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Effects of Steroids, Controlling Blood Sugar Levels, and Avoidance of Deep Anesthesia on Patient Outcomes After Major Vascular Surgery

2014-07-23 21:30:12 | BioPortfolio

Summary

The perioperative period is characterized by an intense inflammatory response marked by elevated concentrations of inflammatory markers like C-reactive protein (CRP). This response has been linked to increased perioperative morbidity and mortality. Available evidence suggests that blunting the inflammatory response to surgery might improve perioperative outcomes. The benefits from blunting the surgical stress response are likely to be greatest in the high risk patient such as those having major non-cardiac surgery.

Description

We will study three interventions potentially modulating perioperative inflammation, corticosteroids, tight glucose control and light anesthesia and their effects on major morbidity and mortality resulting from major non-cardiac surgery.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Major Non-Cardiac Surgery

Intervention

intensive glucose management, deeper anesthetic management, placebo, Dexamethasone, conventional glucose control, Lighter anesthesia group

Location

Cleveland Clinic Foundation
Cleveland
Ohio
United States
44195

Status

Recruiting

Source

Aspect Medical Systems

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:30:12-0400

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Anesthesiology
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...


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