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Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response to IVF Drugs

2014-08-27 03:40:53 | BioPortfolio

Summary

The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs, prior to proceeding to oocyte donation or abandoning fertility treatment.

Description

Poor responders are a diverse group of IVF patients who fail to respond to IVF drugs. In these patients pregnancy rates remain disappointingly low and usually oocyte donation is their only viable option. The need for lengthy ovarian stimulation regimes can be avoided by performing IVF during a natural menstrual cycle. However, the main problem with a natural cycle is that successful IVF outcome can be compromised by a premature LH surge. This problem can be solved by the administration of GnRH antagonists that suppress endogenous gonadotropin levels, comprising a modified natural cycle (MNC). Previous studies have shown that MNC offers no realistic chances of pregnancy prior to oocyte donation. In this study we will re-assess this view by showing that MNC offers some, albeit small, chances of positive IVF outcome in patients with known previous poor response prior to oocyte donation.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Infertility

Intervention

recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)

Location

Eugonia
Athens
Greece
11528

Status

Active, not recruiting

Source

Eugonia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:40:53-0400

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A Netherlands overseas territory in the Lesser Antilles in the West Indies. It includes the islands of Aruba, Bonaire, Curacao, Saba, St. Eustatius, and the southern part of St. Martin. Its capital is Willemstad. Its former names are Curacao, Netherlands West Indies, and Dutch West Indies. Its colonial status was abolished by the Netherlands government in 1954 but it is considered an integral part of the Dutch realm. There is no positive evidence for the name Antilles. (From Random House Unabridged Dictionary, 2d ed, 1993 & Webster's New Geographical Dictionary, 1988, p823)

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A country in Western Europe, bordering the North Sea, between France and the Netherlands. The capital is Brussels.

Island in the Caribbean Sea, north of Venezuela. In 1986 it became a separate, autonomous member of the Kingdom of the Netherlands.

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