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PubMed Journals Articles About "Molecular Mass Iron Complexes Blood Plasma Iron Deficient" RSS

23:53 EST 19th November 2019 | BioPortfolio

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Showing "molecular mass iron complexes blood plasma iron deficient" PubMed Articles 1–25 of 35,000+

Low-molecular-mass iron complexes in blood plasma of iron-deficient pigs do not originate directly from nutrient iron.

Nutrient iron entering the blood binds transferrin (TFN)d, which delivers iron to cells in the body. In healthy individuals, ∼30% of TFN is iron-bound while the remainder is unbound (apo-TFN). TFN saturates the plasma of individuals with iron-overload diseases such as hereditary hemochromatosis, prompting release of a poorly-defined low-molecular-mass (LMM) iron species called non-transferrin-bound iron (NTBI). An experiment was devised to directly detect NTBI in plasma of iron-deficient pigs and to asses...


High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial.

Frequent blood donation often leads to iron deficiency and even anemia but appropriate strategies for detection and prevention are currently not mandatory. At the Medical University of Graz, we conducted a single-center prospective clinical trial to compare oral and IV iron supplementation in iron deficient blood donors including Austrian regular whole blood and platelet apheresis donors. We aimed to determine the difference of transferrin saturation between the treatment groups 8-12 weeks iron administrati...

Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice.

Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen. Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase. Links between iron metabolism and other metals being suggested, ...


The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood.

Iron deficiency is the most common micronutrient deficiency in the world and disproportionately affects pregnant women and young children. Iron deficiency has negative effects on pregnancy outcomes in women and on immune function and neurodevelopment in children. Iron supplementation programs have been successful in reducing this health burden. However, iron supplementation of iron-sufficient individuals is likely not necessary and may carry health risks for iron-sufficient and potentially some iron-deficie...

Liver-Specific but Not Retina-Specific Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration.

The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels. Hepc accomplishes this by triggering degradation of the only known cellular iron exporter ferroportin in the gut, macrophages, and the liver. We previously demonstrated that systemic HepcKO mice, which have high serum iron, develop retinal iron overload and degeneration. However, it was unclear whether this is caused by high blood iron levels or alternatively, due to retinal iron influx that would normally be regulated by r...

FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors.

There is increasing evidence that frequent blood donation depletes the iron stores of some blood donors. The FinDonor 10 000 study was set up to study iron status and factors affecting iron stores in Finnish blood donors. In Finland, iron supplementation for at-risk groups has been in place since the 1980s.

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice.

Iron supplementation therapy is used for iron-deficiency anemia but has been associated with macular degeneration in a 43-year-old patient. Iron entry into the neurosensory retina (NSR) can be toxic. It is important to determine conditions under which serum iron might cross the blood retinal barrier (BRB) into the NSR. Herein, an established mouse model of systemic iron overload using high-dose intraperitoneal iron dextran (IP FeDex) was studied. In addition, because the NSR expresses the iron regulatory ho...

Characterizing the iron loading pattern of ferritin using high-mass MALDI-MS.

Ferritin is an iron storage protein assembly, usually formed by a 24-subunit protein shell and an iron core. The ferritin shell has been well studied using different structural biology tools such as X-ray diffraction and cryo-electron microscopy, whereas the iron status of ferritin is less studied and no well-established method exists for characterizing the distribution of the iron loading of ferritin. Recent advances of mass spectrometry (MS) have expanded the observable m/z range, making the measurement o...

Compound repair effect of carbon dots and Fe on iron deficiency in Cucumis melon L.

Iron-deficiency is one of the most widespread micronutrient deficiency faced by plants, and proper iron supplementation is essential for the growth of crops and for people to obtain iron from food. In order to explore new methods of iron supplementation, we studied the repair effect of CDs on iron-deficient (Cucumis melo L.) muskmelon. Iron-deficient muskmelons were treated with different concentrations of Fe, CDs and their complexes. The results showed that CDs significantly increased the iron transport ra...

Pagophagia in men with iron-deficiency anemia.

Few case series of pagophagia and iron deficiency include men. We performed a retrospective study of non-Hispanic white men with iron-deficiency anemia whose anemia and pagophagia, thrombocytosis, and thrombocytopenia (if present) resolved after iron replacement. Iron-deficiency anemia was defined as transferrin saturation (TS)

Catalytic C-H Borylation Using Iron Complexes Bearing 4,5,6,7-Tetrahydroisoindol-2-ide-Based PNP-Type Pincer Ligand.

We have newly designed the iron-catalyzed C-H borylation using iron complexes bearing a 4,5,6,7-tetrahydroisoindol-2-ide-based PNP pincer ligand, based on results of stoichiometric reactions of the iron complexes. As a result, we can apply a variety of arenes, not only benzene derivatives but also 5-membered heteroarenes such as pyrrole derivatives, to the C-H borylation. We have also found the first successful example of the iron-catalyzed sp3 C-H borylation in the reaction of 4-methylanisole.

Screening umbilical cord blood for congenital Iron deficiency.

Small for gestational age infants (SGA), infants of diabetic mothers (IDM), and very low birth weight infants (VLBW) are at risk for congenital iron deficiency. We evaluated the iron status of SGA, IDM, and VLBW neonates at birth and sought mechanistic explanations in those with iron deficiency.

