Advertisement

Topics

The Effect of Amputation on Spatial Visual Representation in Peripersonal Space

2014-08-27 03:39:11 | BioPortfolio

Summary

In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space. We hypothesize that changes in the motor and somatosensory hand-related cortices following amputation might lead to changes in parietal hand-related areas. The consequence of these parietal changes should be reflected behaviorally in reduced perception/attention/responses to hand-related objects in the space ipsilateral to the amputation. We further hypothesize that the use of prosthetics may provide the necessary visual feedback to maintain an intact hand representation and therefore lead to lesser cortical reorganization in both visual and somatosensory cortical areas.

Description

In a recent fMRI study (Makin TR. et al., J. Neurosci. 2007), we found extended cortical representation for a visual stimulus provided that it is presented close to the hand. It is therefore interesting to ask whether changes in the brain following limb amputation might induce changes in the amputees' perception of the body and consequently it's surrounding. In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space. We hypothesize that changes in the motor and somatosensory hand-related cortices following amputation might lead to changes in parietal hand-related areas. Consequently, we expect to find reduced perception/attention/responses to hand-related objects in the space ipsilateral to the amputation.

In this experiment we plan to employ a paradigm which is inspired by the affordance effect, originally introduced by Tucker and Elice (1998): we will present subjects with brief images of either manipulable or non manipulable objects in either the left or right visual field. The subjects will be required to determine whether the object contains a metal or not, by moving either their left or their right shoulder. We predict that while the control group of normal subjects would show a congruency effect (that is superior performance (faster and more accurate responses) when the responding shoulder is congruent with the position of the objects, the amputees will show spatial biases towards the non-amputated side. This effect should be more prominent for the manipulable objects.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Upper Limb Amputees

Location

Neurobiology Dep., Life Sciences Institute, Hebrew Uni.
Jerusalem
Israel
91904

Status

Not yet recruiting

Source

Hadassah Medical Organization

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:39:11-0400

Clinical Trials [907 Associated Clinical Trials listed on BioPortfolio]

Bilateral Upper Limb Amputation Observatory

In France, there is currently no data to directly estimate the number of bilateral upper limb amputations, their characteristics and therapeutic care. By extrapolation from the Regional I...

Pilot Project to Evaluate the Revolutionizing Prosthetics Modular Prosthetic Limb System for Upper Extremity Amputees

The purpose of this study is to optimize the Defense Advanced Research Projects Agency's (DARPA) advanced upper limb prosthesis, the Modular Prosthetic Limb (MPL), by evaluating the perfor...

Study of Compensatory Motion While Using an Upper Limb Prosthesis

Current improvements of the design of the upper limb prosthesis include advanced technology in control systems and electronic circuitry that mimic human motion and improve function of the ...

Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees

To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically rel...

Comparing New Prothesis PROPRIO-FOOT® Versus Usual Prothesis Tasks Tibial Amputees

Evaluate a new porosthetic device in lower limb amputees.

PubMed Articles [2478 Associated PubMed Articles listed on BioPortfolio]

Transfemoral amputee intact limb loading and compensatory gait mechanics during down slope ambulation and the effect of prosthetic knee mechanisms.

Intact limb knee osteoarthritis is a prevalent secondary disability in transfemoral amputees. Walking down a ramp may increase this risk due to excessive limb loading. We sought to determine whether i...

Gait termination on a declined surface in trans-femoral amputees: Impact of using microprocessor-controlled limb system.

Walking down ramps is a demanding task for transfemoral-amputees and terminating gait on ramps is even more challenging because of the requirement to maintain a stable limb so that it can do the neces...

Profile of upper limb recovery and development of secondary impairments in patients after stroke with a disabled upper limb: An observational study.

To investigate, in patients after stroke with a very weak upper limb, the profile of recovery for upper limb activity over the first 12 weeks, and whether early secondary impairments predict later up...

Targeted muscle reinnervation: considerations for future implementation in adolescents and younger children.

Prosthetic options for patients with proximal upper limb absence are limited. Current above elbow prostheses may restore basic motor functions for crucial activities, but they are cumbersome to operat...

A systematic review investigating the relationship of electroencephalography and magnetoencephalography measurements with sensorimotor upper limb impairments after stroke.

Predicting sensorimotor upper limb outcome receives continued attention. Measures by electroencephalography (EEG) and magnetoencephalography (MEG) could be neurophysiological predictors for sensorimot...

Medical and Biotech [MESH] Definitions

The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.

Distinct regions of mesenchymal outgrowth at both flanks of an embryo during the SOMITE period. Limb buds, covered by ECTODERM, give rise to forelimb, hindlimb, and eventual functional limb structures. Limb bud cultures are used to study CELL DIFFERENTIATION; ORGANOGENESIS; and MORPHOGENESIS.

The region of the upper limb between the metacarpus and the FOREARM.

Injuries to the part of the upper limb of the body between the wrist and elbow.

More From BioPortfolio on "The Effect of Amputation on Spatial Visual Representation in Peripersonal Space"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...


Searches Linking to this Trial