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Transplantation of Autologous RPE Versus Translocation of Autologous RPE and Choroid in AMD

2014-07-23 21:34:39 | BioPortfolio

Summary

The purpose of this study is to evaluate two surgical interventions in patients with AMD.

Description

The Submacular surgical trials have shown that submacular membrane extraction alone did not improve or preserve visual acuity in patients with AMD. Transplantation of autologous RPE and translocation of autologous RPE and choroid represent two promising therapeutic interventions in patients with AMD. This prospective, randomized clinical trial compares the two surgical treatments and additionally compares the clinical results (visual acuity, FLA) with OCT- and UHR-OCT data.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Age-Related Macular Degeneration

Intervention

Transplantation of autologous RPE, Translocation of autologous RPE and Choroid

Location

Department of Opthalmology, Rudolf Foundation Clinic
Vienna
Austria
1030

Status

Completed

Source

The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:34:39-0400

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Medical and Biotech [MESH] Definitions

Transplantation from another site in or on the body of the individual receiving it.

A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.

Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

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Ophthalmology
Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...


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