Diagnostic Significance of Biomarkers of Iron Deficiency for Anemia in Clinical Practice.

Iron deficiency anemia (IDA) is a common medical condition, yet there is still some diagnostic uncertainty in this respect. The aim of this study was to compare the clinical significance of biomarkers of iron deficiency (ID) in diagnosing IDA and iron-deficient erythropoiesis in anemic patients.

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.

Iron is essential for many types of biological processes. However, excessive iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron-dependent regulated form of necrosis, was recently discovered, iron and iron-catalysed oxidative stress have attracted much interest because of their sophisticated mechanism of cellular signalling leading to cell death and associated with various diseases.

Urinary iron excretion for evaluating iron chelation efficacy in children with thalassemia major.

In patients with thalassemia major, examination routinely used for the evaluation of iron load in Indonesia is serum ferritin, but it is strongly influenced by other factors such as infections, inflammation and vitamin C levels. Evaluation of urinary iron excretion is an important and easy method to indicate iron chelation efficacy.

Safety of Oral and Intravenous Iron.

As the adverse effects of iron deficiency are better recognized, the use of oral and intravenous iron has increased dramatically. Oral iron is often poorly tolerated, with up to 70% or more of patients noting gastrointestinal issues; this may affect adherence to therapy. In addition, many patients will not respond to oral iron due to their underlying illness. Intravenous iron is being used more frequently to replete iron stores. True anaphylaxis is very rare, but complement-mediated infusion reactions may b...

Effect of Iron Deficiency on a Murine Model of Smoke-Induced Emphysema.

Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Smoking susceptibility is important for the onset and development of COPD. We previously reported an association between serum iron levels and pulmonary function in male smokers. However, the mechanism governing smoking susceptibility in relation to iron deficiency is unclear; this study aimed to elucidate this mechanism. C57BL/6 male mice were fed an iron-deficient or normal diet, and then exposed to cigarette smoke. Bronchoal...

Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei.

Similar to higher eukaryotes, the protist parasite T. brucei harbours several iron-containing proteins that regulate DNA and protein processing, oxidative stress defence and mitochondrial respiration. The synthesis of these proteins occurs either in the cytoplasm or within the mitochondrion. For mitochondrial iron cluster protein synthesis, iron needs to be transported across the solute impermeable mitochondrial membrane. In T. brucei we previously identified 24 mitochondrial carrier proteins (TbMCPs) shari...

Does localised iron loss in venous disease lead to systemic iron deficiency: A descriptive pilot study.

Haemosiderin deposition in the legs of patients with venous leg ulcers is well established and several theories suggest this stored iron has a role in disease pathophysiology. In this novel pilot study of patients with chronic venous leg ulcers we aimed to establish the relationship between wound fluid iron levels, serum iron parameters and healing. 15 patients with venous ulcers were included in the study. Blood samples were taken for full blood count and iron studies, while simultaneously wound fluid was ...

Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization.

Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. In this study, we show that dZIP13 level is strongly regulated by iron. In addition to a mild response to iron at the mRNA level, dZIP13 is strongly regulated at the protein level. This posttranslational regulation by iron also happens when dZIP13 is expressed in the yeast Saccharomyces cerevisiae. Iron functions to stabilize dZIP13. Domain-swapping experiments between dZIP7 (CG10449/...

A hybrid (iron-fat-water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging.

Assessment of iron content in the liver is crucial for diagnosis/treatment of iron-overload diseases. Nonetheless, T*-based methods become challenging when fat and iron are simultaneously present. This study proposes a phantom design concomitantly containing various concentrations of iron and fat suitable for devising accurate simultaneous T* and fat quantification technique.

Impact of Transferrin Saturation on All-Cause Mortality in Patients on Maintenance Hemodialysis.

Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.

Deferiprone exerts a dose dependent reduction of liver iron in adults with iron overload.

While doses of deferiprone up to 75 mg/kg/day have been demonstrated to be effective in cardiac iron removal, their efficacy in the reduction of liver iron have been equivocal. The aim of this study was to evaluate the effect of deferiprone dose on liver iron concentrations in adult iron overload patients.

The effect of donation activity dwarfs the effect of lifestyle, diet and targeted iron supplementation on blood donor iron stores.

The iron status of blood donors is a subject of concern for blood establishments. The Finnish Red Cross Blood Service addresses iron loss in blood donors by proposing systematic iron supplementation for demographic at-risk donor groups. We measured blood count, ferritin and soluble transferrin receptor (sTfR) and acquired lifestyle and health information from 2200 blood donors of the FinDonor 10000 cohort. We used modern data analysis methods to estimate iron status and factors affecting it with a special f...

Protective effects of Ulva pertusa polysaccharide and polysaccharide‑iron (III) complex on cyclophosphamide induced immunosuppression in mice.

A water-soluble polysaccharide was isolated from marine green algae Ulva pertusa and then chelated with iron to prepare the polysaccharide‑iron (III) complex. The immunomodulatory activities of sulfated polysaccharide and polysaccharide‑iron (III) complex were investigated through a mice immune-deficiency model. Cyclophosphamide (Cy) was utilized to establish mice immunodeficiency model. Both polysaccharide and polysaccharide‑iron (III) complex were proved to promote the proliferation of lymphocyte an...


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