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11:02 EST 18th December 2018 | BioPortfolio

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Showing "more trials calcium supplements really needed response Bolland" PubMed Articles 1–25 of 22,000+

Safety of Calcium and Vitamin D Supplements, a Randomized Controlled Trial.

It is anticipated that an intake of vitamin D found acceptable by Endocrine Society Guidelines (10,000 IU/day) with co-administered calcium supplements may result in frequent hypercalciuria and hypercalcemia. This combination may be associated with kidney stones. The objective of this study was to compare the episodes of hypercalciuria and hypercalcemia from calcium supplements co-administered with 10,000 IU or 600 IU vitamin D daily. This design allows a comparison of the Institute of Medicine recommendati...

Dietary calcium intake and hypertension risk: a dose-response meta-analysis of prospective cohort studies.

The association of calcium intake with risk of developing hypertension in the general population has not been established yet. We systematically searched PubMed and Scopus databases up to February 2018 to find prospective observational studies investigating the association of calcium intake with risk of developing hypertension. The reported risk estimates were pooled using a random-effects model. Eight prospective cohort studies (248,398 participants and 30,838 cases) were included. Seven studies measured d...

The evolving landscape of criteria for evaluating tumor response in the era of cancer immunotherapy: From Karnofsky to iRECIST.

The objective response is an important endpoint to evaluate clinical activity of new anticancer drugs. Standardized criteria for evaluating response are needed for comparing results of different trials and represent the basis for advances in cancer therapy. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 are the most used in clinical practice and in clinical trials; however, they are not able to capture atypical responses seen with immunotherapy drugs. We describe the evolution of response criteri...

Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization.

Bioavailability of supplements with coenzyme Q10 (CoQ) in humans seems to depend on the excipients of formulations and on physiological characteristics of the individuals. The aim of this study was to determine which factors presented in CoQ supplements affect the different response to CoQ in humans.

Increases in absolute temperature stimulate free calcium concentration elevations in the chloroplast.

Plants need to sense increases in temperature to be able to adapt their physiology and development to survive; however, the mechanisms of heat perception are currently relatively poorly understood. Here we demonstrate that in response to elevated temperature the free calcium concentration of the stroma of chloroplasts increases. This response is specific to the chloroplast, as no corresponding increase in calcium is seen in the cytosol. The chloroplast calcium response is dose-dependent above a threshold. T...

Low calcium intakes among Australian adolescents and young adults are associated with higher consumption of discretionary foods and beverages.

Calcium is an essential nutrient required for peak bone mass growth during adolescence and into young adulthood. The aim of this study was to examine the calcium intake of Australian adolescents and young adults from both food sources and supplements; and the relationship between calcium intake and intake of food groups.

Prenatal iron containing supplements provided to Chinese women with no or mild anemia had no effect on hemoglobin concentration in post-partum women or their infants at 6 and 12 months of age.

Although prenatal iron-containing supplements have been associated with lower anemia prevalence in later pregnancy, few trials have examined the effect of supplements on the anemia status of post-partum women and their infants.

Can RECIST response predict success in phase 3 trials in men with metastatic castration-resistant prostate cancer?

Intermediate endpoints are needed in early phase studies of men with metastatic castration-resistant prostate cancer (mCRPC) that can reliably predict success in phase 3 trials. Among men with measurable disease, objective response may provide information as to whether a treatment is likely to be successful.

Effect of Vitamin D Supplementation, Food Fortification, or Bolus Injection on Vitamin D Status in Children Aged 2-18 Years: A Meta-Analysis.

Meta-analyses on the effect of vitamin D intake on status in children are lacking, especially those focused on vitamin D-fortified foods. The objective of this meta-analysis was to investigate the effect of vitamin D interventions (fortified foods, supplements, bolus injections) on vitamin D status in children 2-18 y of age. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, literature searches were conducted up to December 2016. Randomized placebo-controlled v...

Calcium release-activated calcium channels and pain.

Calcium release-activated calcium (CRAC) channels are unique among ion channels that are activated in response to depletion of intracellular calcium stores and are highly permeable to Ca compared to other cations. CRAC channels mediate an important calcium signal for a wide variety of cell types and are well studied in the immune system. They have been implicated in a number of disorders such as immunodeficiency, musculosketal disorders and cancer. There is growing evidence showing that CRAC channels are ex...

SMOOTH (Self-Management of Open Online Trials in Health) analysis found improvements were needed for reporting methods of internet-based trials.

The growth of trials conducted over the internet has increased, but with little practical guidance for their conduct and it is sometimes challenging for researchers to adapt the conventions used in face-to-face trials and maintain the validity of the work.

Antioxidant vitamins in asthma.

Asthma is a condition of unknown etiology characterized by chronic airway inflammation. Cells that mediate the inflammatory response generate reactive oxygen species that, together with other respiratory tract naturally-occurring oxidant species, produce a rupture of the redox balance, generating oxidative stress. It has been proposed that oxidative stress can be reverted by supplemental or dietary intake of antioxidant vitamins such as vitamin A, C, D and E, and this way relieve, improve or protect people ...

KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency.

Retention of critical endoplasmic reticulum (ER) luminal proteins needed to carry out diverse functions (e.g., protein synthesis and folding, lipid metabolism) is mediated through a carboxy-terminal ER retention sequence (ERS) and its interaction with KDEL receptors. Here, we demonstrate that depleting ER calcium causes mass departure of ERS-containing proteins from cells by overwhelming KDEL receptors. In addition, we provide evidence that KDELR2 and KDELR3, but not KDELR1, are unfolded protein response (U...

Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort.

Voltage-gated calcium channels have been implicated in schizophrenia aetiology; however, little is known about their involvement in antipsychotic treatment response. This study investigated variants within the calcium channel subunit genes for association with antipsychotic treatment response in a first episode schizophrenia cohort. Twelve regulatory variants within seven genes were shown to be significantly associated with treatment outcome. Most notably, the CACNA1B rs2229949 CC genotype was associated wi...

Additional food supplements as a tool for biological conservation of predator-prey systems involving type III functional response: A qualitative and quantitative investigation.

Provision of additional food supplements for the purpose of biological conservation in ecosystems has of late been intensely researched by agriculturalists, biologists and mathematicians. The study of these ecosystems is usually done using the predator-prey systems. In these ecological studies it has been observed that the quality and quantity of additional food supplements provided play a crucial role in the growth of the predators and thereby influence the eventual state of the ecosystem. Also, in some of...

Revised Modified RECIST Criteria for Assessment of Response in Malignant Pleural Mesothelioma (Version 1.1).

Malignant pleural mesothelioma poses unique difficulties in tumor measurement and response assessment; however, robust and reproducible assessment of response is critically important in the conduct, interpretation, and reporting of clinical trials. The current de-facto standard for the assessment of mesothelioma tumor response, "modified RECIST" (Response Evaluation Criteria in Solid Tumors), was published in 2004 as a research paper. Practical application of the modified RECIST guidelines has suffered from...

Effect of immunostimulatory feed supplements on the development of acquired immunity in rainbow trout (Oncorhynchus mykiss).

Immunostimulatory feed supplements are an increasingly common feature of aquaculture management and their benefit has been confirmed for a wide area of products. However, these investigations have often focused on the benefit of these supplements on the innate immune system. In the current project, we investigated a mixture of two commercial feed supplements (Biotronic Top 3 and Levabon Aquagrow E) with a known protective effect against bacterial infections. The effect of the supplemented diet on antibody t...

Determinants of antidepressant response: Implications for practice and future clinical trials.

Response to antidepressants in major depressive disorder is variable and determinants are not well understood or used to design clinical trials. We aimed to understand these determinants.

A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis.

Calcium gradient, the difference between serum calcium and dialysate calcium d[Ca], is the main contributor factor influencing calcium transfer during hemodialysis. The impact, however, of bone turnover, on calcium mass transfer during hemodialysis is still uncertain.

The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials.

This systematic review aims to determine the potential effects of oral nutritional supplements (ONS) in patients receiving maintenance dialysis therapy (MDT).

Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials.

CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.

The Chloride Channel Accessory (CLCA) protein family was first characterized as regulators of calcium-activated chloride channel (CaCC) currents (ICaCC), but the mechanism has not been fully established. We hypothesized that CLCAs might regulate ICaCC by modulating intracellular calcium levels. In cells stably expressing human CLCA2 or vector, we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic deple...

The oddball effect on P3 disappears when feature relevance or feature-response mappings are unknown.

The P3b component of human event-related EEG potentials is larger with rare than frequent task-relevant stimuli. In a previous study, this oddball effect was much reduced when stimulus-response (S-R) mappings were still undefined at stimulus presentation (being later provided by response prompts). This reduction may reflect P3b's dependence on transmitted information which might be any relevant information (informational value hypothesis) or, more specifically, information about how to respond (S-R link hyp...

Nutritional interventions in elderly gastrointestinal cancer patients: the evidence from randomized controlled trials.

Literature concerning nutritional interventions in elderly patients with gastrointestinal cancer, with special reference to randomized clinical trials, has been critically reviewed. This segment of oncologic population was found to be penalized by a high prevalence of malnutrition and sarcopenia which translated in an increased rate of toxicity from chemotherapy, poor compliance with oncologic treatments, and, finally, with a poor prognosis. Attempts to reverse this condition included a potentiation of nutr...

Association among Anterior Cingulate Cortex Volume, Psychophysiological Response, and PTSD Diagnosis in a Veteran Sample.

Posttraumatic stress disorder (PTSD) is associated with fear response system dysregulation. Research has shown that the anterior cingulate cortex (ACC) may modulate the fear response and that individuals with PTSD have abnormalities in ACC structure and functioning. Our objective was to assess whether ACC volume moderates the relationship between PTSD and fear-potentiated psychophysiological response in a sample of Gulf War Veterans. 142 Veteran participants who were associated with a larger study associate...

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