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A Phase I/II Study of HKI-272 in Combination With Paclitaxel in Subjects With Advanced Solid Tumors and Breast Cancer

2014-08-27 03:39:44 | BioPortfolio

Summary

The purposes of this study are:

- to find the highest tolerable dose of HKI-272 in combination with Paclitaxel

- to assess the safety of the combination of the two drugs

- to obtain preliminary information on whether the combination of the two drugs has any effect on solid tumors

Description

The study will be conducted in two parts. In the first part, testing will be done to determine the highest tolerable dose of HKI-272 and Paclitaxel in patients with advanced solid tumors.

In the second part of the study, subjects with breast cancer will be enrolled to further test the safety of the drug combination, and to obtain preliminary data on the efficacy of the combination.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Breast Cancer

Intervention

HKI-272

Location

La Jolla
California
United States
92093

Status

Active, not recruiting

Source

Wyeth

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:39:44-0400

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