Advertisement

Topics

Evaluating Efficacy and Safety of Transcranial TMS Stimulation (TMS) for the Preemptive Treatment of Migraine With Aura

2014-08-27 03:39:32 | BioPortfolio

Summary

Assess safety and efficacy of TMS for the treatment of migraine with aura

The hypothesis is that TMS treatments delivered to the occipital lobe of the brain (visual cortex) can stop or interrupt the spreading cortical brain activity that causes or contributes to the migraine headache. A pair of transcranial TMS treatments at <1 Tesla for ~500 microseconds output of the TMS stimulator approximately 30 seconds apart may stop the aura and prevent the subsequent headache.

Description

In the Lead-in Phase patients will use a PDA to keep an electronic diary of their migraine episodes. During a migraine episode, as well as the time in between headaches, the PDA prompts the patient to answer questions. Each evening, the patient will place the PDA into an electronic telephone cradle, and the information will be transmitted electronically from the PDA to the data management team to assess the frequency of aura with migraine episodes and patient proficiency with the PDA. During this one month period, the patient must experience at least one migraine episode to enter the Treatment Phase.

After one month, the patients will return to the clinic with their PDA and will enter the Treatment Phase to be randomized to either the TMS only group or the Sham stimulation only group. Patients will enter information into the PDA for three auras treated or three months, which ever comes first.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Conditions

Migraine With Aura

Intervention

TMS Device

Location

San Francisco Headache Clinic
San Francisco
California
United States
94109

Status

Active, not recruiting

Source

Neuralieve

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:39:32-0400

Clinical Trials [847 Associated Clinical Trials listed on BioPortfolio]

Tonabersat in the Prophylaxis of Migraine With Aura

Overall trial objectives: 1. Can treatment with tonabersat reduce the number of days with aura and/or migraine headache in patients with migraine with aura 2. How well tol...

Endothelin-1 as a Potential Trigger of Migraine Aura

One third of migraine patients experience aura, i.e. dramatic, transient neurological symptoms, most often in the form of visual disturbances, that usually appear before the onset of migra...

Interest of the T2 * Sequence in MRI for the Diagnosis of Migraine Aura in the Acute Phase.

investigators hypothesize that T2 * vein abnormalities are frequent and are specific to the migraine aura.

Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura

This is a a multi-center, randomized, double-blind, parallel group, and placebo controlled, two-arm study of a single oral dose of NXN-188 for the treatment of acute migraine headache with...

Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura

The following study is being conducted to explore the safety and effectiveness of a new chemical entity called NXN-188 in subjects with a history of migraine with aura. In this study subje...

PubMed Articles [2307 Associated PubMed Articles listed on BioPortfolio]

Ischaemic stroke may symptomatically manifest as migraine aura.

Migraine aura is a common stroke mimic. We hypothesised that some patients with typical migraine aura symptoms might have embolic stroke detected as the precipitant. We identified fourteen patients wh...

The Migraine Aura.

This article discusses the basic mechanisms of migraine aura and its clinical significance based upon evidence from human studies and animal models.

Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report.

This article reports a case of exploding head syndrome (EHS) as an aura of migraine with brainstem aura (MBA). A middle-aged man presented with intermittent episodes of a brief sensation of explosion ...

Migraine-like visual aura: Can it be an early-onset symptom of astrocytoma?

Photopsia, fortification spectra, and the slow propagation of a scintillating scotoma across the visual field are typical diagnostic features of the visual aura of migraine. In the vast majority of ca...

Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks.

To review the pathophysiologic, epidemiologic, and clinical evidence for similarities and differences between migraine with and without aura.

Medical and Biotech [MESH] Definitions

A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)

Removal of a MEDICAL DEVICE from the market due to the identification of an intrinsic property of the device that results in a serious risk to public health.

More From BioPortfolio on "Evaluating Efficacy and Safety of Transcranial TMS Stimulation (TMS) for the Preemptive Treatment of Migraine With Aura"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...


Searches Linking to this Trial