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Natural Killer Index From Hematopoietic Stem Cell Graft

2014-08-27 03:40:06 | BioPortfolio

Summary

Numerous studies about the potential role of NK alloreactiv during a n hematopoietic stem cells graft are based on genotypics analyses of the KIR receptors and on genotypic incompatibilities between KIR and HLA for couple donor/recipient. There is still a lot of issues non resolved: Are KIR really expressed and how occur their expression during time when hematopoïetic reconstitution? Is it depending on HLA of the recipient?If KIR are expressed, what are the mechanisms of alloreactivity of NK cells? Are NK able to lyse tumoral cells? Could alloreactiv NK cells constitute a therapeutic tool able to induce tolerance and elimination of leukemia during hematopoïetic stem cells grafts?

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Conditions

Acute Lymphoblastic Leukemia

Intervention

Blood test

Location

CHU de Nantes
Nantes
France
44093

Status

Recruiting

Source

Nantes University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:40:06-0400

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