populations are documented. This study aimed at assessing the prognostic value of the Ankle Brachial Index (ABI) among older adults in the Republic of Congo.

2017 Outbreak of Ebola Virus Disease in Northern Democratic Republic of Congo.

In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak.

Differences in family planning outcomes between military and general populations in Kinshasa, Democratic Republic of the Congo: a cross-sectional analysis.

To examine family planning outcomes among women living in military camps in Kinshasa, Democratic Republic of the Congo, and compare these outcomes with a representative sample of non-military women in Kinshasa.

The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018-2019.

The international response to the evolving Ebola epidemic in eastern Democratic Republic of Congo (DRC) has had interim successes while facing ongoing difficulties. The outbreak has occurred in an area of intractable conflict among multiple armed groups at a time of contentious national elections. Despite porous international borders and considerable population movement, however, transmission has been confined to North Kivu and Ituri provinces. Factors potentially contributing to this containment include co...

"Even if she's really sick at home, she will pretend that everything is fine.": Delays in seeking care and treatment for advanced HIV disease in Kinshasa, Democratic Republic of Congo.

HIV prevalence in the Democratic Republic of Congo (DRC) is estimated to be 1.2%, and access to HIV testing and treatment remains low across the country. Despite advances in treatment, HIV continues to be one of the main reasons for hospitalisation and death in low- and middle-income countries, including DRC, but the reasons why people delay seeking health-care when they are extremely sick remain little understood. People in Kinshasa, DRC, continue to present to health-care facilities in an advanced stage o...

Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study.

Multidrug-resistant tuberculosis (MDR-TB) jeopardizes global TB control. The prevalence and predictors of Rifampicin-resistant (RR) TB, a proxy for MDR-TB, and the treatment outcomes with standard and shortened regimens have not been assessed in post-conflict regions, such as the South Kivu province in the eastern Democratic Republic of the Congo (DRC). We aimed to fill this knowledge gap and to inform the DRC National TB Program.

Distribution of the cytochrome P450 2C8*2 allele in Brazzaville, Republic of Congo.

Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy and safety. Individuals carrying CYP2C8*2 c.805A > T (CYP2C8*2; rs11572103) allele have impaired amodiaquine (AQ) metabolism, increased risk of amodiaquine - related adverse events and may promote selection of drug - resistant parasite strains. This study investigated the distribution of CYP2C8*2 alle...

A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus.

Chikungunya is a mosquito-borne virus transmitted by mosquitoes from the Aedes genus. The virus, endemic to parts of Asia and Africa, has recently undergone an emergence in other parts of the world where it was previously not found including Indian Ocean Islands, Europe, the Western Pacific and the Americas. There is no vaccine against chikungunya virus, which means that prevention and mitigation rely on personal protective measures and community level interventions including vector control.

Genetic landscape and macro-evolution of co-circulating Coxsackieviruses A and Vaccine-derived Polioviruses in the Democratic Republic of Congo, 2008-2013.

Enteroviruses (EVs) are among the most common viruses infecting humans worldwide but only a few Non-Polio Enterovirus (NPEV) isolates have been characterized in the Democratic Republic of Congo (DR Congo). Moreover, circulating vaccine-derived polioviruses (PVs) [cVDPVs] isolated during multiple outbreaks in DR Congo from 2004 to 2018 have been characterized so far only by the sequences of their VP1 capsid coding gene. This study was carried to i) investigate the circulation and genetic diversity of NPEV an...

Whole-gene analysis of inter-genogroup reassortant rotaviruses from the Dominican Republic: Emergence of equine-like G3 strains and evidence of their reassortment with locally-circulating strains.

Inter-genogroup reassortant group A rotavirus (RVA) strains possessing a G3 VP7 gene of putative equine origin (EQL-G3) have been detected in humans since 2013. Here we report detection of EQL-G3P[8] RVA strains from the Dominican Republic collected in 2014-16. Whole-gene analysis of RVA in stool specimens revealed 16 EQL-G3P[8] strains, 3 of which appear to have acquired an N1 NSP1 gene from locally-circulating G9P[8] strains and a novel G2P[8] reassortant possessing 7 EQL-G3-associated genes and 3 genes f...

Correction: Individual- and community-level determinants of child immunization in the Democratic Republic of Congo: A multilevel analysis.

[This corrects the article DOI: 10.1371/journal.pone.0202742.].

Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo.

