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Multicenter Trial of Immunologic Markers to Predict Long Term Virologic Outcomes

2014-07-24 14:22:10 | BioPortfolio

Summary

Purpose is to identify whether immune markerscan predict success of salvage anti-retroviral therapy.

Description

Over the last several years two markers of disease have been utilized to determine if antiretroviral therapy has been successful, one is a CD4 cell count (reflects the immunocompetence of an infected individual) and a HIV viral load (a blood test used to determine the amount of HIV in the infected individual). However in patients who fail their first line of therapythe likelihood of extended resuppressing viral replication with subsequent therapies may be as low as 25-50%. This information may take several months to determine the new therapies possible continuing success. It would be preferable to have additional markers that respond to therapies in the first several weeks to such therapies, therfore possibly offering patients alternate treatment earlier without potentiatinglong term side effects and possible further drug resistance.

Study Design

Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective

Conditions

HIV Infections

Location

McMaster Health Science Center
Hamilton
Ontario
Canada
L8N 3Z5

Status

Completed

Source

Ottawa Hospital Research Institute

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:22:10-0400

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