Effects of Steroids, Controlling Blood Sugar Levels, and Avoidance of Deep Anesthesia on Patient Outcomes After Major Vascular Surgery

2014-07-23 21:30:12 | BioPortfolio


The perioperative period is characterized by an intense inflammatory response marked by elevated concentrations of inflammatory markers like C-reactive protein (CRP). This response has been linked to increased perioperative morbidity and mortality. Available evidence suggests that blunting the inflammatory response to surgery might improve perioperative outcomes. The benefits from blunting the surgical stress response are likely to be greatest in the high risk patient such as those having major non-cardiac surgery.


We will study three interventions potentially modulating perioperative inflammation, corticosteroids, tight glucose control and light anesthesia and their effects on major morbidity and mortality resulting from major non-cardiac surgery.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Major Non-Cardiac Surgery


intensive glucose management, deeper anesthetic management, placebo, Dexamethasone, conventional glucose control, Lighter anesthesia group


Cleveland Clinic Foundation
United States




Aspect Medical Systems

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:30:12-0400

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