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Efficacy and Safety of Subcutaneous Immunotherapy in Birch Pollen Allergic Patients

2014-08-27 03:41:08 | BioPortfolio

Summary

To compare versus placebo the efficacy and safety of recombinant Bet v1, natural purified Bet v1 and birch pollen licenced extract used for subcutaneous immunotherapy.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Allergy

Intervention

Subcutaneous immunotherapy - Recombinant birch pollen

Location

Pr Gabrielle PAULI
Strasbourg
France
67091

Status

Terminated

Source

Stallergenes

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:41:08-0400

Clinical Trials [680 Associated Clinical Trials listed on BioPortfolio]

Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients

A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch polle...

SUBLIVAC FIX Birch Phase III Short-term Efficacy

The aim of this phase III study is to asses if SUBLIVAC FIX Birch is safe and effective in reducing birch allergy induced symptoms and birch allergy medication usage.

Efficacy and Safety Trial of SLITone(TM) Birch in Subjects With Hayfever

The trial is performed to assess the efficacy and safety of SLIT One birch for treatment of birch pollen induced allergy

Probiotics for Birch Pollen Allergy

Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed ...

Safety and Efficacy of Specific Immunotherapy With an Aluminium Hydroxide-Adsorbed Allergoid Preparation of Birch Pollen Allergens

This study is an evaluation of the safety and efficacy of specific immunotherapy with a birch pollen allergoid.

PubMed Articles [2723 Associated PubMed Articles listed on BioPortfolio]

Birch pollen specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL-33 in mice.

The underlying mechanism of allergen specific subcutaneous immunotherapy (SCIT) is not yet fully understood, but suppression of allergen-specific Th2 cells and production of allergen-specific IgG4 ant...

New EAACI definition on pollen season mirrors symptom load for grass and birch pollen-induced allergic rhinitis.

The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergens exposure time-periods. We evaluate...

Randomised controlled trials define shape of dose-response for Pollinex Quattro Birch allergoid immunotherapy.

The Birch Allergoid, Tyrosine Adsorbate, Monophosphoryl Lipid A (POLLINEX Quattro Plus 1.0 ml Birch 100%) is an effective, well-tolerated short course subcutaneous immunotherapy. We performed two phas...

The Relationship of Pollen Dispersal with Allergy Symptoms and Immunotherapy: Allergen Immunotherapy Improves Symptoms in the Late Period of Japanese Cedar Pollen Dispersal.

The severity of symptoms of pollen-induced allergic rhinitis is affected by the amount of scattered pollen. However, the relationships between the pollen dispersal pattern, symptom severity, and treat...

Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT.

The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of lev...

Medical and Biotech [MESH] Definitions

A method of treating an ALLERGY by administering ALLERGENS, in liquid formulation or tablets, to the ORAL MUCOSA under the tongue.

A growth from a pollen grain down into the flower style which allows two sperm to pass, one to the ovum within the ovule, and the other to the central cell of the ovule to produce endosperm of SEEDS.

Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).

Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)

The uptake of substances via the SUBCUTANEOUS TISSUE.

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