A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters

2014-07-23 21:34:58 | BioPortfolio


This was a Phase III, randomized, double-blind, placebo-controlled study conducted at 37 centers in the United States. 150 subjects ≥ 16 years of age who required hemodialysis (HD) and had a dysfunctional HD catheter were enrolled in the study.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Dysfunctional Hemodialysis Catheters


placebo, tenecteplase





Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:34:58-0400

Clinical Trials [610 Associated Clinical Trials listed on BioPortfolio]

A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Access Catheters

This is a Phase III, open-label, single-arm study that will be conducted at approximately 35 centers in the United States and Canada. Approximately 210 adult and pediatric subjects with dy...

A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters

This is a Phase III, open-label study that will be conducted at approximately 60 centers in the United States and Canada. Approximately 225 subjects ≥ 16 years of age who require HD and ...

Tenecteplase Pulmonary Embolism Italian Study

To assess the efficacy and safety of Tenecteplase versus Placebo in normotensive patients with sub-massive Pulmonary Embolism and Right Ventricular Dysfunction (RVD) all receiving unfracti...

Thrombolysis Using Tenecteplase (Metalyse®) in Cardiac Arrest - The TROICA Trial

The general aim of this study is to compare the efficacy and safety of tenecteplase to standard treatment during cardiopulmonary resuscitation in patients suffering from out-of-hospital ca...

Alteplase for Blood Flow Restoration in Hemodialysis Catheters

We are investigating a new way of administering alteplase to remove clots from hemodialysis catheters. Currently, alteplase is left to dwell inside the catheter between dialysis treatment...

PubMed Articles [1580 Associated PubMed Articles listed on BioPortfolio]

Factors Affecting Patency Following Successful Percutaneous Intervention for Dysfunctional Hemodialysis Vascular Access.

This study aimed to investigate the patency following initial successful percutaneous transluminal angioplasty (PTA) for untreated dysfunctional hemodialysis vascular access and to identify predictors...

The Relationship Between Bloodstream Infections and Hemodialysis Catheters in Hospital-Based Hemodialysis Units.

As the number of patients requiring hemodialysis increases, so does the number of patients who require complex care and whose care requires a hospital hemodialysis unit setting rather than a freestand...

Treatment of Prosthetic Valve Thrombosis with Bolus Dose Tenecteplase: An Experience from a Developing Country.

Prosthetic valve thrombosis (PVT) in metallic prosthetic cardiac valves is not an uncommon condition, and has high mortality and morbidity. Although surgery is the traditional choice for PVT therapy, ...

Clinical Trial on the Effects of Vitamin D Supplementation on Metabolic Profiles in Diabetic Hemodialysis.

The current study was conducted to assess the effects of vitamin D supplementation on insulin metabolism, lipid fractions, biomarkers of inflammation, and oxidative stress in diabetic hemodialysis (HD...

Left Brachiocephalic Vein Stenosis due to the Insertion of a Temporal Right Subclavian Hemodialysis Catheter.

Central vein stenosis/occlusion is a common well-described sequel to the placement of hemodialysis catheters in the central venous system. The precise mechanisms by which central vein stenosis occurs ...

Medical and Biotech [MESH] Definitions

Hospital units in which care is provided the hemodialysis patient. This includes hemodialysis centers in hospitals.

Catheters inserted into various locations within the heart for diagnostic or therapeutic purposes.

Catheters designed to be left within an organ or passage for an extended period of time.

Catheters inserted into the URINARY BLADDER or kidney for therapeutic or diagnostic purposes.

Long-term maintenance hemodialysis in the home.

More From BioPortfolio on "A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters"

Quick Search


Relevant Topic

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Searches Linking to this Trial