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Intravitreal Ranibizumab Treatment of Central Serous Chorioretinopathy

2014-07-23 21:34:35 | BioPortfolio

Summary

The purpose of this study is to examine the effects of Lucentis for active Central Serous Chorioretinopathy.

Description

This is an open-label, Phase I study of intravitreally administered ranibizumab in subjects with unresolving CSC and subfoveal fluid. Patients will be evaluated at baseline with ophthalmic examination, fluorescein angiography, optical coherence tomography, and color photography. Subjects will receive open-label intravitreal injections of 0.5 mg ranibizumab administered every 28 days (± 2 days) for 3 injections. Thereafter they are to be evaluated every month until month 12. Treatment will be administered to patients if there is presence of active leakage as determined by fluorescein angiography or persistence presence of sub retinal fluid upon OCT examination at that monthly visit.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Central Serous Chorioretinopathy

Intervention

rhuFab V2 [ranibizumab] ( Lucentis )

Location

Vitreous Retina Macula Consultants of New York, P.C.
New York
New York
United States
10022

Status

Completed

Source

Vitreous -Retina- Macula Consultants of New York

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:34:35-0400

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PubMed Articles [4305 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A visual impairment characterized by the accumulation of fluid under the retina through a defect in the retinal pigment epithelium.

Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).

One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)

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A thin lining of closed cavities of the body, consisting of a single layer of squamous epithelial cells (MESOTHELIUM) resting on a thin layer of CONNECTIVE TISSUE, and covered with secreted clear fluid from blood and lymph vessels. Major serous membranes in the body include PERICARDIUM; PERITONEUM; and PLEURA.

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