Few phenomena have had as profound or long-lasting consequences in human history as the emergence of large-scale centralized states in the place of smaller scale and more local societies. This study examines a fundamental, and yet unexplored, consequence of state formation: its genetic legacy. We studied the genetic impact of state centralization during the formation of the eminent precolonial Kuba Kingdom of the Democratic Republic of the Congo (DRC) in the 17th century. We analyzed genome-wide data from o...

Chikungunya virus infection prevalence in Africa: a contemporaneous systematic review and meta-analysis.

The (re)emergence of chikungunya virus (CHIKV) in Africa requires better knowledge on the epidemiology of CHIKV infection in the continent for efficient public health strategies. We aimed to describe the epidemiology of CHIKV infection in Africa, a neglected tropical disease (NTD).

Update on Vaccine-Derived Poliovirus Outbreaks - Democratic Republic of the Congo and Horn of Africa, 2017-2018.

Widespread use of live attenuated (Sabin) oral poliovirus vaccine (OPV) has resulted in marked progress toward global poliomyelitis eradication (1). However, in underimmunized populations, extensive person-to-person transmission of Sabin poliovirus can result in genetic reversion to neurovirulence and paralytic vaccine-derived poliovirus (VDPV) disease (1). This report updates (as of February 26, 2019) previous reports on circulating VDPV type 2 (cVDPV2) outbreaks during 2017-2018 in the Democratic Republic...

Hepatitis B infection among pregnant and post-partum women living with HIV and on antiretroviral therapy in Kinshasa, DR Congo: A cross-sectional study.

Hepatitis B virus (HBV) co-infection in HIV-infected individuals increases the risk of hepatic complications and mortality. Further, the risk of perinatal HBV transmission increases among HBV/HIV co-infected pregnant women. Although HBV is endemic in the Democratic Republic of Congo, there is little data on HBV/HIV co-infection. We aimed to assess the burden and risk factors of HBV surface antigen (HBsAg) positivity among HIV-infected pregnant and post-partum women.

Increasing number of imported Plasmodium ovale wallikeri malaria in Shandong Province, China, 2015-2017.

Since 2012, no indigenous malaria case have been reported in Shandong Province, China, whereas the number of imported cases and the genetic diversity of Plasmodium spp. have increased. Beginning in 2015, the number of Plasmodium ovale cases were increased and the P. ovale wallikeri malaria case began to arise. From 2015 to 2017, a total of 677 imported malaria cases were detected and 76 P. ovalespp. isolates were identified, of which 48 were P. ovale curtisi and 28 P. ovale wallikeri. The number of P. ovale...

Do patients from the Democratic Republic of Congo with schizophrenia have facial emotion recognition deficits?

Patients with schizophrenia can have difficulty recognizing emotion, and the impact of this difficulty on social functioning has been widely reported. However, earlier studies did not thoroughly explore how this deficit may vary according to emotion intensity, or how it may differ among individuals and across cultures. In the present study, our aim was to identify possible deficits in facial emotion recognition across a wide range of emotions of different intensities among patients with schizophrenia from t...

Emergence and re-emergence of mosquito-borne arboviruses.

Arthropod-borne viruses (arboviruses) are ecologically distinct from many other pathogens because of the involvement of arthropod vectors and animal reservoirs. Several mosquito-borne arboviruses have emerged in various geographic regions during the past few decades. Since the beginning of the 21st century, the emergence of two mosquito-borne arboviruses, chikungunya and Zika, has taken place globally. Millions of infections have not only changed the epidemiology of previously obscure viruses, but also put ...

Antiviral activity of ethanolic extract of Nilavembu Kudineer against dengue and chikungunya virus through in vitro evaluation.

Currently, no vaccines or modern drugs are available for dengue and chikungunya and only symptomatic relief is provided to the patients. Siddha medicine, a traditional form of indigenous medical system uses specific polyherbal formulations for the treatment of such infections with considerable success. One such polyherbal formulation for the treatment of chikungunya and dengue is Nilavembu kudineer (NVK). The mechanistic details of this drug as an antiviral for chikungunya virus (CHIKV) and dengue virus (DE...

"So that's why I'm scared of these methods": Locating contraceptive side effects in embodied life circumstances in Burundi and eastern Democratic Republic of the Congo.

Contraceptive side effects (SE) are often portrayed as either unproblematic trade-offs for pregnancy prevention or misconceptions and fears that negatively affect individuals' contraceptive decisions. Little attention is given, however, to wider, socially-rooted meanings and rationales for these feared and experienced SE. Through inductive analysis of in-depth interviews conducted with women and men from rural Burundi and South Kivu province, Democratic Republic of the Congo between 2013 and 2016, we locate...

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