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PURPOSE: This phase II trial is studying the side effects and how well VEGF Trap works in treating patients with stage II or stage III multiple myeloma that has relapsed or not responded to previous treatment.
- Evaluate the safety and efficacy of VEGF Trap in patients with relapsed or refractory, stage II or III multiple myeloma.
- Evaluate the angiogenic properties of tissue for correlative studies in patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive VEGF Trap IV over 1 hour on day 1. Treatment repeats every 2 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Patients undergo blood collection periodically for correlative and pharmacokinetic studies. Samples are analyzed for biological markers and angiogenic profiles via immunoenzyme techniques and flow cytometry. Biomarkers may include vascular endothelial growth factor (VEGF) subtypes, platelet-derived growth factor, fibroblast growth factor, thrombopoietin, stromal-cell-derived factor, interleukin (IL)-6, IL-7, and VEGF receptor 1.
After completion of study treatment, patients are followed for 60 days and then periodically thereafter.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Treatment
Multiple Myeloma and Plasma Cell Neoplasm
aflibercept, flow cytometry, immunoenzyme technique, immunologic technique, laboratory biomarker analysis, pharmacological study
Albert Einstein Cancer Center at Albert Einstein College of Medicine
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:40:04-0400
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