Transplantation of Autologous RPE Versus Translocation of Autologous RPE and Choroid in AMD

2014-07-23 21:34:39 | BioPortfolio


The purpose of this study is to evaluate two surgical interventions in patients with AMD.


The Submacular surgical trials have shown that submacular membrane extraction alone did not improve or preserve visual acuity in patients with AMD. Transplantation of autologous RPE and translocation of autologous RPE and choroid represent two promising therapeutic interventions in patients with AMD. This prospective, randomized clinical trial compares the two surgical treatments and additionally compares the clinical results (visual acuity, FLA) with OCT- and UHR-OCT data.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Age-Related Macular Degeneration


Transplantation of autologous RPE, Translocation of autologous RPE and Choroid


Department of Opthalmology, Rudolf Foundation Clinic




The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:34:39-0400

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Medical and Biotech [MESH] Definitions

Transplantation from another site in or on the body of the individual receiving it.

Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

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Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

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Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...

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