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PubMed Journals Articles About "Situ Analytical Characterization Chemical Imaging Tablet Coatings Using" RSS

13:08 EDT 24th March 2019 | BioPortfolio

Situ Analytical Characterization Chemical Imaging Tablet Coatings Using PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Situ Analytical Characterization Chemical Imaging Tablet Coatings Using articles that have been published worldwide.

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Showing "situ analytical characterization chemical imaging tablet coatings using" PubMed Articles 1–25 of 23,000+

In situ analytical characterization and chemical imaging of tablet coatings using laser induced breakdown spectroscopy (LIBS).

Laser induced breakdown spectroscopy (LIBS) has emerged as an innovative tool for quantitative and qualitative elemental analysis in pharmaceutical research. Herein, the potential use of LIBS for rapid characterization of tablet coatings is illustrated, including the investigation of coating thickness, coating uniformity and localized coating contamination. The laser shot number required for penetrating the coating correlates well with coating thickness determined from traditional scanning electron microsco...


An in situ study of chemical-mechanical polishing behaviours on sapphire (0001) via simulating the chemical product-removal process by AFM-tapping mode in both liquid and air environments.

Chemical-mechanical polishing (CMP) has drawn significant attention as one of the most advanced techniques for achieving an atomic-level smooth surface. However, the mechanism of CMP is still unclear, and the in situ characterization of CMP behaviors at the nanoscale has been a challenge for decades. In this study, we, for the first time, report an in situ study of CMP behaviors on sapphire (0001) via simulating the chemical product-removal process by using atomic force microscopy (AFM) in tapping mode. Thr...

Preparation and characterization of multi-component tablets containing co-amorphous salts: combining multimodal non-linear optical imaging with established analytical methods.

Co-amorphous mixtures have rarely been formulated as oral dosage forms, even though they have been shown to stabilize amorphous drugs in the solid state and enhance the dissolution properties of poorly soluble drugs. In the present study we formulated tablets consisting of either spray dried co-amorphous ibuprofen-arginine or indomethacin-arginine, mannitol or xylitol and polyvinylpyrrolidone K30 (PVP). Experimental design was used for the selection of tablet compositions, and the effect of tablet compositi...


Cryo-analytical STEM of frozen, aqueous dispersions of nanoparticles.

In situ characterisation of nanoparticle dispersion and surface coatings is required to further our understanding of the behaviour of nanoparticles in aqueous suspension. Using cryogenic transmission electron microscopy (cryo-TEM) it is possible to analyse a nanoparticle suspension in the frozen, hydrated state; however, this analysis is often limited to imaging alone. This work demonstrates the first use of analytical scanning TEM (STEM) in the examination of nanoparticles captured in a layer of vitreous i...

Luminescence Lifetime Imaging of Chemical Sensors - a Comparison between Time-Domain and Frequency-Domain based Camera Systems.

Luminescence lifetime based imaging is still the most reliable method for generating chemical images using chemical sensor technology. However, only few commercial systems are available that enable imaging lifetimes within the relevant ns to µs range. In this technical note we compare the performance of an older time-domain (TD) based camera systems with a frequency-domain (FD) based camera system regarding their measuring characteristics and applicability for O2 and pH imaging in environmental samples and...

Real-Time Monitoring of Fluorescence in situ Hybridization (FISH) Kinetics.

We present a novel method for real-time monitoring and kinetic analysis of fluorescence in situ hybridization (FISH). We implement the method using a vertical microfluidic probe containing a microstructure designed for rapid switching between a probe solution and a non-fluorescent imaging buffer. The FISH signal is monitored in real time during the imaging buffer wash, during which signal associated with unbound probes is removed. We provide a theoretical description of the method as well as a demonstration...

Plasma deposited nano-capsules containing coatings for drug delivery applications.

Coatings consisting in gentamicin-containing nano-capsules have been synthetized by means of an aerosol-assisted atmospheric pressure plasma deposition process. The influence of different parameters affecting the process has been extensively investigated by means of a morphological and chemical characterization of the coatings. Scanning electron microscopy highlighted the presence of nano-capsules whose size and abundance depend on power input and deposition time. A detailed analysis carried out with Matrix...

