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RATIONALE: Drugs used in chemotherapy, such as ABT-751, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Compare the time to disease progression in children with refractory or relapsed neuroblastoma treated with ABT-751 vs historical controls.
- Determine the objective response rate in patients with measurable disease treatment with this drug.
- Determine whether ABT-751 improves quality of life of these patients.
- Determine the toxicity of ABT-751.
- Determine the pharmacokinetic profile of ABT-751 in these patients.
OUTLINE: This is a multicenter, historical control study. Patients are stratified according to disease type (measurable lesions by CT scan or MRI vs evaluable disease [bone marrow or iodine I 123 metaiodobenzylguanidine-positive lesions]).
Patients receive oral ABT-751 once daily on days 1-7. Treatment repeats every 21 days for 52 courses in the absence of disease progression or unacceptable toxicity.
Blood is collected periodically during course 1 for pharmacokinetic studies.
Quality of life is assessed at baseline and prior to each course of treatment.
PROJECTED ACCRUAL: A total of 88 patients will be accrued for this study.
Primary Purpose: Treatment
ABT-751, pharmacological study, quality-of-life assessment
UAB Comprehensive Cancer Center
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:40:05-0400
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