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Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic

2014-07-24 14:22:09 | BioPortfolio

Summary

The objective of the study was to establish which anesthetic procedure used during flexible bronchoscopy has the lowest index of complications.

Description

This prospective randomized study analyzed 80 patients that underwent flexible bronchoscopy. Patients were randomly assigned to four groups of 20 patients each according to the anesthetic combination used: 200 mg topical lidocaine (LID group); 200 mg topical lidocaine and 2 mg/kg propofol (PPF group); 200 mg topical lidocaine and 20 mcg/kg alfentanil (ALF group); or 200 mg topical lidocaine and 0.05 mg/kg midazolam (MID group). Scores were assigned to patients according to the different variables observed during the endoscopic procedure; the lower the score, the lower the complication index.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Factorial Assignment, Masking: Single Blind, Primary Purpose: Treatment

Conditions

Lung Cancer

Intervention

propofol, midazolam, alfentanil, lidocaine

Location

Hospital Pompeia
Caxias do Sul
RS
Brazil
95010-005

Status

Completed

Source

Hospital Pompeia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:22:09-0400

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Medical and Biotech [MESH] Definitions

A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.

Tumors or cancer of the LUNG.

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.

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