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Dose-Finding Pediatric Trial With Sugammadex (19.4.306)(P05961)(COMPLETED)

2015-06-09 01:36:51 | BioPortfolio

Published on BioPortfolio: 2015-06-09T01:36:51-0400

Clinical Trials [895 Associated Clinical Trials listed on BioPortfolio]

Comparison of 4.0 mg/kg Sugammadex at 1-2 PTC in Renal or Control Patients (19.4.328)(P05769AM1)

The current trial was designed to investigate the effects of 4.0 mg.kg-1, of sugammadex on efficacy, safety and pharmacokinetics in subjects with severe renal impairment

Use of Sugammadex Administered at 5 Minutes After Administration of 1.2 mg/kg Esmeron® (19.4.205)(P05942)(COMPLETED)

The purpose of this study is to determine the optimal dose of sugammadex when this compound is administered during deep neuromuscular block. Sugammadex is administered shortly (5 minutes) ...

Sugammadex Hypersensitivity Study (Study P06042)(COMPLETED)

This trial is being conducted to study the potential for hypersensitivity symptoms at the time of initial exposure to sugammadex and upon repeat exposure, since it is unknown whether the f...

Sugammadex ED90 Dose in the Obese Patients

The purpose of this study is to determine the minimum effective dose of sugammadex, an antagonist of neuromuscular blockade used during anesthesia practice, in obese patients, considering ...

Recovery Effect of Sugammadex Measured by Bispectral and Neurosense Indices

It has been demonstrated that antagonism of neuromuscular blockade (neostigmine 0.04 mg kg-1) affects depth of anaesthesia with an increase in bispectral index (mean maximal change of 7.1)...

PubMed Articles [2037 Associated PubMed Articles listed on BioPortfolio]

Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2 Cases.

We describe 2 patients who developed anaphylactic shock after sugammadex administration during anesthesia. Both had no history of prior sugammadex administration. The serum tryptase concentrations wer...

Comparison of postoperative coagulation profiles and outcome for sugammadex versus pyridostigmine in 992 living donors after living-donor hepatectomy.

Donor safety is the major concern in living donor liver transplantation, although hepatic resection may be associated with postoperative coagulopathy. Recently, the use of sugammadex has been graduall...

Incidence of hypersensitivity and anaphylaxis with sugammadex.

To evaluate the incidence of hypersensitivity and anaphylaxis after administration of sugammadex.

Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient: A Case Report.

We report the case of a 60-year-old man who underwent open radical prostatectomy for prostate adenocarcinoma. He had no known cardiac disease or symptoms other than controlled hypertension and remote ...

In reply: Is sugammadex alone enough to cause anaphylaxis?

Medical and Biotech [MESH] Definitions

Abnormally slow pace of regaining CONSCIOUSNESS after general anesthesia (ANESTHESIA, GENERAL) usually given during surgical procedures. This condition is characterized by persistent somnolence.

Inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. Closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.

Epidural anesthesia administered via the sacral canal.

An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.

A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.

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