Reliability of diagnosing acute ischemic cerebrovascular on magnetic resonance imaging disorders using iPads.

The use of tablet terminals has been explored in various medical settings; however, caution should be exercised when performing image diagnosis using this technology. The present study examined the characteristics of an iPad Air™ monitor and assessed radiographic image interpretations to verify the reliability of the telediagnosis of acute cerebral infarction based on magnetic resonance imaging (MRI) using a tablet terminal.

Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index.

In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at different heights. Their compression and their tablet characterization enable establishing a powder weight for compression in accordance with its bulk density. Therefore, the resulting tablet will have a height within a ...

In-Solution Microscopic Imaging of Fractal Aggregates of a Stressed Therapeutic Antibody.

Aggregates of therapeutic proteins that can contaminate drug products during manufacture is a growing concern for the pharmaceutical industry because the aggregates are potentially immunogenic. Electron microscopy is a typical, indispensable method for imaging nanometer- to micrometer-sized structures. Nevertheless, it is not ideal because it must be performed with ex situ monitoring under high-vacuum conditions, where the samples could be altered by staining and drying. Here, we introduce a scanning electr...

Development of ALD Coatings for Harsh Environment Applications.

Atomic layer deposition (ALD) is a well-known technique for the fabrication of ultrathin and highly conformal barrier coatings which have extensively been used for the protection of electronic devices in open atmospheric conditions. Here, we extend the scope for the application low temperature deposited ALD barrier coatings for the protection of devices in a variety of chemical environments. The chemical stability tests were conducted in 3.5% NaCl, sea water, HCl (pH4) and HSO (pH4) solutions for ALD AlO, H...

Protocols for the analytical characterization of therapeutic monoclonal antibodies. III - Denaturing chromatographic techniques hyphenated to mass spectrometry.

The full analytical characterization of therapeutic monoclonal antibodies (mAbs) requires a large variety of complementary information that can be obtained by chromatographic methods. A series of protocols papers has been proposed to cover the chromatographic techniques and the enzymatic and chemical sample preparation procedures generally applied for the analytical characterization of therapeutic mAbs. The present protocol paper focuses on denaturing chromatographic techniques hyphenated to mass spectromet...

New approach to electron microscopy imaging of gel nanocomposites in situ.

Characterization of Au-nanocomposites is routinely done with scattering techniques where the structure and ordering of nanoparticles can be analyzed. Imaging of Poloxamer gel-based Au-nanocomposites is usually limited to cryo-TEM imaging of cryo-microtomed thin sections of the specimen. While this approach is applicable for imaging of the individual nanoparticles and gauging their size distribution, it requires altering the state of the specimen and is prone to artifacts associated with preparation protocol...

Advances in Surface Plasmon Resonance Imaging and Microscopy and Their Biological Applications.

Surface plasmon resonance microscopy and imaging are optical methods that enable observation and quantification of interactions of nano- and microscale objects near a metal surface in a temporally and spatially resolved manner. This review describes the principles of surface plasmon resonance microscopy and imaging and discusses recent advances in these methods, in particular, in optical platforms and functional coatings. In addition, the biological applications of these methods are reviewed. These include ...

Metastable Dumbbell Probe-Based Hybridization Chain Reaction for Sensitive and Accurate Imaging of Intracellular-Specific MicroRNAs In Situ in Living Cells.

Sensitive and accurate imaging of intracellular-specific microRNAs (miRNAs) in situ in living cells is seriously challenged by the susceptibility of nucleic acid probes and the low dynamics of the hybridization reaction in cellular environments. Herein, we engineer a set of new metastable dumbbell probes (MDPs) to overcome these key limitations by concurrently boosting transfection, anti-digestibility, assembly dynamics and nanostructural uniformity. The MDPs can maintain stable up to 16 h in living cells, ...

A facile method for fabricating robust cellulose nanocrystal/SiO superhydrophobic coatings.

A large number of superhydrophobic coatings are prepared using individual particles (especially SiO) to build rough surfaces. However, those surface structures collapse very easily, resulting in poor mechanical strength of the coating. To overcome this problem, cellulose nanocrystals (CNCs) are used as a framework material to prepare a necklace-like CNC/SiO nanostructure (referred to as CNC/SiO rod) via in-situ growth of SiO as building blocks of superhydrophobic coatings. The CNC/SiO superhydrophobic coati...

Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus.

A unique combination of sensitivity, resolution, and penetration make X-ray fluorescence imaging (XFI) ideally suited to investigate trace elemental distributions in the biological context. XFI has gained widespread use as an analytical technique in the biological sciences, and in particular enables exciting new avenues of research in the field of neuroscience. In this study, elemental mapping by XFI was applied to characterise the elemental content within neuronal cell layers of hippocampal sub-regions of ...

Physical, morphological, antimicrobial and release properties of novel MgO-bacterial cellulose nanohybrids prepared by in-situ and ex-situ methods.

MgO-bacterial cellulose (BC) nanohybrids were fabricated by in-situ synthesis of nanoparticles (NPs) within BC network via two methods (the sonochemical and wet chemical). The ex-situ synthesized nanohybrid was prepared by immersing BC pellicles in the commercial MgO dispersion. The occurrence of new interactions between MgO-NPs and nanofibers was approved by Fourier transform infrared spectroscopy (FT-IR) spectra. X-ray diffraction (XRD) results indicated that the crystallinity index of nanofibers decrease...

Molecular evidence of a toxic effect on a biofilm and its matrix.

Shewanella oneidensis MR-1 wild-type and a hyper-adhesive mutant CP2-1-S1 are used as model organisms and Cr(vi) is selected as a toxic chemical to study biofilm and toxic chemical interactions. Biofilms are cultured in a microfluidic device for in situ time-of-flight secondary ion mass spectrometry imaging. This approach is viable for studying biofilms' responses to antimicrobial resistance.

Liposome protein corona characterization as a new approach in nanomedicine.

This trends article describes the analytical approaches for the in-depth characterization of the protein corona on liposome nanoparticles. In particular, examples since 2014 are summarized according to the analytical approach. Traditional protein corona characterizations from in vitro static experiments are provided along with the newly introduced experimental setups for characterization of the protein corona by in vitro dynamic and in vivo studies. Additionally, a special attention is also devoted to the n...

In situ and ex situ NMR for battery research.

A rechargeable battery stores readily convertible chemical energy to operate a variety of devices such as mobile phones, laptop computers, electric automobiles, etc. A battery generally consists of four components: a cathode, an anode, a separator and electrolytes. The properties of these components jointly determine the safety, the lifetime, and the electrochemical performance. They also include, but are not limited to, the power density and the charge as well as the recharge time/rate associated with a ba...

Simultaneous nanostructure and chemical imaging of intact whole nematodes.

Biological X-ray fluorescence microscopy (XFM) is an important tool for determining quantitative distributions of bioinorganics and essential trace elements. Here we present a new analysis approach for rapid nanoscale ptychographic imaging and simultaneous chemical mapping of large radiation sensitive specimens without image degradation associated with probe evolution.

Imaging and Analytics on the Helium Ion Microscope.

The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron-based imaging can be performed at resolutions down to 0.5 nm with high contrast, high depth of field, and directly on insulating samples. Analytical methods include second...

Mussel-inspired dopamine-Cu coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis.

Nitric oxide (NO) is a highly potent, yet short-lived bioactive molecule with a broad spectrum of physiological functions. Continuous and controllable in situ generation of NO from vascular stent surface can effectively prevent restenosis and thrombosis after its implantation. In this study, inspired by the adhesion and protein cross-linking in the mussel byssus, through immersing the stents into an aqueous solution with dopamine (DA) and copper ions (Cu), we developed a one-step metal-catecholamine assembl...

Tip-enhanced thermal expansion force for nanoscale chemical imaging and spectroscopy in photo-induced force microscopy.

We investigate the tip-enhanced thermal expansion force for nanoscale chemical imaging and spectroscopy in the tip-sample junction. It is found, both theoretically and experimentally, that the tip-enhanced absorption of the near-field at the tip followed by sample expansion shows characteristic behaviors with respect to the sample thickness and the incident laser pulse width. The van der Waals interaction plays a major role in exerting a force on the tip from the thermally expanded sample. The force behavio...


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