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Cognitive Impairment Following Sedation for Colonoscopy With Propofol, Midazolam and Fentanyl Combinations

2014-08-27 03:39:43 | BioPortfolio

Summary

Our hypothesis is that adding midazolam and/or fentanyl to propofol sedation for elective outpatient colonoscopy increases cognitive impairment at hospital discharge without improving intraoperative conditions or reducing intraoperative side-effects.

200 healthy patients aged 18 years or older will be randomised to receive propofol or propofol plus midazolam and/or fentanyl. Cognitive impairment will be tested at hospital discharge using Cogstate computerised testing software.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Conditions

Cognitive Impairment

Intervention

Propofol, midazolam, fentanyl

Location

Royal Melbourne Hospital
Parkville
Victoria
Australia
3050

Status

Recruiting

Source

Melbourne Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:39:43-0400

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Medical and Biotech [MESH] Definitions

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

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A condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.

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